Results 11 to 20 of about 93,647 (322)

Author Correction: Mapping histone modifications in low cell number and single cells using antibody-guided chromatin tagmentation (ACT-seq)

Nature Communications, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Benjamin Carter, Wai Lim Ku, Jee Youn Kang, Gangqing Hu, Jonathan Perrie, Qingsong Tang, Keji Zhao   +6 more
doaj   +1 more source

Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study

Arthritis Research & Therapy, 2022
Background Gout is a highly hereditary disease, but not all those carrying well-known risk variants have developing gout attack even in hyperuricemia status.
Ya-Sian Chang, Chien-Yu Lin, Ting-Yuan Liu, Chung-Ming Huang, Chin-Chun Chung, Yu-Chia Chen, Fuu-Jen Tsai, Jan-Gowth Chang, Shun-Jen Chang   +8 more
doaj   +1 more source

Multiregion sequencing of sarcomatoid renal cell carcinoma arising from autosomal dominant polycystic kidney disease

Molecular Genetics & Genomic Medicine, 2022
Background Autosomal dominant polycystic kidney disease (ADPKD) is an inherited cystic kidney disease associated with a spectrum of various renal and extrarenal manifestations, including increased risk of kidney cancers.
Elizabeth Lee, Peiyong Guan, Abner Herbert Lim, Jui Wan Loh, Grace Fangmin Tan, Tracy Loh, Dave Yong Xiang Ng, Jing Yi Lee, Shane Goh, Wei Liu, Cedric Chuan‐Young Ng, Bin Tean Teh, Jason Yongsheng Chan   +12 more
doaj   +1 more source

scPCOR-seq enables co-profiling of chromatin occupancy and RNAs in single cells

Communications Biology, 2022
scPCOR-seq is a single-cell sequencing technique that enables simultaneous profiling of genome-wide chromatin protein binding or histone modification marks and RNA expression in the same cell.
Lixia Pan, Wai Lim Ku, Qingsong Tang, Yaqiang Cao, Keji Zhao   +4 more
doaj   +1 more source

Hi-TrAC reveals division of labor of transcription factors in organizing chromatin loops

Nature Communications, 2022
It is currently not clear how architectural proteins orchestrate chromatin looping at different scales of genome organisation. Here the authors report Hi-TrAC as a proximity ligation-free method to profile genome-wide chromatin interactions at single ...
Shuai Liu, Yaqiang Cao, Kairong Cui, Qingsong Tang, Keji Zhao   +4 more
doaj   +1 more source

Exercise epigenetics and the foetal origins of disease [PDF]

, 2014
Exercise epigenetics is a nascent area of research with vast health implications (e.g., from the treatment of obesity-related diseases to beneficially decoupling epigenetic and chronological age).
Dale E, Thomas EW Chalk, William M Brown
core   +1 more source

Epigenetic Memories in Hematopoietic Stem and Progenitor Cells

Cells, 2022
The recent development of next-generation sequencing (NGS) technologies has contributed to research into various biological processes. These novel NGS technologies have revealed the involvement of epigenetic memories in trained immunity, which are ...
Kazumasa Aoyama, Naoki Itokawa, Motohiko Oshima, Atsushi Iwama   +3 more
doaj   +1 more source

melRNA-seq for Expression Analysis of SINE RNAs and Other Medium-Length Non-Coding RNAs

Mobile DNA, 2021
Background Small interspersed elements (SINEs) are transcribed by RNA polymerase III (Pol III) to produce RNAs typically 100–500 nucleotides in length.
Yoshinobu Mori, Kenji Ichiyanagi
doaj   +1 more source

Racial disparities in liver cancer: Evidence for a role of environmental contaminants and the epigenome

Frontiers in Oncology, 2022
Liver cancer incidence has tripled since the early 1980s, making this disease one of the fastest rising types of cancer and the third leading cause of cancer-related deaths worldwide.
Adriana C. Vidal, Cynthia A. Moylan, Julius Wilder, Delores J. Grant, Susan K. Murphy, Cathrine Hoyo   +5 more
doaj   +1 more source

The long-term impact of folic acid in pregnancy on offspring DNA methylation : follow-up of the Aberdeen folic acid supplementation trial (AFAST) [PDF]

, 2018
Funding This work was supported by the NIHR Bristol Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol.
Atkinson, Charlotte, Bhattacharya, Sohinee, Campbell, Doris, Gaunt, Tom, Hall, Marion, Herbert, Georgia, Kazmi, Nabila, McArdle, Wendy, Ness, Andy, Relton, Caroline L., Richmond, Rebecca C., Ring, Susan, Sharp, Gemma C., Smith, George Davey, Taylor, Caroline   +14 more
core   +3 more sources