Results 51 to 60 of about 6,200 (160)

A new timepiece: an epigenetic mitotic clock

Genome Biology, 2016
A new mitotic clock and mathematical approach that incorporates DNA methylation biology common among human cell types provides a new tool for cancer epigenetics research.
Christensen, Brock C., Kelsey, Karl T.
openaire   +2 more sources

Development of an epigenetic clock resistant to changes in immune cell composition

Communications Biology
Epigenetic clocks are age predictors that use machine-learning models trained on DNA CpG methylation values to predict chronological or biological age. Increases in predicted epigenetic age relative to chronological age (epigenetic age acceleration) are ...
Alan Tomusiak, Ariel Floro, Ritesh Tiwari, Rebeccah Riley, Hiroyuki Matsui, Nicolas Andrews, Herbert G. Kasler, Eric Verdin   +7 more
doaj   +1 more source

Critical review of aging clocks and factors that may influence the pace of aging

Frontiers in Aging
Background and objectivesAging clocks are computational models designed to measure biological age and aging rate based on age-related markers including epigenetic, proteomic, and immunomic changes, gut and skin microbiota, among others. In this narrative
Mildred Min, Mildred Min, Mildred Min, Caitlin Egli, Caitlin Egli, Caitlin Egli, Ajay S. Dulai, Ajay S. Dulai, Raja K. Sivamani, Raja K. Sivamani, Raja K. Sivamani, Raja K. Sivamani, Raja K. Sivamani   +12 more
doaj   +1 more source

Abnormal epigenetic aging of epigenetic outliers in normal colon mucosa from colorectal cancer patients

Scientific Reports
A subset of colorectal cancer (CRC) patients displays abnormal DNA methylation patterns (“Outlier Methylation Phenotype” (OMP)) in normal adjacent tissue (NAT).
Bryant M. Schultz, Olorunfemi Ayeotan, Juie N. Rana, Samuel Litwin, Stanley Basickes, Carmen Sapienza, Jayashri Ghosh   +6 more
doaj   +1 more source

Mutation and epigenetic molecular clocks in cancer [PDF]

Carcinogenesis, 2010
A quandary of evolution is how to measure change over time. A natural inclination is to use morphologic criteria-the greater the differences between two phenotypes, the greater amount of time needed to evolve these differences. However, appearances may be deceiving, and another approach to infer time is with molecular clocks.
openaire   +2 more sources

Mendelian randomization implicates causal association between epigenetic age acceleration and age-related eye diseases or glaucoma endophenotypes

Clinical Epigenetics
Background Age-related eye diseases (AREDs) have become increasingly prevalent with the aging population, serving as the leading causes of visual impairment worldwide.
Jiawei Chen, Xiang-Ling Yuan, Xiaoyu Zhou, Jiahao Xu, Xinyue Zhang, Xuanchu Duan   +5 more
doaj   +1 more source

Differential white blood cell count and epigenetic clocks: a bidirectional Mendelian randomization study

Clinical Epigenetics
Background Human aging and white blood cell (WBC) count are complex traits influenced by multiple genetic factors. Predictors of chronological age have been developed using epigenetic clocks.
Manli Sun, Huan Yang, Yang Hu, Jiaqi Fan, Mingjing Duan, Jingqi Ruan, Shichang Li, Yang Xu, Yue Han   +8 more
doaj   +1 more source

A SuperLearner-based pipeline for the development of DNA methylation-derived predictors of phenotypic traits.

PLoS Computational Biology
BackgroundDNA methylation (DNAm) provides a window to characterize the impacts of environmental exposures and the biological aging process. Epigenetic clocks are often trained on DNAm using penalized regression of CpG sites, but recent evidence suggests ...
Dennis Khodasevich, Nina Holland, Lars van der Laan, Andres Cardenas   +3 more
doaj   +1 more source

Epigenetic clocks and gliomas: unveiling the molecular interactions between aging and tumor development

Frontiers in Molecular Biosciences
Gliomas, the most prevalent and aggressive primary brain tumors, represent a diverse group of malignancies originating from glial cells. These tumors account for significant brain tumor-related morbidity and mortality, with higher incidence rates in ...
Shiliang Chen, Yi Jiang, Cong Wang, Shiyuan Tong, Yibo He, Wenqiang Lu, Zhezhong Zhang   +6 more
doaj   +1 more source

An epigenetic clock for Xenopus tropicalis

npj Aging
Abstract DNA methylation clocks have been widely used for accurate age prediction, but most studies have been carried out on mammals. Here we present an epigenetic clock for the aquatic frog Xenopus tropicalis, a widely used model organism in developmental biology and genomics.
Bennett, Ronan, Morselli, Marco, Petrova, Kseniya, Peshkin, Leonid, Pellegrini, Matteo   +4 more
openaire   +2 more sources