Results 111 to 120 of about 21,621 (295)

DNA methylation profiles unique to Kalahari KhoeSan individuals

Epigenetics, 2021
Genomes of KhoeSan individuals of the Kalahari Desert provide the greatest understanding of single nucleotide diversity in the human genome. Compared with individuals in industrialized environments, the KhoeSan have a unique foraging and hunting ...
Alexander Goncearenco, Brenna A. LaBarre, Hanna M. Petrykowska, Weerachai Jaratlerdsiri, M. S. Riana Bornman, Stephen D. Turner, Vanessa M. Hayes, Laura Elnitski   +7 more
doaj   +1 more source

Deregulated enhancer‐promoter communication in cancer through altered nuclear architecture

International Journal of Cancer, EarlyView.
Abstract Enhancers are critical regulators of gene expression. Structural variations in cancer genomes can lead to enhancer hijacking, where oncogenes are activated by mistargeted enhancer activity. Novel enhancer‐promoter interactions may also arise through chromosomal rearrangements that create extrachromosomal DNA elements.
Isabelle Seufert, Claire Vargas, Sina Jasmin Wille, Karsten Rippe   +3 more
wiley   +1 more source

The Epigenomics of Pituitary Adenoma

Frontiers in Endocrinology, 2019
Background: The vast majority of pituitary tumors are benign and behave accordingly; however, a fraction are invasive and are more aggressive, with a very small fraction being frankly malignant.
Blake M. Hauser, Ashley Lau, Saksham Gupta, Wenya Linda Bi, Ian F. Dunn   +4 more
doaj   +1 more source

Epigenetic reprogramming in multiple myeloma—Challenges and opportunities

International Journal of Cancer, EarlyView.
Abstract In cancer, mutational processes act in concert with epigenetic reprogramming to endow malignant cells with hallmark properties that underpin tumorigenesis. Compared with the relatively rigid and slow processes of genetic evolution, the plastic nature of chromatin enables cells to adapt to a changing environment more rapidly.
Subhasree Kumar, Lev M. Kats, Emily Gruber   +2 more
wiley   +1 more source

Reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer

Cell Reports, 2021
Summary: This study addresses the roles of nuclear receptor corepressor 2 (NCOR2) in prostate cancer (PC) progression in response to androgen deprivation therapy (ADT).
Mark D. Long, Justine J. Jacobi, Prashant K. Singh, Gerard Llimos, Sajad A. Wani, Aryn M. Rowsam, Spencer R. Rosario, Marlous Hoogstraat, Simon Linder, Jason Kirk, Hayley C. Affronti, Andries Bergman, Wilbert Zwart, Moray J. Campbell, Dominic J. Smiraglia   +14 more
doaj  

Crop improvement using life cycle datasets acquired under field conditions

Frontiers in Plant Science, 2015
Crops are exposed to various environmental stresses in the field throughout their life cycle. Modern plant science has provided remarkable insights into the molecular networks of plant stress responses in laboratory conditions, but the responses of ...
Keiichi eMochida, Keiichi eMochida, Daisuke eSaisho, Takashi eHirayama   +3 more
doaj   +1 more source

Ascites of patients with solid tumors shows distinct inflammatory patterns

Cancer Communications, EarlyView.
Julia M. Berger, Martin Korpan, Carina Zierfuss, Katharina Syböck, Erwin Tomasich, Andreas Kienzle, Maria Koenig, Markus Kleinberger, Lynn Gottmann, Birgit Fendl, Cihan Ay, Johannes Pammer, Catharina Müller, Rudolf Oehler, Lorenz Balcar, Thomas Reiberger, Elisabeth S. Bergen, Barbara Niederdorfer, Matthias Preusser, Anna S. Berghoff   +19 more
wiley   +1 more source

Early‐life anthropometry and colorectal cancer risk in adulthood: Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis of prospective studies

International Journal of Cancer, EarlyView.
What's New? While adult anthropometry is linked to colorectal cancer (CRC) risk, associations between anthropometric measures across early‐life stages and CRC risk remain unclear. In this study, the authors systematically reviewed and meta‐analysed early‐life anthropometry and adult CRC risk across early‐life stages.
Moniek van Zutphen, Auke J. C. F. Verkaar, Fränzel J. B. van Duijnhoven, Trudy Voortman, Monica L. Baskin, Rajiv Chowdhury, Ellen Copson, Sarah J. Lewis, Lynette Hill, John Krebs, Matty P. Weijenberg, Jacob C. Seidell, Yikyung Park, Jennifer L. Baker, Mojgan Amiri, Tosca O. E. de Crom, Erand Llanaj, Amber Meulenbeld, Macarena Lara, Yuchan Mou, Vanessa L. Z. Gordon‐Dseagu, Esther M. González‐Gil, Georgios Markozannes, Konstantinos K. Tsilidis, Doris S. M. Chan, Ellen Kampman, Dieuwertje E. Kok   +26 more
wiley   +1 more source

Histone variant H3.3 and its future prospects in cancer clinic

Journal of Radiation and Cancer Research, 2017
Histone variant, H3.3 has been a continuous subject of interest in the field of chromatin studies due to its two distinguishing features. First, its incorporation into chromatin is replication-independent, unlike the replication-coupled deposition of its
Divya Reddy, Sanjay Gupta
doaj   +1 more source

Molecular subtyping and precision therapy for esophageal cancer

Interdisciplinary Medicine, EarlyView.
The molecular typing of esophageal cancer based on genome, transcriptome, proteome, and multi‐omics revealed various molecular features and provided potential targets for the precision therapy. Recent trials have shown that immunotherapy or molecular targeted therapy plus chemoradiotherapy can improve overall survival and progression‐free survival in ...
Guangkun Pei, Zhuoran Liang, Bianli Gu, Linlin Shi, Ze‐Xian Liu, Shegan Gao   +5 more
wiley   +1 more source