Results 21 to 30 of about 21,621 (295)

Concurrent mapping of multiple epigenetic marks and co-occupancy using ACT2-seq

Cell & Bioscience, 2021
Background Genome-wide profiling of epigenetic marks is a core technology in molecular genetics. Co-occupancy of different epigenetic marks or protein factors at the same genomic locations must often be inferred from multiple independently collected data
Benjamin Carter, Wai Lim Ku, Joe Pelt, Keji Zhao   +3 more
doaj   +1 more source

WashU Epigenome Browser update 2022

Nucleic Acids Res., 2022
WashU Epigenome Browser (https://epigenomegateway.wustl.edu/browser/) is a web-based genomic data exploration tool that provides visualization, integration, and analysis of epigenomic datasets.
Daofeng Li, Deepak Purushotham, J. Harrison, Silas Hsu, Xiaoyu Zhuo, Changxu Fan, Shan Liu, Vincent Xu, Samuel Chen, Jason Xu, Shinyi Ouyang, Angela S. Wu, Ting Wang   +12 more
semanticscholar   +1 more source

Infection of Brain Organoids and 2D Cortical Neurons with SARS-CoV-2 Pseudovirus

Viruses, 2020
Since the global outbreak of SARS-CoV-2 (COVID-19), infections of diverse human organs along with multiple symptoms continue to be reported. However, the susceptibility of the brain to SARS-CoV-2, and the mechanisms underlying neurological infection are ...
Sang Ah Yi, Ki Hong Nam, Jihye Yun, Dongmin Gim, Daeho Joe, Yong Ho Kim, Han-Joo Kim, Jeung-Whan Han, Jaecheol Lee   +8 more
doaj   +1 more source

A companion to the preclinical common data elements for genomics, transcriptomics, and epigenomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint translational TASK force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines. The aim of the CDEs is to improve the standardization of experimental designs across a range of epilepsy ...
Erwin A. van Vliet, Michael S. Hildebrand, James D. Mills, Gary P. Brennan, Tore Eid, Susan A. Masino, Vicky Whittemore, Laura Bindila, Kevin K. Wang, Manisha Patel, Piero Perucca, Christopher A. Reid   +11 more
wiley   +1 more source

The EWAS Catalog: a database of epigenome-wide association studies.

Wellcome Open Research, 2021
Epigenome-wide association studies (EWAS) seek to quantify associations between traits/exposures and DNA methylation measured at thousands or millions of CpG sites across the genome.
T. Battram, P. Yousefi, G. Crawford, C. Prince, Mahsa Sheikhali Babei, G. Sharp, C. Hatcher, María Jesús Vega-Salas, Sahar Khodabakhsh, O. Whitehurst, Ryan J. Langdon, Luke Mahoney, H. Elliott, G. Mancano, Matthew A. Lee, Sarah H. Watkins, A. Lay, G. Hemani, Tom R. Gaunt, C. Relton, James R. Staley, M. Suderman   +21 more
semanticscholar   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Multiregion sequencing of sarcomatoid renal cell carcinoma arising from autosomal dominant polycystic kidney disease

Molecular Genetics & Genomic Medicine, 2022
Background Autosomal dominant polycystic kidney disease (ADPKD) is an inherited cystic kidney disease associated with a spectrum of various renal and extrarenal manifestations, including increased risk of kidney cancers.
Elizabeth Lee, Peiyong Guan, Abner Herbert Lim, Jui Wan Loh, Grace Fangmin Tan, Tracy Loh, Dave Yong Xiang Ng, Jing Yi Lee, Shane Goh, Wei Liu, Cedric Chuan‐Young Ng, Bin Tean Teh, Jason Yongsheng Chan   +12 more
doaj   +1 more source

Hi-TrAC reveals division of labor of transcription factors in organizing chromatin loops

Nature Communications, 2022
It is currently not clear how architectural proteins orchestrate chromatin looping at different scales of genome organisation. Here the authors report Hi-TrAC as a proximity ligation-free method to profile genome-wide chromatin interactions at single ...
Shuai Liu, Yaqiang Cao, Kairong Cui, Qingsong Tang, Keji Zhao   +4 more
doaj   +1 more source

scPCOR-seq enables co-profiling of chromatin occupancy and RNAs in single cells

Communications Biology, 2022
scPCOR-seq is a single-cell sequencing technique that enables simultaneous profiling of genome-wide chromatin protein binding or histone modification marks and RNA expression in the same cell.
Lixia Pan, Wai Lim Ku, Qingsong Tang, Yaqiang Cao, Keji Zhao   +4 more
doaj   +1 more source

Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study

Arthritis Research & Therapy, 2022
Background Gout is a highly hereditary disease, but not all those carrying well-known risk variants have developing gout attack even in hyperuricemia status.
Ya-Sian Chang, Chien-Yu Lin, Ting-Yuan Liu, Chung-Ming Huang, Chin-Chun Chung, Yu-Chia Chen, Fuu-Jen Tsai, Jan-Gowth Chang, Shun-Jen Chang   +8 more
doaj   +1 more source