Results 31 to 40 of about 6,200 (160)
Epigenetics, 2022 Epigenetic clocks quantify regular changes in DNA methylation that occur with age, or in relation to biomarkers of ageing, and are strong predictors of morbidity and mortality.
Christopher W. Kuzawa +9 more
doaj +1 more source
Effect of metformin on the epigenetic age of peripheral blood in patients with diabetes mellitus
Frontiers in Genetics, 2022 Background: Metformin has been proven to have an antiaging effect. However, studies on how metformin affects global epigenetic regulation and its effect on the epigenetic clock in diabetes mellitus (DM) patients are limited.
Man Li, Litao Bao, Ping Zhu, Shuxia Wang
doaj +1 more source
Calibrating epigenetic clocks with training data error
Evolutionary Applications, 2023 AbstractAnimal age data are valuable for management of wildlife populations. Yet, for most species, there is no practical method for determining the age of unknown individuals. However, epigenetic clocks, a molecular‐based method, are capable of age prediction by sampling specific tissue types and measuring DNA methylation levels at specific loci ...
Benjamin Mayne +2 more
openaire +3 more sources
BMC MedicineBackground Epigenetic clocks were known as promising biomarkers of aging, including original clocks trained by individual CpG sites and principal component (PC) clocks trained by PCs of CpG sites.
Ke Miao +16 more
doaj +1 more source
Blood transcriptomic associations of epigenetic age in adolescents
EpigeneticsEpigenetic aging in early life remains poorly characterized, and patterns of gene expression can provide biologically meaningful insights. Blood DNA methylation was measured using the Illumina EPICv1.0 array and RNA sequencing was performed in blood in ...
Dennis Khodasevich +8 more
doaj +1 more source
Epigenetics, 2023 Co-occurrence of injection drug use (IDU) and hepatitis C virus infection (HCV) is common in people living with HIV (PLWH) and leads to significantly increased mortality.
Xiaoyu Liang +4 more
doaj +1 more source
Frontiers in Genetics, 2022 Epigenetic clocks are the models, which use CpG methylation levels for the age prediction of an organism. Although there were several epigenetic clocks developed there is a demand for development and evaluation of the relatively accurate and sensitive ...
N. Kuzub +6 more
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Epigenetic clock analysis in long-term meditators [PDF]
Psychoneuroendocrinology, 2017 In this paper, we examined whether meditation practice influences the epigenetic clock, a strong and reproducible biomarker of biological aging, which is accelerated by cumulative lifetime stress and with age-related chronic diseases. Using the Illumina 450K array platform, we analyzed the DNA methylome from blood cells of long-term meditators and ...
Chaix, Raphaëlle +7 more
openaire +3 more sources
Transfer Elastic Net for Developing Epigenetic Clocks for the Japanese Population
MathematicsThe epigenetic clock evaluates human biological age based on DNA methylation patterns. It takes the form of a regression model where the methylation ratio at CpG sites serves as the predictor and age as the response variable.
Yui Tomo, Ryo Nakaki
doaj +1 more source
Frontiers in Genetics, 2022 The host epigenetic landscape rapidly changes during SARS-CoV-2 infection, and evidence suggest that severe COVID-19 is associated with durable scars to the epigenome.
Alina P. S. Pang +15 more
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