Results 111 to 120 of about 93,647 (322)
The Nasal Microbiome and Associations With Environmental Exposures and Respiratory Health
Allergy, EarlyView.This study evaluates the association of the nasal microbiome with air pollutants, meteorological conditions, and respiratory health in adolescents. Bacterial diversity is positively associated with hay fever and short‐term NO2 exposure, and negatively with temperature. A Moraxella‐dominated nasotype is linked to lower O3 exposure and higher temperature
Javier Perez‐Garcia +11 more
wiley +1 more source
Transcriptional dissection of melanoma identifies a high-risk subtype underlying TP53 family genes and epigenome deregulation [PDF]
, 2017 Brateil Badal +23 more
openalex +1 more source
The use of deidentified organ donor testes for research
Andrology, EarlyView.Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova +4 more
wiley +1 more source
Bifurcation in epigenetics: implications in development, proliferation and diseases
, 2014 Cells often exhibit different and stable phenotypes from the same DNA sequence. Robustness and plasticity of such cellular states are controlled by diverse transcriptional and epigenetic mechanisms, among them the modification of biochemical marks on ...
Jost, Daniel
core +1 more source
British Journal of Haematology, EarlyView.We show how the loss of activity of the translation initiation factor EIF5A2—either through gene hypermethylation or pharmacologic inhibition of its highly specific hypusine post‐translational modification—induces venetoclax sensitivity in acute myeloid leukaemia (AML) cells.
Eva Crespo‐García +5 more
wiley +1 more source
Frontiers in Oncology, 2013 It is well known that Neuroblastoma (NB) patients whose tumors have an undifferentiated histology and a transcriptome enriched in cell cycle genes have a worse prognosis.
Stanley eHe +3 more
doaj +1 more source
The biological embedding of early-life socioeconomic status and family adversity in children's genome-wide DNA methylation. [PDF]
, 2018 AimTo examine variation in child DNA methylation to assess its potential as a pathway for effects of childhood social adversity on health across the life course.Materials & methodsIn a diverse, prospective community sample of 178 kindergarten ...
Adler, Nancy E +8 more
core +1 more source
British Journal of Pharmacology, EarlyView.Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang +18 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2019 The development of the human cerebral cortex is a complex and dynamic process, in which neural stem cell proliferation, neuronal migration, and post-migratory neuronal organization need to occur in a well-organized fashion.
Elena Perenthaler +3 more
doaj +1 more source
Association of Arsenic Exposure with Whole Blood DNA Methylation: An Epigenome-Wide Study of Bangladeshi Adults [PDF]
, 2019 Kathryn Demanelis +16 more
openalex +1 more source