Results 41 to 50 of about 21,621 (295)
Biomolecular Concepts, 2022 One pillar of the predictive, preventive, and personalized medicine framework strategies is the female health. The evaluation of women’s lifestyle and dietary habits in context with genetic and modifiable risk factors may reflect the prevention of ...
Holubekova Veronika +10 more
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Epigenomics of macrophages [PDF]
Immunological Reviews, 2014 SummaryMacrophages play essential roles in tissue homeostasis, pathogen elimination, and tissue repair. A defining characteristic of these cells is their ability to efficiently adapt to a variety of abruptly changing and complex environments. This ability is intrinsically linked to a capacity to quickly alter their transcriptome, and this is tightly ...
Christopher K. Glass, David Gosselin
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Mobile DNA, 2017 Background Intracisternal A particle (IAP) is one of the most transpositionally active retrotransposons in the mouse genome, but its expression varies between cell types. This variation is believed to arise from differences in the epigenetic state (e.g.,
Ken-ichi Shimosuga +3 more
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The Toolbox for Untangling Chromosome Architecture in Immune Cells
Frontiers in Immunology, 2021 The code of life is not only encrypted in the sequence of DNA but also in the way it is organized into chromosomes. Chromosome architecture is gradually being recognized as an important player in regulating cell activities (e.g., controlling ...
Shuai Liu, Keji Zhao
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UNADON: Transformer-based model to predict genome-wide chromosome spatial position [PDF]
arXiv, 2023 The spatial positioning of chromosomes relative to functional nuclear bodies is intertwined with genome functions such as transcription. However, the sequence patterns and epigenomic features that collectively influence chromatin spatial positioning in a genome-wide manner are not well understood.
arxiv
Nature Biotechnology, 2015 Technologies that enable targeted manipulation of epigenetic marks could be used to precisely control cell phenotype or interrogate the relationship between the epigenome and transcriptional control.
Isaac B. Hilton +6 more
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The allure of the epigenome [PDF]
Genome Biology, 2012 The Oxford English Dictionary dates the word 'genome' to 1926 but has not yet seen fit to include the term 'epigenome' in its illustrious pages (where it would reside handsomely between 'epigenist' and 'epigenous'). This differential treatment reflects a state of affairs in which the epigenome has yet to infiltrate the popular imagination, but belies ...
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Nature Reviews Immunology, 2021 A new study in Cell provides a single-cell map of the epigenetic and transcriptomic landscape in response to influenza vaccination, revealing persistent epigenomic remodelling in myeloid cells and the antiviral effects of adjuvant.
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Kernel-Based Testing for Single-Cell Differential Analysis [PDF]
arXiv, 2023 Single-cell technologies offer insights into molecular feature distributions, but comparing them poses challenges. We propose a kernel-testing framework for non-linear cell-wise distribution comparison, analyzing gene expression and epigenomic modifications.
arxiv
eLife, 2022 A new approach helps to assess the impact of accelerated epigenetic aging on the risk of cancer.
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