Results 1 to 10 of about 2,264,000 (323)

Epigenetic modification in Parkinson’s disease [PDF]

Frontiers in Cell and Developmental Biology, 2023
Parkinson’s disease (PD) is a common neurodegenerative disorder caused by genetic, epigenetic, and environmental factors. Recent advance in genomics and epigenetics have revealed epigenetic mechanisms in PD.
Hao Song, Hao Song, Juanli Chen, Jin Huang, Peng Sun, Yanming Liu, Li Xu, Chuanfei Wei, Xin Mu, Xianjie Lu, Wei Wang, Nan Zhang, Miwei Shang, Mei Mo, Wei Zhang, Hui Zhao, Fabin Han, Fabin Han   +17 more
doaj   +5 more sources

Epigenetic modification in liver fibrosis: Promising therapeutic direction with significant challenges ahead

Acta Pharmaceutica Sinica B, 2023
Liver fibrosis, characterized by scar tissue formation, can ultimately result in liver failure. It's a major cause of morbidity and mortality globally, often associated with chronic liver diseases like hepatitis or alcoholic and non-alcoholic fatty liver
Runping Liu, Yajing Li, Qi Zheng, Mingning Ding, Huiping Zhou, Xiaojiaoyang Li   +5 more
doaj   +2 more sources

Epigenetic modification and BRAF gene mutation in thyroid carcinoma

Cancer Cell International, 2021
Thyroid cancer remains the most prevailing endocrine malignancy, and a progressively increasing incidence rate has been observed in recent years, with 95% of thyroid cancer represented by differentiated thyroid carcinomas. The genetics and epigenetics of
Guo Huang, Juan Chen, Jun Zhou, Shuai Xiao, Weihong Zeng, Jiliang Xia, Xi Zeng   +6 more
doaj   +2 more sources

Epigenetic modification in diabetic kidney disease

Frontiers in Endocrinology, 2023
Diabetic kidney disease (DKD) is a common microangiopathy in diabetic patients and the main cause of death in diabetic patients. The main manifestations of DKD are proteinuria and decreased renal filtration capacity.
Zhe Liu, Zhe Liu, Jiahui Liu, Wanning Wang, Xingna An, Ling Luo, Dehai Yu, Weixia Sun   +7 more
doaj   +2 more sources

The epigenetic modification of DNA methylation in neurological diseases. [PDF]

Front Immunol
Methylation, a key epigenetic modification, is essential for regulating gene expression and protein function without altering the DNA sequence, contributing to various biological processes, including gene transcription, embryonic development, and ...
Li L, Chen R, Zhang H, Li J, Huang H, Weng J, Tan H, Guo T, Wang M, Xie J.   +9 more
europepmc   +2 more sources

Epigenetic regulation of diverse cell death modalities in cancer: a focus on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis

Journal of Hematology & Oncology
Tumor is a local tissue hyperplasia resulted from cancerous transformation of normal cells under the action of various physical, chemical and biological factors.
Shimeng Zhou, Junlan Liu, Andi Wan, Yi Zhang, Xiaowei Qi   +4 more
doaj   +2 more sources

Editorial: Epigenetic modification in neurological diseases [PDF]

Frontiers in Genetics
Mojgan Rastegar
doaj   +2 more sources

Epigenetic modification of m6A regulator proteins in cancer

Molecular Cancer, 2023
Divergent N_6-methyladenosine (m^6A) modifications are dynamic and reversible posttranscriptional RNA modifications that are mediated by m^6A regulators or m^6A RNA methylation regulators, i.e., methyltransferases (“writers”), demethylases (“erasers ...
Yumin Wang, Yan Wang, Harsh Patel, Jichao Chen, Jinhua Wang, Zhe‐Sheng Chen, Hongquan Wang   +6 more
semanticscholar   +1 more source

Epigenetic modifications in the accumulation and function of myeloid-derived suppressor cells

Frontiers in Immunology, 2022
Myeloid-derived suppressor cells (MDSCs) are key players under various pathologic conditions, such as cancer. Epigenetic modifications such as DNA methylation, RNA-mediated processes, and histone modification can alter gene transcription, and thus ...
Liangjie Xu, Cuicui Zhou, Yi Liang, Tinpan Fan, Fen Zhang, Xinxin Chen, Wei Yuan   +6 more
doaj   +1 more source

Development and Validation of Epigenetic Modification-Related Signals for the Diagnosis and Prognosis of Hepatocellular Carcinoma

Frontiers in Oncology, 2021
BackgroundIncreasing evidence has indicated that abnormal epigenetic factors such as RNA m6A modification, histone modification, DNA methylation, RNA binding proteins and transcription factors are correlated with hepatocarcinogenesis.
Maoqing Lu, Sheng Qiu, Xianyao Jiang, Diguang Wen, Ronggui Zhang, Zuojin Liu   +5 more
doaj   +1 more source