Results 21 to 30 of about 12,362 (197)

Update 2016–2018 of the Nationwide Danish Fungaemia Surveillance Study: Epidemiologic Changes in a 15-Year Perspective

Journal of Fungi, 2021
As part of a national surveillance programme initiated in 2004, fungal blood isolates from 2016–2018 underwent species identification and EUCAST susceptibility testing. The epidemiology was described and compared to data from previous years. In 2016–2018,
Malene Risum, Karen Astvad, Helle Krogh Johansen, Henrik Carl Schønheyder, Flemming Rosenvinge, Jenny Dahl Knudsen, Rasmus Krøger Hare, Raluca Datcu, Bent Løwe Røder, Valeria Stanislavovna Antsupova, Lise Kristensen, Jan Berg Gertsen, Jens Kjølseth Møller, Esad Dzajic, Turid Snekloth Søndergaard, Maiken Cavling Arendrup   +15 more
doaj   +1 more source

Resistance to Echinocandins Complicates a Case of Candida albicans Bloodstream Infection: A Case Report

Journal of Fungi, 2021
Invasive candidiasis is known to be one of the most common healthcare-associated complications and is caused by several Candida species. First-line drugs, particularly echinocandins, are effective, but there are increasing reports of resistance to these ...
Laura Trovato, Dafne Bongiorno, Maddalena Calvo, Giuseppe Migliorisi, Albino Boraccino, Nicolò Musso, Salvatore Oliveri, Stefania Stefani, Guido Scalia   +8 more
doaj   +1 more source

Understanding Echinocandin Resistance in the Emerging Pathogen Candida auris. [PDF]

Antimicrob Agents Chemother, 2018
ABSTRACT Candida auris has simultaneously emerged on five continents as a fungal pathogen causing nosocomial outbreaks. The challenges in the treatment of C. auris infections are the variable antifungal susceptibility profiles among clinical isolates and the development of resistance to single ...
Kordalewska M, Lee A, Park S, Berrio I, Chowdhary A, Zhao Y, Perlin DS.   +6 more
europepmc   +4 more sources

Epidemiology of Echinocandin Resistance in Candida [PDF]

Current Fungal Infection Reports, 2014
Echinocandins are the newest antifungal agents approved for use in treating Candida infections in the US. They act by interfering with 1,3-β-D-glucan synthase and therefore disrupt cell wall production and lead to Candida cell death. There is no intrinsic resistance to echinocandins among Candida species, and isolates from historic collections archived
Nina T, Grossman, Tom M, Chiller, Shawn R, Lockhart   +2 more
openaire   +2 more sources

Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland [PDF]

Infection, 2020
AbstractEchinocandins represent the first-line therapy of candidemia. Echinocandin resistance among Candida spp. is mainly due to acquired FKS mutations. In this study, we report the emergence of FKS-mutant Candida albicans/glabrata in Switzerland and provide the microbiological and clinical characteristics of 9 candidemic episodes.
A. T. Coste, A. Kritikos, J. Li, N. Khanna, D. Goldenberger, C. Garzoni, C. Zehnder, K. Boggian, D. Neofytos, A. Riat, D. Bachmann, D. Sanglard, F. Lamoth, F. Lamoth, N. Khanna, K. Boggian, D. Sanglard   +16 more
openaire   +4 more sources

Echinocandin-resistant Candida tropicalis Bloodstream Infections [PDF]

Open Forum Infectious Diseases, 2017
BACKGROUND: The aim of this study is to describe the clinical manifestations, molecular mechanisms, and treatment outcomes of patients with echinocandin-resistant Candida tropicalis (C. tropicalis) bloodstream infections (BSI). METHODS: A PubMed search was conducted using the search terms related to C. tropicalis BSI and echinocandin resistance.
Sfeir, Maroun, Jiménez-Ortigosa, Cristina, Schuetz, Audrey, Jenkins, Stephen, Jones, Sian, Soave, Rosemary, Van Besien, Koen, Satlin, Michael, Small, Catherine, Perlin, David, Walsh, Thomas   +10 more
openaire   +1 more source

Set of Classical PCRs for Detection of Mutations in Candida glabrata FKS Genes Linked with Echinocandin Resistance [PDF]

, 2014
Clinical echinocandin resistance among Candida glabrata strains is increasing, especially in the United States. Antifungal susceptibility testing is considered mandatory to guide therapeutic decisions.
Afeltra, Javier, Dudiuk, Catiana Beatriz, Gamarra, Maria Soledad, Garcia, Guillermo Manuel, Jimenez Ortigoza, Cristina, Leonardelli, Florencia, Perlin, David S., Vitale, Roxana Gabriela   +7 more
core   +2 more sources

Breakthrough Bloodstream Infections Caused by Echinocandin-Resistant Candida tropicalis: An Emerging Threat to Immunocompromised Patients with Hematological Malignancies

Journal of Fungi, 2020
Background. Candida tropicalis is a virulent fungal pathogen for which echinocandins are the primary therapy. Emergence of resistance to echinocandins of C. tropicalis carries potentially ominous therapeutic implications. Methods.
Maroun M. Sfeir, Cristina Jiménez-Ortigosa, Maria N. Gamaletsou, Audrey N. Schuetz, Rosemary Soave, Koen Van Besien, Catherine B. Small, David S. Perlin, Thomas J. Walsh   +8 more
doaj   +1 more source

The Emergence of Echinocandin-Resistant Candida glabrata Exhibiting High MICs and Related FKS Mutations in Turkey

Journal of Fungi, 2021
The frequency of invasive fungal infections shows a rising trend as well as a high morbidity and mortality. Among the causative agents, a shift toward the non-albicans Candida species including Candida glabrata species complex is being observed in ...
Ali Korhan Sig, Meliha Cagla Sonmezer, Dolunay Gülmez, Serhat Duyan, Ömrüm Uzun, Sevtap Arikan-Akdagli   +5 more
doaj   +1 more source

Quantitative Analysis of Candida Cell Wall Components by Flow Cytometrywith Triple-Fluorescence Staining [PDF]

, 2017
This work was supported by the European Commission within the FP7 Framework Programme [Fungitect-Grant No 602125]. We also thank Thomas Sauer, Vienna Biocenter Campus (VBC), Austria, for technical support at the FACS facility of the MFPL, Karl Kuchler ...
Gow, N, Istel, F, Jenull, S, Lion, T, Nogueira, MF, Walker, L A   +5 more
core   +1 more source