Results 91 to 100 of about 16,681 (209)
Neurological and Neuropsychological Endophenotypes in Schizophrenia Spectrum Disorders
, 2011 Increasing efforts to identify alternate expressions of mental disorders that are broader than the DSM or ICD diagnostic criteria needed to diagnose them reflects a growing consensus that multidimensional expressions of psychiatric disorders may advance ...
Xiaolu Hsi +2 more
core
, 2006 Genetic variation in specific G-protein coupled receptors (GPCRs) is associated with a spectrum of respiratory disease predispositions and drug response phenotypes.
G. E. Rovati +8 more
core +1 more source
Discovering schizophrenia endophenotypes in randomly ascertained pedigrees. [PDF]
, 2015 peer reviewedBACKGROUND: Although case-control approaches are beginning to disentangle schizophrenia's complex polygenic burden, other methods will likely be necessary to fully identify and characterize risk genes.
Sprooten, Emma +22 more
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Endophenotypes in Autism Spectrum Disorders
, 2014 Autism Spectrum Disorder (ASD) is a complex disease with onset during early childhood and typically a life-long course. Genetic liability plays a prominent role in ASD, as siblings of affected individuals display on average 25-fold higher autism risk ...
Sacco, Roberto +3 more
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, 2008 The crucial role of neurological indicators in schizophrenia has been recognized as among the "target features" that encompass the idea that genetic and non-genetic processes lead to neurointegrative defects later manifested in neurocognitive systems. In
Chan, Raymond C. K. +2 more
core
Rhythm/Sleep Endophenotypes in Human CNS Disease and in Mouse Models.
, 2013 Rhythm/Sleep Endophenotypes in Human CNS Disease and in Mouse Models.
Patrick M. Nolan (319298) +1 more
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Endophenotypes, Epigenetics, Polygenicity and More: Irv Gottesman's Dynamic Legacy. [PDF]
, 2017 First, we describe the hallmark contributions of Irv Gottesman's pioneering scholarship for schizophrenia research including concepts of polygenicity, gene × environment interactions, epigenetics and the endophenotype concept.
Tamminga, Carol A, Braff, David L
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Phenotyping psychosis: Room for neurocomputational and content-dependent cognitive endophenotypes?
, 2009 Introduction. The endophenotype research strategy aims at reducing complex clinical phenomena to reveal a more tractable mapping to underlying genes. Cognitive dysfunctions have been widely pursued as target endophenotype in schizophrenia.
Lam, MML +13 more
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ENDOPHENOTYPE AND PSYCHIATRY: AN INTERESTING COMBINATION
Psychiatria Danubina, 2021 The endophenotype is a measurable component which is characterized as an intermediate part of the path existing between the genotype and phenotype of a disease. In the context of psychiatric pathologies, an endophenotype is such if it shares inheritable variations with it, if it is evident both during the active and inactive phases of the pathology, if
Juli, Giada, Juli, Rebecca, Juli, Luigi
openaire +3 more sources
SAPAP3, SPRED2, and obsessive-compulsive disorder: the search for fundamental phenotypes
Frontiers in Molecular Neuroscience, 2023 Ravi Philip Rajkumar
doaj +1 more source