Results 21 to 30 of about 87,804 (313)

The Epigenomics of Cancer [PDF]

Cell, 2007
Aberrant gene function and altered patterns of gene expression are key features of cancer. Growing evidence shows that acquired epigenetic abnormalities participate with genetic alterations to cause this dysregulation. Here, we review recent advances in understanding how epigenetic alterations participate in the earliest stages of neoplasia, including ...
Stephen B. Baylin, Peter A. Jones
openaire   +3 more sources

Rewriting the Epigenome [PDF]

Cell, 2012
The eukaryotic genome is packaged into a highly ordered chromatin structure, with specific domains regulating the transcription patterns of local genes. Hathaway et al. now present a breakthrough technique in the artificial induction of chromatin marks and use this experimental model to test the properties of an induced heterochromatic domain.
Oliver J. Rando, Benjamin R. Carone
openaire   +3 more sources

Exercise epigenetics and the foetal origins of disease [PDF]

, 2014
Exercise epigenetics is a nascent area of research with vast health implications (e.g., from the treatment of obesity-related diseases to beneficially decoupling epigenetic and chronological age).
Dale E, Thomas EW Chalk, William M Brown
core   +1 more source

Author Correction: Mapping histone modifications in low cell number and single cells using antibody-guided chromatin tagmentation (ACT-seq)

Nature Communications, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Benjamin Carter, Wai Lim Ku, Jee Youn Kang, Gangqing Hu, Jonathan Perrie, Qingsong Tang, Keji Zhao   +6 more
doaj   +1 more source

Manipulation of Epigenome: Opportunities and Pitfalls in Fighting Autoimmune Diseases [PDF]

International Journal of Biomedicine, 2022
Many recent studies have focused on the manipulation of the epigenome to understand the mechanistic programming in health and some disease phenotypes.
Hassan Higazi, Faheem Ahmed Khan, Sara Ali, Salma Mohamed, Nuruliarizki Shinta Pandupuspitasari, Ashraf S. Yousif, Praveen Kumar Kandakurti   +6 more
doaj   +1 more source

A companion to the preclinical common data elements for genomics, transcriptomics, and epigenomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint translational TASK force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines. The aim of the CDEs is to improve the standardization of experimental designs across a range of epilepsy ...
Erwin A. van Vliet, Michael S. Hildebrand, James D. Mills, Gary P. Brennan, Tore Eid, Susan A. Masino, Vicky Whittemore, Laura Bindila, Kevin K. Wang, Manisha Patel, Piero Perucca, Christopher A. Reid   +11 more
wiley   +1 more source

Long Noncoding RNA NTT Context-Dependently Regulates MYB by Interacting With Activated Complex in Hepatocellular Carcinoma Cells

Frontiers in Oncology, 2021
BackgroundLong noncoding RNA (lncRNA) mediates the pathogenesis of various diseases, including cancer and cardiovascular, infectious, and metabolic diseases.
Ya-Sian Chang, Ya-Sian Chang, Ya-Sian Chang, Ya-Ting Lee, Ju-Chen Yen, Yuli C. Chang, Li-Li Lin, Wen-Ling Chan, Wei-Chiao Chang, Shyr-Yi Lin, Shyr-Yi Lin, Jan-Gowth Chang, Jan-Gowth Chang, Jan-Gowth Chang   +13 more
doaj   +1 more source

Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome. [PDF]

, 2011
Vertebrate embryos are derived from a transitory pool of pluripotent cells. By the process of embryonic induction, these precursor cells are assigned to specific fates and differentiation programs.
Arteaga-Salas, Jose M., David, Robert, Imhof, Axel, Mentele, Edith, Nicetto, Dario, Rupp, Ralph A. W., Schneider, Tobias D.   +6 more
core   +3 more sources

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

melRNA-seq for Expression Analysis of SINE RNAs and Other Medium-Length Non-Coding RNAs

Mobile DNA, 2021
Background Small interspersed elements (SINEs) are transcribed by RNA polymerase III (Pol III) to produce RNAs typically 100–500 nucleotides in length.
Yoshinobu Mori, Kenji Ichiyanagi
doaj   +1 more source