Results 61 to 70 of about 3,553 (153)

Molecular cloning and functional characterisation of three fatty acyl elongases from the marine gammarid Echinogammarus marinus

, 2022
Trabajo presentado en 2nd edition of the Conference Lipids in the Ocean celebrado en Aveiro (Portugal) del 05 al 07 de julio de 2021.Long-chain (C20-24) polyunsaturated fatty acids (LC-PUFA) are essential nutrients that are mostly produced in marine ...
Hontoria, Francisco, Navarro, Juan Carlos, Evjemo, Jan O., Ribes-Navarro, Alberto, Kabeya, Naoki, Monroig, Óscar, Standal, Inger B.   +6 more
core  

Defects in very long chain fatty acid synthesis enhance alpha-synuclein toxicity in a yeast model of Parkinson's disease. [PDF]

PLoS ONE, 2011
We identified three S. cerevisiae lipid elongase null mutants (elo1Δ, elo2Δ, and elo3Δ) that enhance the toxicity of alpha-synuclein (α-syn). These elongases function in the endoplasmic reticulum (ER) to catalyze the elongation of medium chain fatty ...
Yong Joo Lee, Shaoxiao Wang, Sunny R Slone, Talene A Yacoubian, Stephan N Witt   +4 more
doaj   +1 more source

Activity estimates of elongases and desaturase over the 20-hour experimental time period.

, 2016
Activity estimates of elongases and desaturase over the 20-hour experimental time period.
Luis L. Fonseca (416505), Po-Wei Chen (416504), Eberhard O. Voit (50265), Yusuf A. Hannun (116276)   +3 more
core   +1 more source

Expression of genes and localization of enzymes involved in polyunsaturated fatty acid synthesis in rabbit testis and epididymis

Scientific Reports, 2022
The metabolism of polyunsaturated fatty acids (PUFAs) plays an important role in male reproduction. Linoleic and alpha-linolenic acids need to be provided in the diet and they are converted into long chain polyunsaturated fatty acids by steps of ...
Cesare Castellini, Simona Mattioli, Elena Moretti, Elisa Cotozzolo, Francesco Perini, Alessandro Dal Bosco, Cinzia Signorini, Daria Noto, Giuseppe Belmonte, Emiliano Lasagna, Gabriele Brecchia, Giulia Collodel   +11 more
doaj   +1 more source

Acute exercise‐induced lipolysis and increase in levels of fatty acid esters of hydroxy fatty acids in adipose tissue are impaired in obese and aged mice

Experimental Physiology, Volume 111, Issue 10, Page 4457-4497, 1 October 2026.
Abstract Improving adipose tissue (AT) metabolism through exercise might increase production of lipokines from the fatty acid esters of hydroxy fatty acids (FAHFA) family. Although exercise training can increase insulin sensitivity and levels of specific FAHFA in AT and the circulation in humans, the effects of acute exercise on FAHFA levels remain ...
Marko Mitrovic, Olga Horakova, Martin Riecan, Veronika Kleinova, Tomas Cajka, Lenka Rossmeislova, Ondrej Kuda, Martin Rossmeisl   +7 more
wiley   +1 more source

Role of fatty acid elongases in determination of de novo synthesized monounsaturated fatty acid species[S]

Journal of Lipid Research, 2010
Enhanced production of monounsaturated fatty acids (FA) derived from carbohydrate-enriched diets has been implicated in the development of obesity and insulin resistance.
Christopher D. Green, Cansel G. Ozguden-Akkoc, Yun Wang, Donald B. Jump, L. Karl Olson   +4 more
doaj   +1 more source

Metabolic Reprogramming of Cancer Stem Cells: Targeting Lipid Flux and Mitochondrial Plasticity to Overcome Therapeutic Resistance

Cancer Medicine, Volume 15, Issue 9, September 2026.
Metabolic reprogramming in cancer stem cells: lipid flux, mitochondrial plasticity, and therapeutic resistance. Lipid metabolism in CSCs: de novo lipogenesis, CD36 uptake, FAO, lipid droplets, and membrane remodeling. Mitochondrial dynamics in CSC survival: fusion, fission, mitophagy, OXPHOS switching, and ROS regulation.
Daniel Ejim Uti, Esther Ugo Alum, Josephine E. Egbung, Zuhair M. Mohammedsaleh, Manpreet Kaur, Kranti Kiran Reddy Ealla   +5 more
wiley   +1 more source

Egg Peptides From American Shad Extend Lifespan and Healthspan in Caenorhabditis elegans via Lipid Metabolism Remodeling and Antioxidant Defense

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
A novel shad egg peptide (EP) significantly extends Caenorhabditis elegans lifespan through a dual antiaging mechanism. EP systematically remodels lipid metabolism to reinforce cell membranes by promoting beneficial fatty acid biosynthesis and suppressing degradation. Simultaneously, its potent antioxidant activity alleviates oxidative damage, shifting
Jia Du, Qinghua Liu, Zhongxiao Wan, Naomi Sudo, Yanyang Xu   +4 more
wiley   +1 more source

Retinal very long-chain PUFAs: new insights from studies on ELOVL4 protein

Journal of Lipid Research, 2010
Compared with other mammalian tissues, retina is highly enriched in PUFA. Long-chain PUFA (LC-PUFA; C18-C24) are essential FAs that are enriched in the retina and are necessary for maintenance of normal retinal development and function. The retina, brain,
Martin-Paul Agbaga, Md Nawajes A. Mandal, Robert E. Anderson   +2 more
doaj   +1 more source

Dietary Intervention With Lutein, Docosahexaenoic Acid, and Choline During Early Development Improves Recognition Memory in Young Adult Females in an Experimental Model

Molecular Nutrition &Food Research, Volume 70, Issue 17, 15 September 2026.
Our study investigates the effects of perinatal supplementation with lutein, DHA, and choline in a controlled rat model. The results show: (1) strictly sex‐specific effects exclusively observed in female rats, (2) lutein‐dependent and synergistic effects, (3) enhancement of long‐term recognition memory, and (4) no effects on locomotor activity, anxiety‐
Leon Saschin, Gregor Fink, Maria Wohlfarth, Jonas Hauser, Jian Yan, Dirk Wiedermann, Mathias Hoehn, Jochen Wilhelm, Lea Quell, Elisabeth Sous, Jenny Voggel, Jörg Dötsch, Eva Nüsken, Kai‐Dietrich Nüsken   +13 more
wiley   +1 more source