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Biotechnology Advances, 2018
Recent studies have suggested that certain (-)-epicatechin-containing foods have a blood pressure-lowering capacity. The mechanisms underlying (-)-epicatechin action may help prevent oxidative damage and endothelial dysfunction, which have both been associated with hypertension and certain brain disorders.
Iveta Bernatova
exaly +3 more sources
Recent studies have suggested that certain (-)-epicatechin-containing foods have a blood pressure-lowering capacity. The mechanisms underlying (-)-epicatechin action may help prevent oxidative damage and endothelial dysfunction, which have both been associated with hypertension and certain brain disorders.
Iveta Bernatova
exaly +3 more sources
Uptake and metabolism of epicatechin and its access to the brain after oral ingestion
Free Radical Biology and Medicine, 2002 Epicatechin is a flavan-3-ol that is commonly present in green teas, red wine, cocoa products, and many fruits, such as apples. There is considerable interest in the bioavailability of epicatechin after oral ingestion. In vivo studies have shown that low
Hagen Schroeter +2 more
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Effect of Epicatechin on Skeletal Muscle
Current Medicinal Chemistry, 2022: Loss of skeletal muscle (SkM) quality is associated with different clinical conditions such as aging, diabetes, obesity, cancer, and heart failure. Nutritional research has focused on identifying naturally occurring molecules that mitigate the loss of SkM quality induced by pathology or syndrome. In this context, although few human studies have been
Hermann, Zbinden-Foncea +3 more
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Absorption and urinary excretion of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats
Free Radical Biology and Medicine, 2002We evaluated the bioavailability and plasma antioxidative activity after administration of procyanidin B2 [epicatechin-(4beta-8)-epicatechin] in rats. After procyanidin B2 administration, procyanidin B2 is absorbed and excreted in urine, and a portion of the PB2 is degraded to (-)-epicatechin and to the metabolized conjugated and/or methylated ...
Naomi Osakabe +2 more
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Absorption, metabolism, distribution and excretion of (−)-epicatechin: A review of recent findings
Molecular Aspects of Medicine, 2018 This paper reviews pioneering human studies, their limitations and recent investigations on the absorption, metabolism, distribution and excretion (aka bioavailability) of (–)-epicatechin.
Hagen Schroeter +2 more
exaly +2 more sources
Pharmacokinetics of (−)-epicatechin in rabbits
Archives of Pharmacal Research, 2009The aim of this study was to investigate the pharmacokinetics of (-)-epicatechin (EC) in rabbits after intravenous, intraperitoneal, and oral administration. A two-compartment model was used to describe the pharmacokinetics of EC after intravenous administration. EC showed dose-independent pharmacokinetics after intravenous administration. In addition,
Yen-An, Chen, Kuang-Yang, Hsu
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Molecular Nutrition and Food Research, 2016 Scope: Cocoa, rich in flavan-3-ols, improves vascular function, but the contribution of specific flavan-3-ols is unknown. We compared the effects of pure epicatechin, a major cocoa flavan-3-ol, and chocolate.
Johanna M. Geleijnse +2 more
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