Results 1 to 10 of about 87,804 (313)

Clinical application of liquid biopsy in cancer patients

BMC Cancer, 2022
Background This study was to determine the prevalence and clinical significance of clonal hematopoiesis (CH)-related variants, and somatic and germline mutations in cancer patients and healthy individuals.
Chieh-Min Chang, Kuei-Ching Lin, Nien-En Hsiao, Wei-An Hong, Chia-Yu Lin, Ta-Chih Liu, Ya-Sian Chang, Jan-Gowth Chang   +7 more
doaj   +1 more source

Therapeutic and immunomodulatory potential of pazopanib in malignant phyllodes tumor

npj Breast Cancer, 2022
Malignant phyllodes tumors (PT) are rare aggressive fibroepithelial neoplasms with high metastatic potential and lack effective therapy. We established a patient-derived xenograft (PDX) and cell line model (designated MPT-S1) of malignant PT which ...
Dave Yong Xiang Ng, Zhimei Li, Elizabeth Lee, Jessica Sook Ting Kok, Jing Yi Lee, Joanna Koh, Cedric Chuan-Young Ng, Abner Herbert Lim, Wei Liu, Sheng Rong Ng, Kah Suan Lim, Xi Xiao Huang, Jing Han Hong, Peiyong Guan, Yirong Sim, Aye Aye Thike, Nur Diyana Md Nasir, Shang Li, Puay Hoon Tan, Bin Tean Teh, Jason Yongsheng Chan   +20 more
doaj   +1 more source

Cell-Free miR-27a, a Potential Diagnostic and Prognostic Biomarker for Gastric Cancer [PDF]

Genomics & Informatics, 2015
MicroRNAs (miRNAs) have been demonstrated to play an important role in carcinogenesis. Previous studies revealed that miRNAs are present in human plasma in a remarkably stable form that is protected from endogenous RNase activity.
Jong-Lyul Park, Mirang Kim, Kyu-Sang Song, Seon-Young Kim, Yong Sung Kim   +4 more
doaj   +1 more source

Concurrent mapping of multiple epigenetic marks and co-occupancy using ACT2-seq

Cell & Bioscience, 2021
Background Genome-wide profiling of epigenetic marks is a core technology in molecular genetics. Co-occupancy of different epigenetic marks or protein factors at the same genomic locations must often be inferred from multiple independently collected data
Benjamin Carter, Wai Lim Ku, Joe Pelt, Keji Zhao   +3 more
doaj   +1 more source

Mutation profile of non-small cell lung cancer revealed by next generation sequencing

Respiratory Research, 2021
Background Precision therapy for lung cancer requires comprehensive genomic analyses. Specific effects of targeted therapies have been reported in Asia populations, including Taiwanese, but genomic studies have rarely been performed in these populations.
Ya-Sian Chang, Siang-Jyun Tu, Yu-Chia Chen, Ting-Yuan Liu, Ya-Ting Lee, Ju-Chen Yen, Hsin-Yuan Fang, Jan-Gowth Chang   +7 more
doaj   +1 more source

Infection of Brain Organoids and 2D Cortical Neurons with SARS-CoV-2 Pseudovirus

Viruses, 2020
Since the global outbreak of SARS-CoV-2 (COVID-19), infections of diverse human organs along with multiple symptoms continue to be reported. However, the susceptibility of the brain to SARS-CoV-2, and the mechanisms underlying neurological infection are ...
Sang Ah Yi, Ki Hong Nam, Jihye Yun, Dongmin Gim, Daeho Joe, Yong Ho Kim, Han-Joo Kim, Jeung-Whan Han, Jaecheol Lee   +8 more
doaj   +1 more source

Multiregion sequencing of sarcomatoid renal cell carcinoma arising from autosomal dominant polycystic kidney disease

Molecular Genetics & Genomic Medicine, 2022
Background Autosomal dominant polycystic kidney disease (ADPKD) is an inherited cystic kidney disease associated with a spectrum of various renal and extrarenal manifestations, including increased risk of kidney cancers.
Elizabeth Lee, Peiyong Guan, Abner Herbert Lim, Jui Wan Loh, Grace Fangmin Tan, Tracy Loh, Dave Yong Xiang Ng, Jing Yi Lee, Shane Goh, Wei Liu, Cedric Chuan‐Young Ng, Bin Tean Teh, Jason Yongsheng Chan   +12 more
doaj   +1 more source

Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study

Arthritis Research & Therapy, 2022
Background Gout is a highly hereditary disease, but not all those carrying well-known risk variants have developing gout attack even in hyperuricemia status.
Ya-Sian Chang, Chien-Yu Lin, Ting-Yuan Liu, Chung-Ming Huang, Chin-Chun Chung, Yu-Chia Chen, Fuu-Jen Tsai, Jan-Gowth Chang, Shun-Jen Chang   +8 more
doaj   +1 more source

scPCOR-seq enables co-profiling of chromatin occupancy and RNAs in single cells

Communications Biology, 2022
scPCOR-seq is a single-cell sequencing technique that enables simultaneous profiling of genome-wide chromatin protein binding or histone modification marks and RNA expression in the same cell.
Lixia Pan, Wai Lim Ku, Qingsong Tang, Yaqiang Cao, Keji Zhao   +4 more
doaj   +1 more source

Hi-TrAC reveals division of labor of transcription factors in organizing chromatin loops

Nature Communications, 2022
It is currently not clear how architectural proteins orchestrate chromatin looping at different scales of genome organisation. Here the authors report Hi-TrAC as a proximity ligation-free method to profile genome-wide chromatin interactions at single ...
Shuai Liu, Yaqiang Cao, Kairong Cui, Qingsong Tang, Keji Zhao   +4 more
doaj   +1 more source