Results 31 to 40 of about 21,621 (295)
Nature Communications, 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Benjamin Carter +6 more
doaj +1 more source
melRNA-seq for Expression Analysis of SINE RNAs and Other Medium-Length Non-Coding RNAs
Mobile DNA, 2021 Background Small interspersed elements (SINEs) are transcribed by RNA polymerase III (Pol III) to produce RNAs typically 100–500 nucleotides in length.
Yoshinobu Mori, Kenji Ichiyanagi
doaj +1 more source
Epigenome-wide association studies: current knowledge, strategies and recommendations
Clinical Epigenetics, 2021 The aetiology and pathophysiology of complex diseases are driven by the interaction between genetic and environmental factors. The variability in risk and outcomes in these diseases are incompletely explained by genetics or environmental risk factors ...
M. Campagna +7 more
semanticscholar +1 more source
Nature Communications, 2019 The authors introduce ACT-seq: a Tn5-based method for rapidly profiling epigenetic marks in bulk-cell and single-cell samples. ACT-seq avoids many laborious or time-consuming steps required for similar techniques including chromatin fragmentation and end
Benjamin Carter +6 more
doaj +1 more source
Translational Psychiatry, 2021 Childhood maltreatment is a major risk factor for chronic and severe mental and physical health problems across the lifespan. Increasing evidence supports the hypothesis that maltreatment is associated with epigenetic changes that may subsequently serve ...
S. Parade +5 more
semanticscholar +1 more source
Multiplex Epigenome Editing of MECP2 to Rescue Rett Syndrome Neurons
bioRxiv, 2022 Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by loss-of-function heterozygous mutations of Methyl CpG-binding Protein 2 (MECP2) on the X chromosome in girls.
Junming Qian +9 more
semanticscholar +1 more source
The Epigenome in Neurodevelopmental Disorders [PDF]
Frontiers in Neuroscience, 2021 Neurodevelopmental diseases (NDDs), such as autism spectrum disorders, epilepsy, and schizophrenia, are characterized by diverse facets of neurological and psychiatric symptoms, differing in etiology, onset and severity. Such symptoms include mental delay, cognitive and language impairments, or restrictions to adaptive and social behavior. Nevertheless,
Julia Reichard +3 more
openaire +5 more sources
Nature Reviews Cancer, 2020 Epigenetic regulation is critical to physiological control of development, cell fate, cell proliferation, genomic integrity, and fundamentally, transcriptional regulation. This epigenetic control occurs at multiple levels including through DNA methylation, histone modification, nucleosome remodeling, and modulation of the three-dimensional chromatin ...
Jamie S.E. Yu +8 more
openaire +4 more sources
Molecular Ecology Resources, EarlyView., 2023 Abstract Captive rearing in salmon hatcheries can have considerable impacts on both fish phenotype and fitness within a single generation, even in the absence of genetic change. Evidence for hatchery‐induced changes in DNA methylation is becoming abundant, though questions remain on the sex‐specificity of these effects, their persistence until spawning
Clare J. Venney +6 more
wiley +1 more source
Epigenetic alterations in TRAMP mice: epigenome DNA methylation profiling using MeDIP-seq
Cell & Bioscience, 2018 Purpose We investigated the genomic DNA methylation profile of prostate cancer in transgenic adenocarcinoma of the mouse prostate (TRAMP) cancer model and to analyze the crosstalk among targeted genes and the related functional pathways. Methods Prostate
Wenji Li +11 more
doaj +1 more source