Results 11 to 20 of about 208,229 (162)
PLoS ONE, 2011 From the moment of conception, we begin to age. A decay of cellular structures, gene regulation, and DNA sequence ages cells and organisms. DNA methylation patterns change with increasing age and contribute to age related disease.
Sven Bocklandt +6 more
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Age reprogramming and epigenetic rejuvenation [PDF]
Epigenetics & Chromatin, 2018 Age reprogramming represents a novel method for generating patient-specific tissues for transplantation. It bypasses the de-differentiation/redifferentiation cycle that is characteristic of the induced pluripotent stem (iPS) and nuclear transfer ...
Prim B. Singh, Andrew G. Newman
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Identifying epigenetic aging moderators using the epigenetic pacemaker
Frontiers in BioinformaticsEpigenetic clocks are DNA methylation-based chronological age prediction models that are commonly employed to study age-related biology. The difference between the predicted and observed age is often interpreted as a form of biological age acceleration ...
Colin Farrell +5 more
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Epigenetic age prediction [PDF]
Aging Cell, 2021 AbstractAdvanced age is the main common risk factor for cancer, cardiovascular disease and neurodegeneration. Yet, more is known about the molecular basis of any of these groups of diseases than the changes that accompany ageing itself. Progress in molecular ageing research was slow because the tools predicting whether someone aged slowly or fast ...
Daniel J. Simpson, Tamir Chandra
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Current Genomics, 2015 The best-known phenomenon exemplifying epigenetic drift (the alteration of epigenetic patterns during aging) is the gradual decrease of global DNA methylation. Aging cells, different tissue types, as well as a variety of human diseases possess their own distinct DNA methylation profiles, although the functional impact of these is not always clear.
Sierra, Marta I. +2 more
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Science Advances, 2016 Researchers review how random changes and our environment (for example, diet) determines our life span.
Pal, Sangita, Tyler, Jessica K.
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Frontiers in Aging Neuroscience, 2022 Huntington’s disease (HD) is a dominantly inherited neurodegenerative disease with variable clinical manifestations. Recent studies highlighted the contribution of epigenetic alterations to HD progress and onset. The potential crosstalk between different
Soudeh Ghafouri-Fard +7 more
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Influence of obesity on biological age in patients with arterial hypertension
Arterial Hypertension, 2023 BACKGROUND: The aim of this study was to establish the relationship between metabolic disorders, overweight and obesity with markers of accelerated ageing in patients with hypertension.
Olena Kolesnikova +3 more
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Experimental Gerontology, 2010 Epigenetics is the field of study of phenotypic changes that may occur in a cell independent of changes in the underlying genetic code. In the strictest sense, these phenotypic changes are inherited and stable through rounds of DNA replication and cell division.
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Assessing brain and biological aging trajectories associated with Alzheimer’s disease
Frontiers in Neuroscience, 2022 The development of effective treatments to prevent and slow Alzheimer’s disease (AD) pathogenesis is needed in order to tackle the steady increase in the global prevalence of AD.
Winnie S. Liang +5 more
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