Results 1 to 10 of about 208,159 (97)

Epigenetic age and neurodevelopmental outcomes in children born preterm [PDF]

Genetics in Medicine Open
Purpose: The objective of this study was to identify predictors of epigenetic age and its association with neurodevelopmental outcomes in children born preterm.
Rhandi Christensen, Chaini Konwar, Beryl C. Zhuang, Michael S. Kobor, Vann Chau, Anne Synnes, Ting Guo, Julia MacIsaac, Ruth E. Grunau, Steven P. Miller   +9 more
doaj   +2 more sources

EnsembleAge clock: a reliable and robust epigenetic age clock service reveals epigenetic age acceleration in opioid-overdosed brains [PDF]

BMC Genomics
Age is a major risk factor for various diseases, such as cancer, cardiovascular conditions, and neurodegenerative diseases. However, chronological age, the simple number of years one has lived, does not capture individual health differences, prompting ...
Akshay Anand, Yash Agarwal, Tanisha Gupta, Jason Lin, Mirna Ghemrawi, Glenn S. Gerhard, Hayan Lee   +6 more
doaj   +2 more sources

Associations between epigenetic age and brain age in young people [PDF]

Scientific Reports
Recent research suggests biological age, based on epigenetic or neuroimaging measures, may predict health traits in adulthood more accurately than chronological age. However, it is unclear if these findings apply earlier in life. We aimed to characterise
Faye Sanders, Vilte Baltramonaityte, Gary Donohoe, Neil M Davies, Erin C. Dunn, Charlotte A. M. Cecil, Esther Walton   +6 more
doaj   +2 more sources

Evaluation of Epigenetic Age Acceleration Scores and Their Associations with CVD-Related Phenotypes in a Population Cohort

Biology, 2022
We evaluated associations between nine epigenetic age acceleration (EAA) scores and 18 cardiometabolic phenotypes using an Eastern European ageing population cohort richly annotated for a diverse set of phenotypes (subsample, n = 306; aged 45–69 years ...
Olga Chervova, Elizabeth Chernysheva , Kseniia Panteleeva , Tyas Arum Widayati , Natalie Hrbkova, Jadesada Schneider , Vladimir Maximov , Andrew Ryabikov , Taavi Tillmann , Hynek Pikhart, Martin Bobak , Vitaly Voloshin , Sofia Malyutina , Stephan Beck    +13 more
doaj   +1 more source

DNA methylation age at birth and childhood: performance of epigenetic clocks and characteristics associated with epigenetic age acceleration in the Project Viva cohort

Clinical Epigenetics, 2023
Background Epigenetic age acceleration (EAA) and epigenetic gestational age acceleration (EGAA) are biomarkers of physiological development and may be affected by the perinatal environment.
Anne K. Bozack, Sheryl L. Rifas-Shiman, Diane R. Gold, Zachary M. Laubach, Wei Perng, Marie-France Hivert, Andres Cardenas   +6 more
doaj   +1 more source

Causal association of epigenetic aging and COVID-19 severity and susceptibility: A bidirectional Mendelian randomization study

Frontiers in Medicine, 2022
Observational data from China, the United States, France, and Italy suggest that chronological age is an adverse COVID-19 outcome risk factor, with older patients having a higher severity and mortality rate than younger patients. Most studies have gotten
Wenchang Xu, Wenchang Xu, Fengjun Zhang, Yingzhou Shi, Yuanzhen Chen, Bin Shi, Gongchang Yu   +6 more
doaj   +1 more source

Brain region-specific genome-wide deoxyribonucleic acid methylation analysis in patients with Alzheimer’s disease

Frontiers in Molecular Neuroscience, 2023
ObjectiveAlzheimer’s disease (AD) is a neurodegenerative disease characterized by neuropathology and cognitive decline and associated with age. The comprehensive deoxyribonucleic acid methylation (DNAm)-transcriptome profile association analysis ...
Gang Ren, Shan Song, Shan Song, Sheng-Xiao Zhang, Sheng-Xiao Zhang, Yan Liu, Yan Liu, Yan Lv, Yan-Hong Wang, Rong Zhao, Rong Zhao, Xin-Yi Li   +11 more
doaj   +1 more source

Accelerated epigenetic age and shortened telomere length based on DNA methylation in Nicolaides–Baraitser syndrome

Molecular Genetics & Genomic Medicine, 2022
Background Nicolaides–Baraitser syndrome (NCBRS) is a rare disorder characterized by neurodevelopmental delays, seizures, and diverse physical characteristics. The DNA methylation (DNAm) profile in NCBRS is significantly different.
Yutaka Shinko, Satoshi Okazaki, Ikuo Otsuka, Tadasu Horai, Saehyeon Kim, Takaki Tanifuji, Akitoyo Hishimoto   +6 more
doaj   +1 more source

Accelerated epigenetic aging and myopenia in young adult cancer survivors

Cancer Medicine, 2023
Background Young adult cancer survivors experience early aging‐related morbidities and mortality. Biological aging biomarkers may identify at‐risk survivors and increase our understanding of mechanisms underlying this accelerated aging.
Stephanie C. Gehle, Daniel Kleissler, Hillary Heiling, Allison Deal, Zongli Xu, Vanessa L. Ayer Miller, Jack A. Taylor, Andrew B. Smitherman   +7 more
doaj   +1 more source

The Blood DNA Methylation Clock GrimAge Is a Robust Surrogate for Airway Epithelia Aging

Biomedicines, 2022
One key feature of Chronic Obstructive Pulmonary Disease (COPD) is that its prevalence increases exponentially with age. DNA methylation clocks have become powerful biomarkers to detect accelerated aging in a variety of diseases and can help prognose ...
Ana I. Hernandez Cordero, Chen Xi Yang, Xuan Li, Julia Yang, Tawimas Shaipanich, Julie L. MacIsaac, David T. S. Lin, Michael S. Kobor, Steve Horvath, Shu Fan Paul Man, Don D. Sin, Janice M. Leung   +11 more
doaj   +1 more source