Results 41 to 50 of about 208,229 (162)
Translational Andrology and Urology, 2018 Advanced paternal age has very real consequences in fertility, embryogenesis, and even offspring health. Specifically, advanced paternal age has been linked to delayed time to pregnancy and in some studies even appears to be linked to a decreased likelihood of achieving a pregnancy.
Jenkins, Timothy G. +2 more
openaire +2 more sources
BayesAge: A maximum likelihood algorithm to predict epigenetic age
Frontiers in BioinformaticsIntroduction: DNA methylation, specifically the formation of 5-methylcytosine at the C5 position of cytosine, undergoes reproducible changes as organisms age, establishing it as a significant biomarker in aging studies. Epigenetic clocks, which integrate
Lajoyce Mboning +4 more
doaj +1 more source
Frontiers in AgingIntroductionDNA methylation (DNAm) age clocks are powerful tools for measuring biological age, providing insights into aging risks and outcomes beyond chronological age.
David Martínez-Enguita +5 more
doaj +1 more source
GLOBAL JOURNAL FOR RESEARCH ANALYSIS, 2020 Aging is an inevitable Biological phenomenon determined by genetic and epigenetic processes. Various studies have indicated aging is associated with progressive changes in epigenetics. Epigenetics is a dynamic process like aging and is affected by DNA methylation, histone acetylation, post translational modifications of histone proteins and varied non-
Anjali S Ghatge +5 more
openaire +1 more source
Epigenetic aging in adult neurogenesis
Hippocampus, 2023 AbstractNeural stem cells (NSCs) in the hippocampus generate new neurons throughout life, which functionally contribute to cognitive flexibility and mood regulation. Yet adult hippocampal neurogenesis substantially declines with age and age‐related impairments in NSC activity underlie this reduction.
Zocher, Sara, Toda, Tomohisa
openaire +4 more sources
Epigenetic alterations in aging
Journal of Applied Physiology, 2010 Aging is a multifaceted process characterized by genetic and epigenetic changes in the genome. The genetic component of aging received initially all of the attention. Telomere attrition and accumulation of mutations due to a progressive deficiency in the repair of DNA damage with age remain leading causes of genomic instability.
openaire +3 more sources
Psychosocial stress and epigenetic aging [PDF]
, 2020 Aging is the single most important risk factor for diseases that are currently the leading causes of morbidity and mortality. However, there is considerable inter-individual variability in risk for aging-related disease, and studies suggest that biological age can be influenced by multiple factors, including exposure to psychosocial stress.
Palma-Gudiel, Helena +3 more
openaire +3 more sources
, 2018 Acceso cerrado a este documento. No se encuentra disponible para la consulta pública. Depositado en Academica-e para cumplir con los requisitos de evaluación y acreditación académica del autor/a (sexenios, acreditaciones, etc.).
Cacabelos, Ramón +1 more
openaire +2 more sources
Epigenetics & Chromatin, 2022 Background The epigenetic age can now be extrapolated from one of several epigenetic clocks, which are based on age-related changes in DNA methylation levels at specific multiple CpG sites.
Tamar Shahal +9 more
doaj +1 more source
New insights into methods to measure biological age: a literature review
Frontiers in AgingBiological age is a concept that reflects the physiological state of an individual rather than the chronological time since birth. It can help assess the risk of age-related diseases and mortality and the effects of interventions to slow down or reverse ...
Aanchal Mathur +2 more
doaj +1 more source