Results 111 to 120 of about 24,141 (234)
Meteorin regulates mesendoderm development by enhancing nodal expression [PDF]
During gastrulation, distinct lineage specification into three germ layers, the mesoderm, endoderm and ectoderm, occurs through an elaborate harmony between signaling molecules along the embryonic proximo-distal and anterior-posterior axes, and Nodal ...
HAN, JIN KWAN +7 more
core +1 more source
Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors. [PDF]
, 2012 The pluripotent nature of human embryonic stem cells (hESCs) makes them convenient for deriving therapeutically relevant cells. Here we show using Wnt reporter hESC lines that the cells are heterogeneous with respect to endogenous Wnt signalling activity.
Ardehali, Reza +4 more
core +1 more source
Suppressing Nodal Signaling Activity Predisposes Ectodermal Differentiation of Epiblast Stem Cells
Stem Cell Reports, 2018 Summary: The molecular mechanism underpinning the specification of the ectoderm, a transient germ-layer tissue, during mouse gastrulation was examined here in a stem cell-based model.
Chang Liu +12 more
doaj
Molecular mechanism of symmetry breaking in a 3D model of a human epiblast
bioRxiv, 2018 Breaking the anterior-posterior (AP) symmetry in mammals takes place at gastrulation. Much of the signaling network underlying this process has been elucidated in the mouse, however there is no direct molecular evidence of events driving axis formation ...
M. Simunovic +8 more
semanticscholar +1 more source
Stem Cell Reports, 2023 Summary: Naive human pluripotent stem cells (hPSCs) are defined as the in vitro counterpart of the human preimplantation embryo’s epiblast and are used as a model system to study developmental processes.
Marta Moya-Jódar +13 more
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Pluripotency Potential of Embryonic Stem Cell-Like Cells Derived from Mouse Testis
Cell Journal, 2019 Objective: During the cultivation of spermatogonial stem cells (SSCs) and their conversion into embryonic stem-like (ES-like) cells, transitional ES-like colonies and epiblast-like cells were observable.
Hossein Azizi +2 more
doaj +1 more source
Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency
Nature Communications, 2016 Known molecular determinants of developmental plasticity are mainly transcription factors, while the extrinsic regulation of this process has been largely unexplored. Here we identify Cripto as one of the earliest epiblast markers and a key extracellular
Alessandro Fiorenzano +14 more
semanticscholar +1 more source
Cell Reports, 2017 Summary: The mouse inner cell mass (ICM) segregates into the epiblast and primitive endoderm (PrE) lineages coincident with implantation of the embryo. The epiblast subsequently undergoes considerable expansion of cell numbers prior to gastrulation.
Hisham Mohammed +11 more
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ZMYM2 inhibits NANOG-mediated reprogramming [version 1; peer review: 2 approved]
Wellcome Open Research, 2019 Background: NANOG is a homeodomain-containing transcription factor which forms one of the hubs in the pluripotency network and plays a key role in the reprogramming of somatic cells and epiblast stem cells to naïve pluripotency.
Moyra Lawrence +4 more
doaj +1 more source
Inverse agonism of retinoic acid receptors directs epiblast cells into the paraxial mesoderm lineage
Stem Cell Research, 2018 We have investigated the differentiation of paraxial mesoderm from mouse embryonic stem cells utilizing a Tbx6-EYFP/Brachyury (T)-Cherry dual reporter system.
Ryan P. Russell +3 more
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