Results 21 to 30 of about 2,264,000 (323)
Epigenetic Modification Drives Acute Kidney Injury-to-Chronic Kidney Disease Progression
Nephron, 2021 Acute kidney injury (AKI) is a common clinical critical disease. Due to its high morbidity, increasing risk of complications, high mortality rate, and high medical costs, it has become a global concern for human health problems.
Zhenzhen Li, Ningning Li
semanticscholar +1 more source
Epigenetic modifications in neuropathic pain [PDF]
Molecular Pain, 2021 Neuropathic pain (NP) is a common symptom in many diseases of the somatosensory nervous system, which severely affects the patient’s quality of life. Epigenetics are heritable alterations in gene expression that do not cause permanent changes in the DNA sequence.
Danzhi Luo +7 more
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Crosstalk between epigenetic modification and circRNA in colorectal cancer: recent advances
Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Colorectal cancer (CRC) is generally regarded as the third frequent malignancy worldwide, while current diagnosis and treatment of the disease are limited.
PENG Tian, XU Leiming
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Non-mammalian model organisms in epigenetic research : an overview [PDF]
, 2020 Recent advances in sequencing technology and genome editing tools had an indisputably enormous impact on our understanding of complex biological pathways and their genetic and epigenetic regulation.
Baruah, Sri Kartik +3 more
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Transcription factors direct epigenetic reprogramming at specific loci in human cancers
Frontiers in Genetics, 2023 The characterization of epigenetic changes during cancer development and progression led to notable insights regarding the roles of cancer-specific epigenetic reprogramming.
Han Jiang, Guoxin Li
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8-Oxoguanine: from oxidative damage to epigenetic and epitranscriptional modification
Experimental and Molecular Medicine, 2022 In pathophysiology, reactive oxygen species control diverse cellular phenotypes by oxidizing biomolecules. Among these, the guanine base in nucleic acids is the most vulnerable to producing 8-oxoguanine, which can pair with adenine.
J. Hahm +3 more
semanticscholar +1 more source
Small-Molecule Inhibitors Overcome Epigenetic Reprogramming for Cancer Therapy
Frontiers in Pharmacology, 2021 Cancer treatment is a significant challenge for the global health system, although various pharmacological and therapeutic discoveries have been made.
Wenjing Xiao +11 more
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Readout of Epigenetic Modifications [PDF]
Annual Review of Biochemistry, 2013 This review focuses on a structure-based analysis of histone posttranslational modification (PTM) readout, where the PTMs serve as docking sites for reader modules as part of larger complexes displaying chromatin modifier and remodeling activities, with the capacity to alter chromatin architecture and templated processes.
Dinshaw J, Patel, Zhanxin, Wang
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Epigenetic Modifications [PDF]
Circulation, 2011 The term epigenetics was first used to refer to the complex interactions between the genome and the environment that are involved in development and differentiation in higher organisms. Today, this term is used to refer to heritable alterations that are not due to changes in DNA sequence.
Diane E, Handy +2 more
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Frontiers in Physiology, 2023 Skeletal muscles, the largest organ responsible for energy metabolism in most mammals, play a vital role in maintaining the body’s homeostasis.
Junjie Xu, Chenglong Li, Xiaolong Kang
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