Results 31 to 40 of about 208,229 (162)

Evaluation of Epigenetic Age Based on DNA Methylation Analysis of Several CpG Sites in Ukrainian Population

Frontiers in Genetics, 2022
Epigenetic clocks are the models, which use CpG methylation levels for the age prediction of an organism. Although there were several epigenetic clocks developed there is a demand for development and evaluation of the relatively accurate and sensitive ...
N. Kuzub, V. Smialkovska, V. Momot, V. Moseiko, O. Lushchak, A. Koliada, A. Koliada   +6 more
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Accelerated epigenetic age at birth and child emotional and behavioura development in early childhood: a meta-analysis of four prospective cohort studies in ECHO

Epigenetics, 2023
Background: ‘Epigenetic clocks’ have been developed to accurately predict chronologic gestational age and have been associated with child health outcomes in prior work. Methods: We meta-analysed results from four prospective U.S cohorts investigating the
Ashley Y. Song, Catherine M. Bulka, Sierra S. Niemiec, Katerina Kechris, Kristen E. Boyle, Carmen J. Marsit, T. Michael O’Shea, Rebecca C. Fry, Kristen Lyall, M. Daniele Fallin, Heather E. Volk, Christine Ladd-Acosta   +11 more
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Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration

Epigenetics, 2023
Early life is seen as a particularly sensitive period for environmental exposures. Natural space exposure during pregnancy has been associated with offspring health.
Irene Marques, Susana Santos, Giulietta S. Monasso, Serena Fossati, Martine Vrijheid, Mark Nieuwenhuijsen, Vincent W. V. Jaddoe, Janine F. Felix   +7 more
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Open access-enabled evaluation of epigenetic age acceleration in colorectal cancer and development of a classifier with diagnostic potential

Frontiers in Genetics, 2023
Aberrant DNA methylation (DNAm) is known to be associated with the aetiology of cancer, including colorectal cancer (CRC). In the past, the availability of open access data has been the main driver of innovative method development and research training ...
Tyas Arum Widayati, Jadesada Schneider, Jadesada Schneider, Kseniia Panteleeva, Elizabeth Chernysheva, Natalie Hrbkova, Stephan Beck, Vitaly Voloshin, Olga Chervova   +8 more
doaj   +1 more source

Maternal plasma fatty acid patterns in mid-pregnancy and offspring epigenetic gestational age at birth

Epigenetics, 2022
Maternal pregnancy fatty acid status is associated with child health. Epigenetic gestational age acceleration, referring to a discrepancy between chronological and epigenetic gestational age, may underlie these associations.
Giulietta S. Monasso, Trudy Voortman, Janine F. Felix   +2 more
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Maternal prenatal depression and epigenetic age deceleration: testing potentially confounding effects of prenatal stress and SSRI use

Epigenetics, 2021
Previous studies suggest epigenetic alterations may contribute to the association between maternal prenatal depression and adverse offspring outcomes. Developmental researchers have recently begun to examine these associations in relation to epigenetic ...
Brooke G. McKenna, Cassandra L. Hendrix, Patricia A. Brennan, Alicia K. Smith, Zachary N. Stowe, D. Jeffrey Newport, Anna K. Knight   +6 more
doaj   +1 more source

Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts

Epigenetics, 2019
Aging is associated with progressive and site-specific changes in DNA methylation (DNAm). These global changes are captured by DNAm clocks that accurately predict chronological age in humans but relatively little is known about how clocks perform in ...
Gabriel Sturm, Andres Cardenas, Marie-Abèle Bind, Steve Horvath, Shuang Wang, Yunzhang Wang, Sara Hägg, Michio Hirano, Martin Picard   +8 more
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Longitudinal study of epigenetic aging and its relationship with brain aging and cognitive skills in young adulthood

Frontiers in Aging Neuroscience, 2023
IntroductionThe proportion of older adults within society is sharply increasing and a better understanding of how we age starts to be critical. However, given the paucity of longitudinal studies with both neuroimaging and epigenetic data, it remains ...
Klara Mareckova, Klara Mareckova, Anna Pacinkova, Anna Pacinkova, Radek Marecek, Ludmila Sebejova, Lydie Izakovicova Holla, Jana Klanova, Milan Brazdil, Milan Brazdil, Yuliya S. Nikolova, Yuliya S. Nikolova   +11 more
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Prenatal gestational diabetes mellitus exposure and accelerated offspring DNA methylation age in early childhood

Epigenetics, 2021
Background: We investigated the association between prenatal GDM exposure and offspring DNA methylation (DNAm) age at 3–10 years of age in the Tianjin GDM Observational Study.
Stephanie Shiau, Leishen Wang, Huikun Liu, Yinan Zheng, Alex Drong, Brian T. Joyce, Jun Wang, Weiqin Li, Junhong Leng, Yun Shen, Ru Gao, Gang Hu, Lifang Hou, Andrea A. Baccarelli   +13 more
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Epigenetic clocks derived from western samples differentially reflect Taiwanese health outcomes

Frontiers in Genetics, 2023
Introduction: Several epigenetic clocks have been developed, with five measures of epigenetic age acceleration (EAA) especially receiving extensive investigations: HannumEAA, IEAA, PhenoEAA, GrimEAA, and DunedinPACE.
Wan-Yu Lin, Wan-Yu Lin, Wan-Yu Lin
doaj   +1 more source