Results 61 to 70 of about 127,657 (311)
Validation using PacBio SVs and disease enhancers.
, 2020 a) Cumulative distribution function for LoF-tolerant scores for disease enhancers (red), all tested enhancers (grey), PacBio deleted enhancers (blue). KS-test P-values are between disease enhancers vs. all tested and PacBio enhancers vs. all tested.
Ekta Khurana (386863) +2 more
core +1 more source
Frontiers in Genetics, 2021 The ability of detecting adaptive (positive) selection in the genome has opened the possibility of understanding the genetic basis of population-specific adaptations genome-wide.
Pablo Villegas-Mirón +5 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook +6 more
wiley +1 more source
Transcriptionally active enhancers in human cancer cells
Molecular Systems Biology, 2021 The growth of human cancer cells is driven by aberrant enhancer and gene transcription activity. Here, we use transient transcriptome sequencing (TT‐seq) to map thousands of transcriptionally active putative enhancers in fourteen human cancer cell lines ...
Katja Lidschreiber +6 more
doaj +1 more source
Pharmaceutics, 2022 This study aimed to systematically compare licochalcone A (LicA) and glabridin (Gla) (whitening agents) release and permeation from Carbomer 940 (CP) hydrogels with different enhancers, and evaluate the relationship between the quantitative enhancement ...
Zhuxian Wang +11 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási +14 more
wiley +1 more source
The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli +3 more
wiley +1 more source
ERα super-enhancers but not conventional H3K27ac super-enhancers control E2 target genes.
, 2020 (A) Relative ERα tag counts on ERα clusters and LDECs. (B)Venn diagram showing overlap of 79, H3K27ac super-enhancers with ERα super-enhancers. (C-E) ERα binding strength (C), H3K27ac enrichment (D), and DHS signal (E) on H3K27ac super-enhancers and ERα ...
Bharath Saravanan (8232753) +11 more
core +1 more source
Neurobiological functions of transcriptional enhancers [PDF]
, 2020 Transcriptional enhancers are regulatory DNA elements that underlie the specificity and dynamic patterns of gene expression. Over the past decade, large-scale functional genomics projects have driven transformative progress in our understanding of ...
Nord, Alex S, West, Anne E
core +1 more source
Androgen Receptor-Mediated Transcription in Prostate Cancer
Cells, 2022 Androgen receptor (AR)-mediated transcription is critical in almost all stages of prostate cancer (PCa) growth and differentiation. This process involves a complex interplay of coregulatory proteins, chromatin remodeling complexes, and other ...
Doğancan Özturan +2 more
doaj +1 more source