Results 81 to 90 of about 141,342 (308)

Epigenetic Targeting of Aberrant Transcriptional Modulation in Pancreatic Cancer

Epigenomes, 2018
While the mortality rates of cancer are generally declining, pancreatic cancer persists to be an exception with a 5-year-survival rate of less than 7%. Late diagnosis and resistance to conventional therapies contribute to high mortality rates in spite of
Feda H. Hamdan, Steven A. Johnsen
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Predicted and validated enhancers.

, 2016
Predicted and validated enhancers.
Phillip Tate (245453), Xiao-Jiang Quan (245446), Marina Naval Sanchez (245450), Annelies Claeys (245448), Bassem A. Hassan (81220), Stein Aerts (9837), Jiekun Yan (245455)   +6 more
core   +1 more source

Tissue-specific enhancers.

, 2020
Three horizontal bars separately show the percentage of low-LoF-tolerance, all enhancers and LoF-tolerant enhancers in each tissue type. The matching vertical bar plots show the odds ratios for enrichment of the percentage of low-LoF-tolerance and LoF ...
Ekta Khurana (386863), Omer Gokcumen (401605), Duo Xu (655331)   +2 more
core   +1 more source

Topical Ocular Drug Delivery: The Impact of Permeation Enhancers

Pharmaceutics
Topical ophthalmic drug delivery targeting the posterior segment of the eye has become a key area of interest due to its non-invasive nature, safety, ease of application, patient compliance, and cost-effectiveness.
Gonçalo Santos, Esmeralda Delgado, Beatriz Silva, Berta São Braz, Lídia Gonçalves   +4 more
doaj   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells

eLife, 2016
Affinity and dose of T cell receptor (TCR) interaction with antigens govern the magnitude of CD4+ T cell responses, but questions remain regarding the quantitative translation of TCR engagement into downstream signals.
Karmel A Allison, Eniko Sajti, Jana G Collier, David Gosselin, Ty Dale Troutman, Erica L Stone, Stephen M Hedrick, Christopher K Glass   +7 more
doaj   +1 more source

AttnW2V-Enhancer: Leveraging attention and Word2Vec for enhanced enhancer prediction

Computational and Structural Biotechnology Journal
Accurate identification of enhancer regions in DNA sequences is essential for understanding gene regulation and its role in diverse biological processes. Enhancers are regulatory elements that influence gene expression, but their detection remains challenging due to the complexity and variability of genomic sequences.
Rehman, Mobeen Ur, Abbas, Zeeshan, Ullah, Farman, Hussain, Irfan   +3 more
openaire   +3 more sources

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

DENdb: database of integrated human enhancers [PDF]

, 2015
Enhancers are cis-acting DNA regulatory regions that play a key role in distal control of transcriptional activities. Identification of enhancers, coupled with a comprehensive functional analysis of their properties, could improve our understanding of ...
Kleftogiannis, Dimitrios A., Ashoor, Haitham, Bajic, Vladimir B., Radovanovic, Aleksandar   +3 more
core   +1 more source