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The allure of the epigenome [PDF]
Genome Biology, 2012 The Oxford English Dictionary dates the word 'genome' to 1926 but has not yet seen fit to include the term 'epigenome' in its illustrious pages (where it would reside handsomely between 'epigenist' and 'epigenous'). This differential treatment reflects a state of affairs in which the epigenome has yet to infiltrate the popular imagination, but belies ...
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Nature Reviews Immunology, 2021 A new study in Cell provides a single-cell map of the epigenetic and transcriptomic landscape in response to influenza vaccination, revealing persistent epigenomic remodelling in myeloid cells and the antiviral effects of adjuvant.
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The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936 [PDF]
, 2015 Background: The DNA methylation-based 'epigenetic clock' correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the epigenetic clock and
Corley, Janie +17 more
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eLife, 2022 A new approach helps to assess the impact of accelerated epigenetic aging on the risk of cancer.
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dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression. [PDF]
, 2017 Distinct epigenomic profiles of histone marks have been associated with gene expression, but questions regarding the causal relationship remain. Here we investigated the activity of a broad collection of genomically targeted epigenetic regulators that ...
Farnham, Peggy J +8 more
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Biomolecular Concepts, 2022 One pillar of the predictive, preventive, and personalized medicine framework strategies is the female health. The evaluation of women’s lifestyle and dietary habits in context with genetic and modifiable risk factors may reflect the prevention of ...
Holubekova Veronika +10 more
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Molecular Cell, 2016 During aging, the mechanisms that normally maintain health and stress resistance strikingly decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this decline occurs is unknown. Changes in transcriptional networks and chromatin state lie at the heart of age-dependent decline.
Lauren N. Booth, Anne Brunet
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The Toolbox for Untangling Chromosome Architecture in Immune Cells
Frontiers in Immunology, 2021 The code of life is not only encrypted in the sequence of DNA but also in the way it is organized into chromosomes. Chromosome architecture is gradually being recognized as an important player in regulating cell activities (e.g., controlling ...
Shuai Liu, Keji Zhao
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The Epigenome in Atherosclerosis [PDF]
, 2020 AbstractEmerging evidence suggests the growing importance of “nongenetic factors” in the pathogenesis of atherosclerotic vascular disease. Indeed, the inherited genome determines only part of the risk profile as genomic approaches do not take into account additional layers of biological regulation by “epi”-genetic changes.
Francesco Paneni, Sarah Costantino
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Selection for improved energy use efficiency and drought tolerance in canola results in distinct transcriptome and epigenome changes [PDF]
, 2015 To increase both the yield potential and stability of crops, integrated breeding strategies are used that have mostly a direct genetic basis, but the utility of epigenetics to improve complex traits is unclear. A better understanding of the status of the
Byzova, Marina +13 more
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