Results 81 to 90 of about 16,681 (209)

Discovering imaging endophenotypes for major depression

, 2011
Psychiatry research lacks an in-depth understanding of mood disorders phenotypes, leading to limited success of genetics studies of major depressive disorder (MDD). The dramatic progress in safe and affordable magnetic resonance-based imaging methods has
G Northoff, Hasler, G, G Hasler, Northoff, G, Hasler, Gregor, Northoff G, Hasler G   +6 more
core   +1 more source

Associations between psychosis endophenotypes across brain functional, structural, and cognitive domains

, 2018
BACKGROUND: A range of endophenotypes characterise psychosis, however there has been limited work understanding if and how they are inter-related. METHODS: This multi-centre study includes 8754 participants: 2212 people with a psychotic disorder, 1487 ...
Bramon, E, Murray, RM, Jones, R, Toulopoulou, T, Kahn, R, Zartaloudi, E, McIntosh, AM, Jablensky, A, Powell, J, GROUP, Díez-Revuelta, Á, Van Os, J, Picchioni, M, McDonald, C, Ranlund, S, Thygesen, JH, Calafato, S, Crespo-Facorro, B, Hall, M-H, Iyegbe, C, Kalaydjieva, L, Daniel, C, Blakey, R, Cahn, W, Lin, K, Rujescu, D, Colizzi, M, Walshe, M, Schulze, K, Di Forti, M, Shaikh, M, Van Haren, N, Kravariti, E, Presman, A   +33 more
core   +1 more source

Genetic assessment of additional endophenotypes from the Consortium on the Genetics of Schizophrenia Family Study [PDF]

, 2016
The Consortium on the Genetics of Schizophrenia Family Study (COGS-1) has previously reported our efforts to characterize the genetic architecture of 12 primary endophenotypes for schizophrenia.
Siever, Larry J, Braff, David L, Lazzeroni, Laura C, Freedman, Robert, Light, Gregory A, Gur, Raquel E, Nuechterlein, Keith H, Tsuang, Ming T, Seidman, Larry J, Radant, Allen D, Green, Michael F, Gur, Ruben C, Greenwood, Tiffany A, Olincy, Ann, Swerdlow, Neal R, Calkins, Monica E, Tsuang, Debby W, Silverman, Jeremy M, Turetsky, Bruce I, Sugar, Catherine A, Stone, William S   +20 more
core   +1 more source

Exploring the role of hub and network dysfunction in brain connectomes of schizophrenia using functional magnetic resonance imaging

Frontiers in Psychiatry
IntroductionPathophysiological etiology of schizophrenia remains unclear due to the heterogeneous nature of its biological and clinical manifestations. Dysfunctional communication among large-scale brain networks and hub nodes have been reported. In this
Yee-Lam E. Chan, Yee-Lam E. Chan, Shih-Jen Tsai, Shih-Jen Tsai, Yijuang Chern, Yijuang Chern, Albert C. Yang, Albert C. Yang   +7 more
doaj   +1 more source

Arguments for the sake of endophenotypes: Examining common misconceptions about the use of endophenotypes in psychiatric genetics

, 2014
Endophenotypes are measurable biomarkers that are correlated with an illness, at least in part, because of shared underlying genetic influences. Endophenotypes may improve our power to detect genes influencing risk of illness by being genetically simpler,
Sprooten, Emma, Glahn, David C., McKay, David Reese, Emma E.M. Knowles, Emma Sprooten, Henriette Raventós, Raventós Vorst, Henriette, Laura Almasy, Knowles, Emma E. M., Gottesman, Irving I., Almasy, Laura, David C. Glahn, John Blangero, Blangero, John, Irving I Gottesman, D. Reese McKay   +15 more
core   +1 more source

Neurocognitive endophenotypes of obsessive-compulsive disorder [PDF]

, 2007
Endophenotypes (intermediate phenotypes) are objective, heritable, quantitative traits hypothesized to represent genetic risk for polygenic disorders at more biologically tractable levels than distal behavioural and clinical phenotypes.
Robbins, Trevor W., Barbara J. Sahakian, Naomi Fineberg, Chi-Hua Chen, Fineberg, Naomi, Samuel R. Chamberlain, Del Campo, Natalia, Chen, Chi Hua, Ed Bullmore, Trevor W. Robbins, Bullmore, Ed, Sophie Achard, Lara Menzies, Sahakian, Barbara J., Natalia del Campo, Achard, Sophie, Chamberlain, Samuel R., Menzies, Lara   +17 more
core   +1 more source

Executive functions as a potential neurocognitive endophenotype in anxiety disorders: A systematic review considering DSM-IV and DSM-5 diagnostic criteria classification

Dementia & Neuropsychologia
Evidence in the literature indicates that neurocognitive impairments may represent endophenotypes in psychiatric disorders. Objective: This study aimed to conduct a systematic review on executive functions as a potential neurocognitive endophenotype in ...
Juliana de Lima Muller, Kamilla Irigaray Torquato, Gisele Gus Manfro, Clarissa Marceli Trentini   +3 more
doaj   +1 more source

Mouse behavioral endophenotypes for schizophrenia

Brain Research Bulletin, 2010
An endophenotype is a heritable trait that is generally considered to be more highly, associated with a gene-based neurological deficit than a disease phenotype itself. Such, endophenotypic deficits may therefore be observed in the non-affected relatives of disease patients.
Laura C, Amann, Michael J, Gandal, Tobias B, Halene, Richard S, Ehrlichman, Samantha L, White, Hilary S, McCarren, Steven J, Siegel   +6 more
openaire   +2 more sources

Endophenotypes of Primary Osteoarthritis of the Hip Joint in the Bulgarian Population over 60 Years Old

Life
Aim. To identify subgroups of patients with primary osteoarthritis of the hip joint (pHOA) with similar imaging and laboratory findings, disease evolution, and response to conventional therapies. Methods.
Lyubomir Sapundzhiev, Tanya Sapundzhieva, Kamen Klinkanov, Martin Mitev, Kiril Simitchiev, Anastas Batalov   +5 more
doaj   +1 more source

All that glisters is not an endophenotype: rethinking endophenotypes in anorexia nervosa [PDF]

European Child & Adolescent Psychiatry, 2016
Micali, N, Dahlgren, CL
openaire   +4 more sources