Results 11 to 20 of about 5,598 (174)
Acute Effects of Intratumor DNA Electrotransfer
Pharmaceutics, 2022 Intratumor therapeutic DNA electroporation or electrotransfer is in clinical trials in the United States and is under development in many other countries.
Manya Bhandary +3 more
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Numerical optimization of gene electrotransfer into muscle tissue [PDF]
BioMedical Engineering OnLine, 2010 Background Electroporation-based gene therapy and DNA vaccination are promising medical applications that depend on transfer of pDNA into target tissues with use of electric pulses.
Miklavcic Damijan +3 more
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Applications of Plasmid Electrotransfer [PDF]
Technology in Cancer Research & Treatment, 2002 The use of electric pulses to transfect cells has recently been extended to show the utility of this procedure in vivo. Electrotransfer has been performed in vivo on several tissue types including skin, blood vessels, liver, tumor, muscle, cornea, brain and spleen. The most widely targeted tissue has been skeletal muscle.
Daniel, Scherman +2 more
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Pharmaceutics, 2022 Gene electrotransfer is one of the main non-viral methods for intracellular delivery of plasmid DNA, wherein pulsed electric fields are used to transiently permeabilize the cell membrane, allowing enhanced transmembrane transport.
Tina Vindiš +5 more
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Topical gene electrotransfer to the epidermis of hairless guinea pig by non-invasive multielectrode array. [PDF]
PLoS ONE, 2013 Topical gene delivery to the epidermis has the potential to be an effective therapy for skin disorders, cutaneous cancers, vaccinations and systemic metabolic diseases. Previously, we reported on a non-invasive multielectrode array (MEA) that efficiently
Siqi Guo +4 more
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Vaccines, 2020 The contactless high intensity pulsed electromagnetic field (HI-PEMF)-induced increase of cell membrane permeability is similar to conventional electroporation, with the important difference of inducing an electric field non-invasively by exposing a ...
Simona Kranjc Brezar +5 more
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Heliyon, 2022 Interleukin 12 (IL-12) is a cytokine used as a therapeutic molecule in cancer immunotherapy. Gene electrotransfer mediated delivery of IL-12 gene has reached clinical evaluation in the USA using a plasmid that in addition to IL-12 gene also carry an ...
Urska Kamensek +5 more
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Case Reports in Dermatology, 2022 We report a case of successful treatment of cutaneous metastases in HER2-positive breast cancer with calcium electroporation (CaEP), in addition to trastuzumab, over a period of 5 years.
Katrine Borres Jensen +3 more
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Applied Sciences, 2021 Long duration electric pulses are frequently used to facilitate DNA electrotransfer into cells and tissues, while electroporation pulses can be combined with electrophoresis to maximize the transfection efficiency.
Eivina Radzevičiūtė +6 more
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Molecules, 2020 Previous non-viral gene therapy was directed towards two animal models of dwarfism: Immunodeficient (lit/scid) and immunocompetent (lit/lit) dwarf mice.
Eliana Rosa Lima +7 more
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