Results 71 to 80 of about 87,804 (313)

NRSF/REST-Mediated Epigenomic Regulation in the Heart: Transcriptional Control of Natriuretic Peptides and Beyond

Biology, 2022
Reactivation of fetal cardiac genes, including those encoding atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), is a key feature of pathological cardiac remodeling and heart failure.
Hideaki Inazumi, Koichiro Kuwahara
doaj   +1 more source

Vitamin D and the epigenome [PDF]

Frontiers in Physiology, 2014
Epigenetic mechanisms play a crucial role in regulating gene expression. The main mechanisms involve methylation of DNA and covalent modifications of histones by methylation, acetylation, phosphorylation, or ubiquitination. The complex interplay of different epigenetic mechanisms is mediated by enzymes acting in the nucleus.
Irfete S. Fetahu, E. Kállay, Julia Höbaus   +2 more
openaire   +4 more sources

The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription

Advanced Science, EarlyView.
ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma, Yingyi Zhang, Weijie Yang, Xiaomei Tong, Siya Liu, Yan Zhou, Mengjia Qiu, Huifang Jiang, Zhanhong Hu, Peipei Ren, Yan Rong, Mengru Lai, Jiamin Jin, Fei Huang, Liujian Ouyang, Feng Zhou, Heng‐Yu Fan, Yin‐Li Zhang, Songying Zhang   +18 more
wiley   +1 more source

Epigenetic Response of Yarrowia lipolytica to Stress: Tracking Methylation Level and Search for Methylation Patterns via Whole-Genome Sequencing

Microorganisms, 2021
DNA methylation is a common, but not universal, epigenetic modification that plays an important role in multiple cellular processes. While definitely settled for numerous plant, mammalian, and bacterial species, the genome methylation in different fungal
Monika Kubiak-Szymendera, Leszek P. Pryszcz, Wojciech Białas, Ewelina Celińska   +3 more
doaj   +1 more source

Maternal corticotropin-releasing hormone is associated with LEP DNA methylation at birth and in childhood: an epigenome-wide study in Project Viva [PDF]

, 2018
BackgroundCorticotropin-releasing hormone (CRH) plays a central role in regulating the secretion of cortisol which controls a wide range of biological processes. Fetuses overexposed to cortisol have increased risks of disease in later life.
A Cardenas, A Crudo, A Gavrila, Andrea A. Baccarelli, Andres Cardenas, Augusto A. Litonjua, C Lesseur, C Newton-Cheh, CA Sandman, CA Sandman, CE Boeke, CS Mantzoros, CV Breton, DA Kertes, Dawn L. DeMeo, DM O’Connor, E Baibazarova, E Marinoni, E Oken, E Oken, E Salvi, Emily Oken, ER Gibney, FI Milagro, Fu-Ying Tian, H Masuzaki, I Melzner, IC McMillen, Janet W. Rich-Edwards, JD Swinny, JJ Bonfiglio, JM Sheen, JT Smith, JW Rich-Edwards, K Barber, K Boekelheide, L Bouchard, LE Reinius, M Graff, M Urbanek, Mao-Meng Tiao, Marie-France Hivert, Matthew W. Gillman, MC García-Cardona, MC Sugden, MH Fasting, MW Gillman, MW Logue, N Alexander, N Sonenberg, ND Saenen, NJ Westphal, PD Wadhwa, PJ Trainer, R Kadakia, RL Emanuel, RS Ahima, RX Ren, S Pauwels, S Ramchandani, SA Obermann-Borst, Sheryl L. Rifas-Shiman, SJ McClennen, SJ McClennen, SY Moon, TA Dardeno, TC Martin, TJ Peters, VG Moisiadis, Y Chen, YC Chen, YD Salinas, Zari Dastani   +72 more
core   +1 more source

Environmental Exposures during Puberty: Window of Breast Cancer Risk and Epigenetic Damage. [PDF]

, 2020
During puberty, a woman's breasts are vulnerable to environmental damage ("window of vulnerability"). Early exposure to environmental carcinogens, endocrine disruptors, and unhealthy foods (refined sugar, processed fats, food additives) are hypothesized ...
Aljaber, Dana, Au, Dawn, Benmarhnia, Tarik, Cardiff, Robert D, Chavez, Tanya, Dietze, Eric C, Doan, Stacey, Jankowska, Marta M, Jones, Veronica, McCune, Jeannine S, Natarajan, Rama, Nunez, Alan, Resto, Cristal, Sanchez, Angelica, Seewaldt, Victoria L, Serrano, Mayra, Sistrunk, Christopher, Thai, Christine, Tomsic, Jerneja, Yang, Jiue-An   +19 more
core   +1 more source

Accounting for ALA Natural Mutations Enhances the Efficiency of Graphene Oxide Nanopriming in Bar‐Modified Arabidopsis

Advanced Science, EarlyView.
Nanopriming enhances plant resilience to environmental challenges; however, its effectiveness across diverse genetic backgrounds, including genetic modifications and natural variations, remains uncertain. These findings demonstrate that nanopriming improves efficacy when natural genetic variations are considered, particularly in genetically modified ...
Yining Wu, Rui Sun, Yueting Cui, Jun Qiao, Chengdong Zhang   +4 more
wiley   +1 more source

Histone variant H3.3 and its future prospects in cancer clinic

Journal of Radiation and Cancer Research, 2017
Histone variant, H3.3 has been a continuous subject of interest in the field of chromatin studies due to its two distinguishing features. First, its incorporation into chromatin is replication-independent, unlike the replication-coupled deposition of its
Divya Reddy, Sanjay Gupta
doaj   +1 more source

Restructuring of Lamina-Associated Domains in Senescence and Cancer

Cells, 2022
Induction of cellular senescence or cancer is associated with a reshaping of the nuclear envelope and a broad reorganization of heterochromatin. At the periphery of mammalian nuclei, heterochromatin is stabilized at the nuclear lamina via lamina ...
Aurélie Bellanger, Julia Madsen-Østerbye, Natalia M. Galigniana, Philippe Collas   +3 more
doaj   +1 more source

Maternal nutritional status, C1 metabolism and offspring DNA methylation: a review of current evidence in human subjects. [PDF]

, 2011
: Evidence is growing for the long-term effects of environmental factors during early-life on later disease susceptibility. It is believed that epigenetic mechanisms (changes in gene function not mediated by DNA sequence alteration), particularly DNA ...
Cox, SE, Dominguez-Salas, P, Hennig, BJ, Moore, SE, Prentice, AM   +4 more
core   +4 more sources