Results 71 to 80 of about 187,332 (400)

Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding

eLife, 2017
The ESCRT machinery mediates reverse membrane scission. By quantitative fluorescence lattice light-sheet microscopy, we have shown that ESCRT-III subunits polymerize rapidly on yeast endosomes, together with the recruitment of at least two Vps4 hexamers.
Manuel Alonso Y Adell, Simona M Migliano, Srigokul Upadhyayula, Yury S Bykov, Simon Sprenger, Mehrshad Pakdel, Georg F Vogel, Gloria Jih, Wesley Skillern, Reza Behrouzi, Markus Babst, Oliver Schmidt, Michael W Hess, John AG Briggs, Tomas Kirchhausen, David Teis   +15 more
doaj   +1 more source

A Role of Phosphatidylserine in the Function of Recycling Endosomes

Frontiers in Cell and Developmental Biology, 2021
Cells internalize proteins and lipids in the plasma membrane (PM) and solutes in the extracellular space by endocytosis. The removal of PM by endocytosis is constantly balanced by the replenishment of proteins and lipids to PM through recycling pathway ...
Junya Hasegawa, Yasunori Uchida, Kojiro Mukai, Shoken Lee, Tatsuyuki Matsudaira, Tomohiko Taguchi   +5 more
doaj   +1 more source

Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB

Nature Communications, 2016
Axonal retrograde transport of signalling endosomes from the nerve terminal to the soma underpins survival. As each signalling endosome carries a quantal amount of activated receptors, we hypothesized that it is the frequency of endosomes reaching the ...
Tong Wang, Sally Martin, Tam H. Nguyen, Callista B. Harper, Rachel S. Gormal, Ramón Martínez-Mármol, S. Karunanithi, E. Coulson, N. Glass, J. Cooper-White, B. van Swinderen, F. Meunier   +11 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Toxoplasma gondii Syntaxin 6 is required for vesicular transport between endosomal-like compartments and the Golgi Complex [PDF]

, 2013
Apicomplexans are obligate intracellular parasites that invade the host cell in an active process that relies on unique secretory organelles (micronemes, rhoptries and dense granules) localized at the apical tip of these highly polarized eukaryotes ...
Clucas, Caroline, Ferguson, David J., Jackson, Allison J., Mamczur, Nicola J., Meissner, Markus   +4 more
core   +1 more source

Axonal autophagosomes recruit dynein for retrograde transport through fusion with late endosomes

Journal of Cell Biology, 2015
Late endosome-loaded dynein–snapin complexes drive amphisome retrograde transport upon fusion of autophagosomes with late endosomes in distal axons.
Xiu-Tang Cheng, Bing Zhou, Mei-Yao Lin, Qian Cai, Zu-Hang Sheng   +4 more
semanticscholar   +1 more source

Fission of Tubular Endosomes Triggers Endosomal Acidification and Movement

PLoS ONE, 2011
The early endosome acts as a sorting station for internalized molecules destined for recycling or degradation. While recycled molecules are sorted and delivered to tubular endosomes, residual compartments containing molecules to be degraded undergo "maturation" before final degradation in the lysosome.
Kumi Mesaki, Kenji Tanabe, Masanori Obayashi, Natsuko Oe, Kohji Takei   +4 more
openaire   +4 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

TMEM9B Regulates Endosomal ClC-3 and ClC-4 Transporters

Life
The nine-member CLC gene family of Cl− chloride-transporting membrane proteins is divided into plasma membrane-localized Cl− channels and endo-/lysosomal Cl−/H+ antiporters. Accessory proteins have been identified for ClC-K and ClC-2 channels and for the
Margherita Festa, Maria Antonietta Coppola, Elena Angeli, Abraham Tettey-Matey, Alice Giusto, Irene Mazza, Elena Gatta, Raffaella Barbieri, Alessandra Picollo, Paola Gavazzo, Michael Pusch, Cristiana Picco, Francesca Sbrana   +12 more
doaj   +1 more source

Novel exc Genes Involved in Formation of the Tubular Excretory Canals of Caenorhabditis elegans

G3: Genes, Genomes, Genetics, 2019
Regulation of luminal diameter is critical to the function of small single-celled tubes, of which the seamless tubular excretory canals of Caenorhabditis elegans provide a tractable genetic model.
Hikmat Al-Hashimi, Travis Chiarelli, Erik A. Lundquist, Matthew Buechner   +3 more
doaj   +1 more source