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Genomic Medicine, 2008 'Epigenomics' can be termed as the study of the effects of chromatin structure, including the higher order of chromatin folding and attachment to the nuclear matrix, packaging of DNA around nucleosomes, covalent modifications of histone tails and DNA methylation. This has evolved to include any process that alters gene activity without changing the DNA
Virendra S, Gomase, Somnath, Tagore
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Environmental Epigenomes [PDF]
Epigenomes, 2023 Research in epigenetics has dramatically risen during the last decade to include aspects of environmental biology. However, many questions remain regarding the effects of environmental stressors on the epigenome, incorporating the particular role of epigenetic mechanisms in the adaptation and evolution of organisms in changing environments. Epigenetics
Bambarendage P. U. Perera +1 more
openaire +4 more sources
Circulation Research, 2018 The advent of high-throughput epigenome mapping technologies has ushered in a new era of multiomics where powerful tools can now delineate and record different layers of genomic output. Integrating various components of the epigenome from these multiomics measurements allows the interrogation of cellular heterogeneity in addition to the discovery of ...
Kevin C, Wang, Howard Y, Chang
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Clinical application of liquid biopsy in cancer patients
BMC Cancer, 2022 Background This study was to determine the prevalence and clinical significance of clonal hematopoiesis (CH)-related variants, and somatic and germline mutations in cancer patients and healthy individuals.
Chieh-Min Chang +7 more
doaj +1 more source
Nature Reviews Immunology, 2021 A new study in Cell provides a single-cell map of the epigenetic and transcriptomic landscape in response to influenza vaccination, revealing persistent epigenomic remodelling in myeloid cells and the antiviral effects of adjuvant.
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Therapeutic and immunomodulatory potential of pazopanib in malignant phyllodes tumor
npj Breast Cancer, 2022 Malignant phyllodes tumors (PT) are rare aggressive fibroepithelial neoplasms with high metastatic potential and lack effective therapy. We established a patient-derived xenograft (PDX) and cell line model (designated MPT-S1) of malignant PT which ...
Dave Yong Xiang Ng +20 more
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Cell-Free miR-27a, a Potential Diagnostic and Prognostic Biomarker for Gastric Cancer [PDF]
Genomics & Informatics, 2015 MicroRNAs (miRNAs) have been demonstrated to play an important role in carcinogenesis. Previous studies revealed that miRNAs are present in human plasma in a remarkably stable form that is protected from endogenous RNase activity.
Jong-Lyul Park +4 more
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Concurrent mapping of multiple epigenetic marks and co-occupancy using ACT2-seq
Cell & Bioscience, 2021 Background Genome-wide profiling of epigenetic marks is a core technology in molecular genetics. Co-occupancy of different epigenetic marks or protein factors at the same genomic locations must often be inferred from multiple independently collected data
Benjamin Carter +3 more
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Infection of Brain Organoids and 2D Cortical Neurons with SARS-CoV-2 Pseudovirus
Viruses, 2020 Since the global outbreak of SARS-CoV-2 (COVID-19), infections of diverse human organs along with multiple symptoms continue to be reported. However, the susceptibility of the brain to SARS-CoV-2, and the mechanisms underlying neurological infection are ...
Sang Ah Yi +8 more
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Mutation profile of non-small cell lung cancer revealed by next generation sequencing
Respiratory Research, 2021 Background Precision therapy for lung cancer requires comprehensive genomic analyses. Specific effects of targeted therapies have been reported in Asia populations, including Taiwanese, but genomic studies have rarely been performed in these populations.
Ya-Sian Chang +7 more
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