Results 21 to 30 of about 208,229 (162)

Epigenetic mechanisms in Tendon Ageing [PDF]

British Medical Bulletin, 2020
AbstractIntroductionTendon is a composite material with a well-ordered hierarchical structure exhibiting viscoelastic properties designed to transfer force. It is recognized that the incidence of tendon injury increases with age, suggesting a deterioration in homeostatic mechanisms or reparative processes.
Riasat, Kiran, Bardell, David, Goljanek-Whysall, Kasia, Clegg, Peter, Peffers, Mandy   +4 more
openaire   +4 more sources

Oocyte ageing and epigenetics [PDF]

REPRODUCTION, 2015
It has become a current social trend for women to delay childbearing. However, the quality of oocytes from older females is compromised and the pregnancy rate of older women is lower. With the increased rate of delayed childbearing, it is becoming more and more crucial to understand the mechanisms underlying the compromised quality of oocytes from ...
Ge, Zhao-Jia, Schatten, Heide, Zhang, Cui-Lian, Sun, Qing-Yuan   +3 more
openaire   +2 more sources

Prenatal and birth associations of epigenetic gestational age acceleration in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort

Epigenetics, 2022
Gestational age (GA) is an important determinant of child health and disease risk. Two epigenetic GA clocks have been developed using DNA methylation (DNAm) patterns in cord blood.
Saher Daredia, Karen Huen, Lars Van Der Laan, Philip A. Collender, Jamaji C. Nwanaji-Enwerem, Kim Harley, Julianna Deardorff, Brenda Eskenazi, Nina Holland, Andres Cardenas   +9 more
doaj   +1 more source

Early Pregnancy Exposure to Ambient Air Pollution among Late-Onset Preeclamptic Cases Is Associated with Placental DNA Hypomethylation of Specific Genes and Slower Placental Maturation

Toxics, 2021
Exposure to ambient air pollution during pregnancy has been associated with an increased risk of preeclampsia (PE). Some suggested mechanisms behind this association are changes in placental DNA methylation and gene expression.
Karin Engström, Yumjirmaa Mandakh, Lana Garmire, Zahra Masoumi, Christina Isaxon, Ebba Malmqvist, Lena Erlandsson, Stefan R. Hansson   +7 more
doaj   +1 more source

Clozapine Long-Term Treatment Might Reduce Epigenetic Age Through Hypomethylation of Longevity Regulatory Pathways Genes

Frontiers in Psychiatry, 2022
Long-term studies have shown significantly lower mortality rates in patients with continuous clozapine (CLZ) treatment than other antipsychotics. We aimed to evaluate epigenetic age and DNA methylome differences between CLZ-treated patients and those ...
Blanca Estela Pérez-Aldana, José Jaime Martínez-Magaña, Yerye Gibrán Mayén-Lobo, David José Dávila-Ortiz de Montellano, Carlos Luis Aviña-Cervantes, Alberto Ortega-Vázquez, Alma Delia Genis-Mendoza, Emmanuel Sarmiento, Ernesto Soto-Reyes, Isela Esther Juárez-Rojop, Carlos Alfonso Tovilla-Zarate, Thelma Beatriz González-Castro, Humberto Nicolini, Humberto Nicolini, Marisol López-López, Nancy Monroy-Jaramillo   +15 more
doaj   +1 more source

Epigenetics, aging, and autoimmunity [PDF]

Autoimmunity, 2008
Immune senescence is associated with a decline in T- and B-cell immune responses. It is, therefore, perhaps surprising that aging is linked to the appearance of serological and clinical autoimmunity. Here we review the mechanisms that contribute to the increase in inflammatory and autoimmune responses in aging.
Raymond L, Yung, Annabelle, Julius
openaire   +2 more sources

Epigenetic Clocks and Programmatic Aging

Ageing Research Reviews, 2023
The last decade has seen remarkable progress in the characterization of methylation clocks that track biological age in humans and many other mammalian species. While the biological processes of aging that underlie these clocks have remained unclear, several clues have pointed to a link to developmental mechanisms.
David Gems, Roop Singh Virk, João Pedro de Magalhães   +2 more
openaire   +2 more sources

Epigenetic aging of mammalian gametes

Molecular Reproduction and Development, 2023
AbstractThe process of aging refers to physiological changes that occur to an organism as time progresses and involves changes to DNA, proteins, metabolism, cells, and organs. Like the rest of the cells in the body, gametes age, and it is well established that there is a decline in reproductive capabilities in females and males with aging.
Michael Klutstein, Nitzan Gonen
openaire   +2 more sources

Epigenetic Control of Aging [PDF]

Antioxidants & Redox Signaling, 2011
Organismal aging and longevity are influenced by many complex interacting factors. Epigenetics has recently emerged as another possible determinant of aging. Here, we review some of the epigenetic pathways that contribute to cellular senescence and age-associated phenotypes.
Ursula, Muñoz-Najar, John M, Sedivy
openaire   +2 more sources

EPIGENETIC AGING AND RHEUMATOID ARTHRITIS

Innovation in Aging, 2023
Abstract Indicators of biological aging with rheumatoid arthritis (RA), a chronic autoimmune disease, are not yet fully known. In this cross-sectional study, we tested associations between plasma indicators of epigenetic aging using online data (GSE42861) regarding RA and DNA methylation from the Swedish Epidemiological Investigation of ...
Nandini Mukherjee, Tracie C Harrison
openaire   +2 more sources