Results 11 to 20 of about 5,729 (171)
Acute Effects of Intratumor DNA Electrotransfer
Pharmaceutics, 2022 Intratumor therapeutic DNA electroporation or electrotransfer is in clinical trials in the United States and is under development in many other countries.
Manya Bhandary +3 more
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Numerical optimization of gene electrotransfer into muscle tissue [PDF]
BioMedical Engineering OnLine, 2010 Background Electroporation-based gene therapy and DNA vaccination are promising medical applications that depend on transfer of pDNA into target tissues with use of electric pulses.
Miklavcic Damijan +3 more
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Applications of Plasmid Electrotransfer [PDF]
Technology in Cancer Research & Treatment, 2002 The use of electric pulses to transfect cells has recently been extended to show the utility of this procedure in vivo. Electrotransfer has been performed in vivo on several tissue types including skin, blood vessels, liver, tumor, muscle, cornea, brain and spleen. The most widely targeted tissue has been skeletal muscle.
Daniel, Scherman +2 more
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Topical gene electrotransfer to the epidermis of hairless guinea pig by non-invasive multielectrode array. [PDF]
PLoS ONE, 2013 Topical gene delivery to the epidermis has the potential to be an effective therapy for skin disorders, cutaneous cancers, vaccinations and systemic metabolic diseases. Previously, we reported on a non-invasive multielectrode array (MEA) that efficiently
Siqi Guo +4 more
doaj +1 more source
Pharmaceutics, 2022 Gene electrotransfer is one of the main non-viral methods for intracellular delivery of plasmid DNA, wherein pulsed electric fields are used to transiently permeabilize the cell membrane, allowing enhanced transmembrane transport.
Tina Vindiš +5 more
doaj +1 more source
Integrin α5β1 in pancreatic ductal adenocarcinoma: Tumour‒stroma crosstalk, hypoxia and therapeutic targeting. [PDF]
Clin Transl MedITGA5/integrin α5β1 promotes PDAC progression by integrating fibronectin‐dependent adhesion, hypoxia‐associated ECM remodelling, pancreatic stellate cell/cancer‐associated fibroblast activation, desmoplasia and tumour‒stroma crosstalk. These processes contribute to impaired drug delivery and therapeutic resistance.
Ma C, Wang Y, Li Y.
europepmc +2 more sources
Vaccines, 2020 The contactless high intensity pulsed electromagnetic field (HI-PEMF)-induced increase of cell membrane permeability is similar to conventional electroporation, with the important difference of inducing an electric field non-invasively by exposing a ...
Simona Kranjc Brezar +5 more
doaj +1 more source
Heliyon, 2022 Interleukin 12 (IL-12) is a cytokine used as a therapeutic molecule in cancer immunotherapy. Gene electrotransfer mediated delivery of IL-12 gene has reached clinical evaluation in the USA using a plasmid that in addition to IL-12 gene also carry an ...
Urska Kamensek +5 more
doaj +1 more source
Case Reports in Dermatology, 2022 We report a case of successful treatment of cutaneous metastases in HER2-positive breast cancer with calcium electroporation (CaEP), in addition to trastuzumab, over a period of 5 years.
Katrine Borres Jensen +3 more
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Noninvasive Gene Electrotransfer in Skin [PDF]
Human Gene Therapy Methods, 2019 The skin is considered as well suited for gene therapy and vaccination. DNA vaccines elicit both broad humoral and cellular immune responses when injected in the skin. Physical and chemical methods are needed to boost the expression. Gene electrotransfer (GET) is one of the most effective approaches.
Lise, Pasquet +5 more
openaire +2 more sources