Results 31 to 40 of about 87,804 (313)

The Epigenome in Neurodevelopmental Disorders [PDF]

Frontiers in Neuroscience, 2021
Neurodevelopmental diseases (NDDs), such as autism spectrum disorders, epilepsy, and schizophrenia, are characterized by diverse facets of neurological and psychiatric symptoms, differing in etiology, onset and severity. Such symptoms include mental delay, cognitive and language impairments, or restrictions to adaptive and social behavior. Nevertheless,
Julia Reichard, Julia Reichard, Geraldine Zimmer-Bensch, Geraldine Zimmer-Bensch   +3 more
openaire   +5 more sources

Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis [PDF]

, 2015
Interest in the potential of DNA methylation in peripheral blood as a biomarker of cancer risk is increasing. We aimed to assess whether epigenome-wide DNA methylation measured in peripheral blood samples obtained before onset of the disease is ...
Agnoli, C, Ashworth, A, Baglietto, L, Chadeau, M, Curry, E, Flanagan, JM, Flower, K, Frasca, G, Garcia-Closas, M, Jones, M, Krogh, V, Lund, E, Masala, G, Mattiello, A, Orr, N, Palli, D, Panico, S, Polidoro, S, Sacerdote, C, Sandanger, T, Severi, G, Swerdlow, A, Tomczyk, K, Tumino, R, van veldhoven, K, vineis, P   +25 more
core   +5 more sources

Mapping histone modifications in low cell number and single cells using antibody-guided chromatin tagmentation (ACT-seq)

Nature Communications, 2019
The authors introduce ACT-seq: a Tn5-based method for rapidly profiling epigenetic marks in bulk-cell and single-cell samples. ACT-seq avoids many laborious or time-consuming steps required for similar techniques including chromatin fragmentation and end
Benjamin Carter, Wai Lim Ku, Jee Youn Kang, Gangqing Hu, Jonathan Perrie, Qingsong Tang, Keji Zhao   +6 more
doaj   +1 more source

The importance of detailed epigenomic profiling of different cell types within organs. [PDF]

, 2016
The human body consists of hundreds of kinds of cells specified from a single genome overlaid with cell type-specific epigenetic information. Comprehensively profiling the body's distinct epigenetic landscapes will allow researchers to verify cell types ...
Borok, Zea, Laird-Offringa, Ite A, Marconett, Crystal N, Stueve, Theresa Ryan, Zhou, Beiyun   +4 more
core   +1 more source

The epigenomics of sarcoma

Nature Reviews Cancer, 2020
Epigenetic regulation is critical to physiological control of development, cell fate, cell proliferation, genomic integrity, and fundamentally, transcriptional regulation. This epigenetic control occurs at multiple levels including through DNA methylation, histone modification, nucleosome remodeling, and modulation of the three-dimensional chromatin ...
Jamie S.E. Yu, William D. Tap, Andrew M. Intlekofer, Torsten O. Nielsen, Marc Ladanyi, Kevin B. Jones, C. David Allis, Benjamin A. Nacev, Benjamin A. Nacev   +8 more
openaire   +4 more sources

Plants regenerated from tissue culture contain stable epigenome changes in rice. [PDF]

, 2013
Most transgenic crops are produced through tissue culture. The impact of utilizing such methods on the plant epigenome is poorly understood. Here we generated whole-genome, single-nucleotide resolution maps of DNA methylation in several regenerated rice ...
Bellizzi, Maria, Ding, Bo, Feng, Suhua, Jacobsen, Steven E, Meyers, Blake C, Pellegrini, Matteo, Simon, Stacey A, Stroud, Hume, Wang, Guo-Liang   +8 more
core   +2 more sources

Epigenetic alterations in TRAMP mice: epigenome DNA methylation profiling using MeDIP-seq

Cell & Bioscience, 2018
Purpose We investigated the genomic DNA methylation profile of prostate cancer in transgenic adenocarcinoma of the mouse prostate (TRAMP) cancer model and to analyze the crosstalk among targeted genes and the related functional pathways. Methods Prostate
Wenji Li, Ying Huang, Davit Sargsyan, Tin Oo Khor, Yue Guo, Limin Shu, Anne Yuqing Yang, Chengyue Zhang, Ximena Paredes-Gonzalez, Michael Verzi, Ronald P. Hart, Ah-Ng Kong   +11 more
doaj   +1 more source

Transcriptional repression shapes the identity and function of tissue macrophages

FEBS Open Bio, 2021
The changing extra‐ and intracellular microenvironment calls for rapid cell fate decisions that are precisely and primarily regulated at the transcriptional level.
Krisztian Bene, Laszlo Halasz, Laszlo Nagy   +2 more
doaj   +1 more source

Epigenomics of macrophages [PDF]

Immunological Reviews, 2014
SummaryMacrophages play essential roles in tissue homeostasis, pathogen elimination, and tissue repair. A defining characteristic of these cells is their ability to efficiently adapt to a variety of abruptly changing and complex environments. This ability is intrinsically linked to a capacity to quickly alter their transcriptome, and this is tightly ...
Christopher K. Glass, David Gosselin
openaire   +2 more sources

Locus-specific hypomethylation of the mouse IAP retrotransposon is associated with transcription factor-binding sites

Mobile DNA, 2017
Background Intracisternal A particle (IAP) is one of the most transpositionally active retrotransposons in the mouse genome, but its expression varies between cell types. This variation is believed to arise from differences in the epigenetic state (e.g.,
Ken-ichi Shimosuga, Kei Fukuda, Hiroyuki Sasaki, Kenji Ichiyanagi   +3 more
doaj   +1 more source