Results 51 to 60 of about 87,804 (313)
The long-term impact of folic acid in pregnancy on offspring DNA methylation : follow-up of the Aberdeen folic acid supplementation trial (AFAST) [PDF]
, 2018 Funding This work was supported by the NIHR Bristol Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol.
Atkinson, Charlotte +14 more
core +3 more sources
Current Opinion in Nephrology and Hypertension, 2020 Epigenetic modifications are reversible changes to a cell's DNA or histones that alter gene expression but not DNA sequence. The present review will explore epigenomic profiling and bioinformatics techniques for the study of kidney development and disease.Reversible DNA and histone modifications influence chromatin accessibility and can be measured by ...
Nicolas Ledru +2 more
openaire +3 more sources
Epigenomics of Hypertension [PDF]
Seminars in Nephrology, 2013 Multiple genes and pathways are involved in the pathogenesis of hypertension. Epigenomic studies of hypertension are beginning to emerge and hold great promise of providing novel insights into the mechanisms underlying hypertension. Epigenetic marks or mediators including DNA methylation, histone modifications, and noncoding RNA can be studied at a ...
Theodore A. Kotchen +4 more
openaire +3 more sources
Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs [PDF]
, 2016 BACKGROUND: A key focus in cancer research is the discovery of biomarkers that accurately diagnose early lesions in non-invasive tissues. Several studies have identified malignancy-associated DNA methylation changes in blood, yet no general cancer ...
Bell, CG +7 more
core +10 more sources
The Unicellular State as a Point Source in a Quantum Biological System. [PDF]
, 2016 A point source is the central and most important point or place for any group of cohering phenomena. Evolutionary development presumes that biological processes are sequentially linked, but neither directed from, nor centralized within, any specific ...
Miller, William B, Torday, John S
core +3 more sources
CTCF and cellular heterogeneity
Cell & Bioscience, 2019 Cellular heterogeneity, which was initially defined for tumor cells, is a fundamental property of all cellular systems, ranging from genetic diversity to cell-to-cell variation driven by stochastic molecular interactions involved all cellular processes ...
Gang Ren, Keji Zhao
doaj +1 more source
Frontiers in Oncology, 2022 Liver cancer incidence has tripled since the early 1980s, making this disease one of the fastest rising types of cancer and the third leading cause of cancer-related deaths worldwide.
Adriana C. Vidal +5 more
doaj +1 more source
Epigenetic Biomarkers for Environmental Exposures and Personalized Breast Cancer Prevention. [PDF]
, 2020 Environmental and lifestyle factors are believed to account for >80% of breast cancers; however, it is not well understood how and when these factors affect risk and which exposed individuals will actually develop the disease.
Park, Hannah Lui
core +1 more source
A unique chromatin profile defines adaptive genomic regions in a fungal plant pathogen
eLife, 2020 Genomes store information at scales beyond the linear nucleotide sequence, which impacts genome function at the level of an individual, while influences on populations and long-term genome function remains unclear.
David E Cook +4 more
doaj +1 more source
Maternal obesity blunts antimicrobial responses in fetal monocytes
eLife, 2023 Maternal pre-pregnancy (pregravid) obesity is associated with adverse outcomes for both mother and offspring. Amongst the complications for the offspring is increased susceptibility and severity of neonatal infections necessitating admission to the ...
Suhas Sureshchandra +6 more
doaj +1 more source