Results 171 to 180 of about 3,272,143 (363)

Enantioconvergent Cobalt‐Catalyzed Hydroalkylation for the Construction of Fluoro, Chloro, and Trifluoromethyl Stereogenic Centers

Angewandte Chemie, EarlyView.
Cobalt‐hydride catalyzed enantioconvergent hydroalkylation with allenes and alkenes is achieved with high chemo‐, regio‐, and enantioselectivity. This method allows the streamlined synthesis of enantiomerically enriched C(sp3)–fluorine, –chlorine, and –trifluoromethyl stereocenters.
Uttam Dhawa, Xile Hu
wiley   +2 more sources

Total synthesis of 4-((3S,5R)-3,5- dihydroxynonadecyl)phenol

Results in Chemistry
This communication describes a short and effective synthetic route for the enantioselective synthesis of 4-((3S,5R)-3,5-dihydroxynonadecyl)phenol. Key steps in this synthesis include the Wittig reaction, Barbier allylation, and Sharpless dihydroxylation.
Krishnaiah Kumari, Subhashini Muvvala, Abdulrhman Alsayari, Annapurna Nowduri, Nalla Somaiah, Abhishek Shankar Saxena   +5 more
doaj  

Asymmetric Synthesis and Applications of Chiral Organoselenium Compounds: A Review

Molecules
The synthesis and application of organoselenium compounds have developed rapidly, and chiral organoselenium compounds have become an important intermediate in the field of medicine, materials, organic synthesis. The strategy of developing a green economy
Yanyu Jian, Thishana Singh, Pher G. Andersson, Taigang Zhou   +3 more
doaj   +1 more source

Rapid Assembly of the Salvileucalin B Norcaradiene Core [PDF]

, 2010
Preparation of the polycyclic core of the cytotoxic natural product salvileucalin B is described. The key feature of this synthetic strategy is a copper-catalyzed intramolecular arene cyclopropanation to provide the central norcaradiene.
Levin, Sergiy, Nani, Roger R., Reisman, Sarah E.   +2 more
core   +1 more source

Advancing Sulfinyl Radical Chemistry: An Asymmetric Smiles Rearrangement with Chiral Sulfoxides

Angewandte Chemie, EarlyView.
A visible‐light‐driven, asymmetric sulfinyl‐Smiles rearrangement enables the enantioselective trifunctionalization of chiral sulfoxides via radical addition, 1,5‐aryl migration, and sulfinyl radical interception. By tuning the redox potentials of key components, this cascade forms two C─C and one C─S bond in a single step, yielding enantioenriched ...
Yawen Hu, Till Schreyer, Cristina Nevado
wiley   +2 more sources

Enantioselective Total Synthesis of (+)-Salvileucalin B [PDF]

, 2011
An enantioselective total synthesis of the diterpenoid natural product (+)-salvileucalin B is reported. Key findings include a copper-catalyzed arene cyclopropanation reaction to provide the unusual norcaradiene core and a reversible retro ...
Levin, Sergiy, Nani, Roger R., Reisman, Sarah E.   +2 more
core   +1 more source

Nickel‐Catalyzed Suzuki–Miyaura Cross‐Coupling Reaction of Aliphatic Alcohol Derivatives

Angewandte Chemie, EarlyView.
A nickel‐catalyzed Suzuki–Miyaura coupling reaction of aliphatic mesylates is reported. This reaction provides a strategy for late‐stage functionalization of bioactive compounds that have high F(sp3). Preliminary mechanistic experiments confirm a stereoablative reaction outcome, consistent with alkyl radical intermediates.
Chloe D. Wong, Lauren C. Bradford, Nadia Hirbawi, Elizabeth R. Jarvo   +3 more
wiley   +2 more sources

Multiple Atropo Selectivity by κ2‐N,O‐Oxazoline Urea Ligands in Cobaltaelectro‐Catalyzed C─H Activations: Decoding Selectivity with Data Science Integration

ChemistryEurope
Enantioselective catalysis is one of the most prominent strategies in organic synthesis to access chiral bioactive compounds and advanced organic materials.
Philipp Boos, Neeraj Kumar Pandit, Suman Dana, Tristan von Münchow, Airu Hashidoko, Laura Haberstock, Regine Herbst‐Irmer, Dietmar Stalke, Lutz Ackermann   +8 more
doaj   +1 more source

Electrochemical Enantioselective Oxidation of Indoles via Chiral Phosphoric Acid Catalysis in Cooperation with H3PO4 in Aqueous Media

Angewandte Chemie, EarlyView.
A binary organic–inorganic acid cooperative catalytic system has been developed to achieve highly enantioselective electrochemical oxidative rearrangement of indoles. The use of electricity as an oxidant in this case showed several advantages including environmental benignity and improved enantiocontrol.
Xuefeng Tan, Zhijie Zhou, Minhua Shao, Jianwei Sun   +3 more
wiley   +2 more sources

Asymmetric synthesis of chiral heterobenzylic amines via visible-light-induced enantioselective C(sp3)-H alkylation

Green Synthesis and Catalysis
The chiral heterobenzylic amines, such as α-alkyl substituted chiral oxadiazole methylamine skeletons are widely present in pesticides and pharmaceuticals, due to their unique biological activities.
Yumei Huo, Beibei Chen, Xiaoyu Ren, Chao Wang, Rupeng Qi, Zhaoqing Xu   +5 more
doaj