Results 51 to 60 of about 12,362 (197)

Mechanisms of echinocandin antifungal drug resistance [PDF]

Annals of the New York Academy of Sciences, 2015
Fungal infections due to Candida and Aspergillus species cause extensive morbidity and mortality, especially among immunosuppressed patients, and antifungal therapy is critical to patient management. Yet only a few drug classes are available to treat invasive fungal diseases, and this problem is compounded by the emergence of antifungal resistance ...
openaire   +2 more sources

Evolutionary accumulation of FKS1 mutations from clinical echinocandin-resistant Candida auris

Emerging Microbes and Infections
Introduction: Drug resistance to echinocandins, first-line drugs used to treat Candida auris infection, is rapidly emerging. However, the accumulation of mutations in genes other than FKS1 (before an isolate develops to resistance via FKS1 mutations ...
Sufei Tian, Yusheng Wu, Hailong Li, Chen Rong, Na Wu, Yunzhuo Chu, Ning Jiang, Jingping Zhang, Hong Shang   +8 more
doaj   +1 more source

Invasive Fungal Breakthrough Infections under Targeted Echinocandin Prophylaxis in High-Risk Liver Transplant Recipients

Journal of Fungi, 2023
Invasive fungal infections (IFIs) are frequent and outcome-relevant complications in the early postoperative period after orthotopic liver transplantation (OLT).
Robert Breitkopf, Benedikt Treml, Thomas Senoner, Zoran Bukumirić, Sasa Rajsic   +4 more
doaj   +1 more source

Hsp21potentiates antifungal drug tolerance in Candida albicans [PDF]

, 2013
Peer reviewedPublisher ...
Alix Therese Coste, B Enjalbert, B Enjalbert, B Wachtler, Bernhard Hube, C Fradin, C Onyewu, C Onyewu, D Harcus, Duncan Wilson, F Abe, F Ritossa, FL Mayer, François L. Mayer, G Kappe, H Senn, HJ Lo, ID Jacobsen, J Buchner, JA Lewis, K Richter, K Zakikhany, L Whitesell, LE Cowen, LE Cowen, LE Cowen, LE Cowen, LE Cowen, M Lis, M Ramsdale, M Taipale, M Taipale, MA Pfaller, MA Pfaller, MC Cruz, MC Lorenz, MS Fu, N Booth, N Robbins, P Uppuluri, RK Swoboda, RS Shapiro, RS Shapiro, RS Shapiro, RS Shapiro, S Diezmann, S Hodgetts, S Lindquist, S Nicholls, S Thewes, SD Singh, SL LaFayette, WJ Steinbach   +52 more
core   +2 more sources

Differential Regulation of Echinocandin Targets Fks1 and Fks2 in Candida glabrata by the Post-Transcriptional Regulator Ssd1

Journal of Fungi, 2020
Invasive infections caused by the opportunistic pathogen Candida glabrata are treated with echinocandin antifungals that target β-1,3-glucan synthase, an enzyme critical for fungal cell wall biosynthesis. Echinocandin resistance develops upon mutation of
Kelley R. Healey, Padmaja Paderu, Xin Hou, Cristina Jimenez Ortigosa, Nicole Bagley, Biren Patel, Yanan Zhao, David S. Perlin   +7 more
doaj   +1 more source

First report on echinocandin resistant Polish Candida isolates

Acta Biochimica Polonica, 2019
Purpose: Candida spp. are ranked as one of the four major causative agents of fungal infections. The number of infections caused by Candida species resistant to fluconazole, which is applied as the first line drug in candidiasis treatment, increases every year. In such cases the application of echinocandin is necessary.
Martyna Mroczyńska, Anna Brillowska-Dabrowska   +1 more
openaire   +3 more sources

Azole-Resistant Aspergillus and Echinocandin-Resistant Candida: What Are the Treatment Options?

Current Fungal Infection Reports, 2020
This review summarizes current treatment options for echinocandin-resistant Candida spp. (ERC) and azole-resistant Aspergillus fumigatus (ARAF), emphasizing recent in vitro/in vivo data, clinical reports, and consensus statements.Advances in ERC and ARAF treatment are limited to specific antifungal combinations and dose optimization but remain reliant ...
Alison R. Novak, Mary E. Bradley, Tyree H. Kiser, Scott W. Mueller   +3 more
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Development of Echinocandin Resistance in Clavispora lusitaniae during Caspofungin Treatment [PDF]

Journal of Clinical Microbiology, 2011
ABSTRACT Clavispora lusitaniae is an opportunistic human pathogen responsible for 0.6 to 2% of candidemia. This species is intrinsically susceptible to echinocandins. Nevertheless, in this study, development of echinocandin resistance in C.
Desnos-Ollivier, Marie, Moquet, Olivier, Chouaki, Taieb, Guérin, Anne-Marie, Dromer, Françoise   +4 more
openaire   +3 more sources

New cell wall-affecting antifungal antibiotics [PDF]

, 2013
Capítulo 9.Fungi have emerged worldwide as increasingly frequent causes of healthcare-associated infections. Invasive fungal infections can be life-threatening.
Cortés, Juan Carlos G., Durán, Ángel, Ribas, Juan Carlos   +2 more
core   +2 more sources

The seizure of illicit assets: patterns of civil forfeiture in Canada and Ireland [PDF]

, 2013
No description ...
Gallant, M Michelle, King, Colin
core   +1 more source