Results 111 to 120 of about 87,804 (313)
Marine-Derived Secondary Metabolites as Promising Epigenetic Bio-Compounds for Anticancer Therapy
Marine Drugs, 2020 Sessile organisms such as seaweeds, corals, and sponges continuously adapt to both abiotic and biotic components of the ecosystem. This extremely complex and dynamic process often results in different forms of competition to ensure the maintenance of an ...
Mariarosaria Conte +3 more
doaj +1 more source
Environmental and Molecular Mutagenesis, EarlyView.Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk +4 more
wiley +1 more source
Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain
Cell Reports, 2016 Organoids derived from human pluripotent stem cells recapitulate the early three-dimensional organization of the human brain, but whether they establish the epigenomic and transcriptional programs essential for brain development is unknown.
Chongyuan Luo +5 more
doaj +1 more source
Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner. [PDF]
, 2019 BackgroundRewriting of the epigenome has risen as a promising alternative to gene editing for precision medicine. In nature, epigenetic silencing can result in complete attenuation of target gene expression over multiple mitotic divisions.
Bates, Sofie L +8 more
core +2 more sources
Impact of Endocrine‐Disrupting Chemicals (EDCs) Used in the Food Industry on Endocrine Abnormalities
Food Safety and Health, EarlyView.This review was conducted to examine the relationship between hormone disruption and other endocrine abnormalities in the context of the constant consumption of genetically modified foods and overexposure to chemicals used directly and indirectly in the agrifood industry.
Perla D. Serrano‐López +3 more
wiley +1 more source
Cell Reports, 2021 Summary: Human induced pluripotent stem cells (hiPSCs) show variable differentiation potential due to their epigenomic heterogeneity, whose extent/attributes remain unclear, except for well-studied elements/chromosomes such as imprints and the X ...
Shihori Yokobayashi +10 more
doaj
A hitchhiker's guide to single‐cell epigenomics: Methods and applications for cancer research
International Journal of Cancer, EarlyView.Abstract Genetic mutations are well known to influence tumorigenesis, tumor progression, treatment response and relapse, but the role of epigenetic variation in cancer progression is still largely unexplored. The lack of epigenetic understanding in cancer evolution is in part due to the limited availability of methods to examine such a heterogeneous ...
Marta Moreno‐Gonzalez +2 more
wiley +1 more source
Insertion of short L1 sequences generates inter-strain histone acetylation differences in the mouse
Mobile DNABackground Gene expression divergence between populations and between individuals can emerge from genetic variations within the genes and/or in the cis regulatory elements.
Beverly Ann G. Boyboy, Kenji Ichiyanagi
doaj +1 more source
Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution
International Journal of Cancer, EarlyView.Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano +6 more
wiley +1 more source
ERRATUM: Acknowledgments Correction. Cell-Free miR-27a, a Potential Diagnostic and Prognostic Biomarker for Gastric Cancer [PDF]
Genomics & Informatics, 2015 Jong-Lyul Park +4 more
doaj +1 more source