Results 11 to 20 of about 21,621 (295)
Regenerating the epigenome [PDF]
EMBO reports, 2011 The ability of some organisms to regenerate parts of their body has fascinated scientists for decades. The process of regeneration depends on the potential of certain cells to proliferate and contribute to the formation of new tissue. Organisms have evolved two strategies by which to achieve this: the maintenance of adult stem cells and the induction ...
Juan Carlos Izpisua Belmonte +1 more
openaire +5 more sources
Spatial epigenome–transcriptome co-profiling of mammalian tissues
Nature, 2023 The authors present two technologies for spatially resolved, genome-wide, joint profiling of the epigenome and transcriptome by cosequencing chromatin accessibility and gene expression, or histone modifications and gene expression on the same tissue ...
Di Zhang +22 more
semanticscholar +1 more source
Drugging the epigenome in the age of precision medicine
Clinical Epigenetics, 2023 Background Modulating the epigenome has long been considered a potential opportunity for therapeutic intervention in numerous disease areas with several approved therapies marketed, primarily for cancer.
Taylor J. Feehley +4 more
semanticscholar +1 more source
Clinical application of liquid biopsy in cancer patients
BMC Cancer, 2022 Background This study was to determine the prevalence and clinical significance of clonal hematopoiesis (CH)-related variants, and somatic and germline mutations in cancer patients and healthy individuals.
Chieh-Min Chang +7 more
doaj +1 more source
Nature Genetics, 2023 Asymmetric segregation of parental histones H3 and H4 in MCM2-mutant embryonic stem cells impacts mitotic inheritance of histone modifications and genome regulation. MCM2-2A mutation perturbs exit from pluripotency and differentiation.
Alice Wenger +13 more
semanticscholar +1 more source
Therapeutic and immunomodulatory potential of pazopanib in malignant phyllodes tumor
npj Breast Cancer, 2022 Malignant phyllodes tumors (PT) are rare aggressive fibroepithelial neoplasms with high metastatic potential and lack effective therapy. We established a patient-derived xenograft (PDX) and cell line model (designated MPT-S1) of malignant PT which ...
Dave Yong Xiang Ng +20 more
doaj +1 more source
Cell-Free miR-27a, a Potential Diagnostic and Prognostic Biomarker for Gastric Cancer [PDF]
Genomics & Informatics, 2015 MicroRNAs (miRNAs) have been demonstrated to play an important role in carcinogenesis. Previous studies revealed that miRNAs are present in human plasma in a remarkably stable form that is protected from endogenous RNase activity.
Jong-Lyul Park +4 more
doaj +1 more source
Manipulation of Epigenome: Opportunities and Pitfalls in Fighting Autoimmune Diseases [PDF]
International Journal of Biomedicine, 2022 Many recent studies have focused on the manipulation of the epigenome to understand the mechanistic programming in health and some disease phenotypes.
Hassan Higazi +6 more
doaj +1 more source
Mutation profile of non-small cell lung cancer revealed by next generation sequencing
Respiratory Research, 2021 Background Precision therapy for lung cancer requires comprehensive genomic analyses. Specific effects of targeted therapies have been reported in Asia populations, including Taiwanese, but genomic studies have rarely been performed in these populations.
Ya-Sian Chang +7 more
doaj +1 more source
Toward the Development of Epigenome Editing-Based Therapeutics: Potentials and Challenges
International Journal of Molecular Sciences, 2023 The advancement in epigenetics research over the past several decades has led to the potential application of epigenome-editing technologies for the treatment of various diseases. In particular, epigenome editing is potentially useful in the treatment of
J. Ueda +2 more
semanticscholar +1 more source