Results 91 to 100 of about 127,657 (311)

List of poised enhancers.

, 2021
Coordinates of the identified poised enhancers (genome assembly mm10). (XLSX)
Alexandra Santanach (11379032), Enrique Blanco (27905), Luciano Di Croce (190103), Mar González-Ramírez (11379023), Francesca Mugianesi (11379026), Malte Beringer (11379029), Cecilia Ballaré (568050)   +6 more
core   +1 more source

A Systematic Survey and Characterization of Enhancers that Regulate Sox3 in Neuro-Sensory Development in Comparison with Sox2 Enhancers

Biology, 2012
Development of neural and sensory primordia at the early stages of embryogenesis depends on the activity of two B1 Sox transcription factors, Sox2 and Sox3.
Hisato Kondoh, Tatsuya Takemoto, Yoshiko Ishida, Yoshifumi Kamimura, Naoko Nishimura, Masanori Uchikawa   +5 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Changes in Cis-regulatory Elements during Morphological Evolution

Biology, 2012
How have animals evolved new body designs (morphological evolution)? This requires explanations both for simple morphological changes, such as differences in pigmentation and hair patterns between different Drosophila populations and species, and also ...
Yu-Lee Paul, Stephen J. Gaunt
doaj   +1 more source

AttnW2V-Enhancer: Leveraging attention and Word2Vec for enhanced enhancer prediction

Computational and Structural Biotechnology Journal
Accurate identification of enhancer regions in DNA sequences is essential for understanding gene regulation and its role in diverse biological processes. Enhancers are regulatory elements that influence gene expression, but their detection remains challenging due to the complexity and variability of genomic sequences.
Rehman, Mobeen Ur, Abbas, Zeeshan, Ullah, Farman, Hussain, Irfan   +3 more
openaire   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

CHD-associated enhancers shape human cardiomyocyte lineage commitment

, 2023
Enhancers orchestrate gene expression programs that drive multicellular development and lineage commitment. Thus, genetic variants at enhancers are thought to contribute to developmental diseases by altering cell fate commitment.
Anjana Sundarrajan, Sushama Sivakumar, Shiqi Xie, Nikhil V Munshi, Gary C Hon, Sean C Goetsch, Daniel A Armendariz, Yihan Wang   +7 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Stable enhancers are active in development, and fragile enhancers are associated with evolutionary adaptation.

, 2019
BackgroundDespite continual progress in the identification and characterization of trait- and disease-associated variants that disrupt transcription factor (TF)-DNA binding, little is known about the distribution of TF binding deactivating mutations ...
Ovcharenko, Ivan, Li, Shan, Pennacchio, Len A, Visel, Axel, Kvon, Evgeny Z   +4 more
core   +1 more source

Discovery of MAGL Inhibition by Lophine Derivatives: An Unexpected Finding from Chemiluminescent Assay Development

Molecules
The inhibitory effects of two novel lophine derivatives were unexpectedly discovered during the development of a chemiluminescent monoacylglycerol lipase (MAGL) assay.
Roberta Ottria, Silvana Casati, Ornella Xynomilakis, Aleksandar Veselinović, Pierangela Ciuffreda   +4 more
doaj   +1 more source