Results 61 to 70 of about 141,342 (308)

Shadow enhancers can suppress input transcription factor noise through distinct regulatory logic

eLife, 2020
Shadow enhancers, groups of seemingly redundant enhancers, are found in a wide range of organisms and are critical for robust developmental patterning. However, their mechanism of action is unknown.
Rachel Waymack, Alvaro Fletcher, German Enciso, Zeba Wunderlich   +3 more
doaj   +1 more source

The role of noncoding genetic variants in cardiomyopathy

Frontiers in Cardiovascular Medicine, 2023
Cardiomyopathies remain one of the leading causes of morbidity and mortality worldwide. Environmental risk factors and genetic predisposition account for most cardiomyopathy cases.
Myo Htet, Shunyao Lei, Sheetal Bajpayi, Asimina Zoitou, Myrsini Chamakioti, Emmanouil Tampakakis, Emmanouil Tampakakis, Emmanouil Tampakakis   +7 more
doaj   +1 more source

Evidence‐Informed Multidisciplinary Consensus Guidance for the Psychosocial Care of Adolescents With High‐Risk Cancer: Recommendations From the Italian Association of Pediatric Hematology and Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adolescents with high‐risk cancer face complex developmental, psychosocial, and ethical challenges that extend beyond disease‐directed treatment. Although international recommendations exist for communication, psychosocial care, pediatric palliative care, survivorship, and shared decision‐making, these have largely evolved within ...
Johanna M. C. Blom, Dorella Scarponi, Giulia Zucchetti, Teresa Perillo, Maria Montanaro, Elisa Marconi, Chiara Rutigliano, Paolo Colavero, Paola Quarello, Marina Bertolotti, Monica Cellini, Carlo Clerici, Maurizio Mascarin, Francesca Bomben, Andrea Ferrari, the expert workgroup   +15 more
wiley   +1 more source

Conserved enhancers control notochord expression of vertebrate Brachyury [PDF]

, 2023
The cell type-specific expression of key transcription factors is central to development and disease. Brachyury/T/TBXT is a major transcription factor for gastrulation, tailbud patterning, and notochord formation; however, how its expression is ...
Licia Selleri, Czarkwiani, A., Aguayo, V., Visel, A., Kozmik, Z., Bötschi, S., Anna Czarkwiani, Moran, H., Bötschi, Seraina, Smolikova, J., Braasch, I., Lim, F., Fabian Lim, Osterwalder, M., Rapp, Vincent, Mosimann, Christian, Rapp, V., Emma Farley, Fitch, Olivia E, Farley, Emma, Burger, Alexa, Kemmler, Cassie, Kemmler, C., Brandon J. Mannion, Marco Osterwalder, Mosimann, C., Seraina Bötschi, Selleri, L., Visel, Axel, Jana Smolikova, Hannah R. Moran, Selleri, Licia, Burger, A., Moran, Hannah R, Farley, E., Vincent Rapp, Olivia E. Fitch, Dunja Knapp, Christian Mosimann, Knapp, Dunja, Czarkwiani, Anna, Braasch, Ingo, Viviana Hermosilla Aguayo, Kemmler, Cassie L, Ingo Braasch, Lim, Fabian, Kozmik, Zbynek, Osterwalder, Marco, Fitch, O., Hermosilla Aguayo, Viviana, Alexa Burger, Cassie L. Kemmler, Yun, M., Moran, Hannah, Mannion, Brandon J, Mannion, B., Mannion, Brandon, Zbynek Kozmik, Maximina Yun, Knapp, D., Axel Visel, Smolikova, Jana, Yun, Maximina, Fitch, Olivia   +63 more
core   +2 more sources

Single Cell Transcriptomic and Chromatin Profiles Suggest Layer Vb Is the Only Layer With Shared Excitatory Cell Types in the Medial and Lateral Entorhinal Cortex

Frontiers in Neural Circuits, 2022
All brain functionality arises from the activity in neural circuits in different anatomical regions. These regions contain different circuits comprising unique cell types.
Stefan Blankvoort, Lene Christin Olsen, Lene Christin Olsen, Lene Christin Olsen, Clifford G. Kentros   +4 more
doaj   +1 more source

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source

Chromosome X-wide Analysis of Positive Selection in Human Populations: Common and Private Signals of Selection and its Impact on Inactivated Genes and Enhancers

Frontiers in Genetics, 2021
The ability of detecting adaptive (positive) selection in the genome has opened the possibility of understanding the genetic basis of population-specific adaptations genome-wide.
Pablo Villegas-Mirón, Sandra Acosta, Jessica Nye, Jaume Bertranpetit, Hafid Laayouni, Hafid Laayouni   +5 more
doaj   +1 more source

Human Enhancement [PDF]

, 2011
Der Mensch strebt seit Urzeiten danach, seine Möglichkeiten zu erweitern und seine Leistungsfähigkeit zu steigern. Mittel dazu reichen von den ersten Werkzeugen bis zur Computertechnik, von der Erfindung des Buchdrucks bis zum drahtlosen Internet. Zunehmend beobachtbar ist die Tendenz, dass gesunde Personen Wirkstoffe zu sich nehmen in der Hoffnung auf
Eckhardt, Anne, Bachmann, Andreas, Marti, Michèle, Rütsche, Bernhard, Telser, Harry   +4 more
openaire   +4 more sources

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Quantitative Structure-Activity Relationship of Enhancers of Licochalcone A and Glabridin Release and Permeation Enhancement from Carbomer Hydrogel

Pharmaceutics, 2022
This study aimed to systematically compare licochalcone A (LicA) and glabridin (Gla) (whitening agents) release and permeation from Carbomer 940 (CP) hydrogels with different enhancers, and evaluate the relationship between the quantitative enhancement ...
Zhuxian Wang, Yaqi Xue, Zhaoming Zhu, Yi Hu, Quanfu Zeng, Yufan Wu, Yuan Wang, Chunyan Shen, Cuiping Jiang, Li Liu, Hongxia Zhu, Qiang Liu   +11 more
doaj   +1 more source