Results 81 to 90 of about 87,804 (313)

Gastrula‐Premarked Posterior Enhancer Primes Posterior Tissue Development Through Cross‐Talk with TGF‐β Signaling Pathway

Advanced Science, EarlyView.
A gastrula‐premarked enhancer within the first intron of Cdx2 governs posterior embryonic development via both regulating Cdx2 expression in cis and coordinating TGF‐β signaling in trans to ensure proper posterior body development. Functional rescue in gastruloids reveals a Cdx2‐independent pathway, highlighting p‐Enh‐eRNA as key epigenetic ...
Yingying Chen, Fengxiang Tan, Qing Fang, Lin Zhang, Jiaoyang Liao, Penglei Shen, Yun Qian, Mingzhu Wen, Rui Song, Yonggao Fu, He Jax Xu, Ran Wang, Cheng Li, Zhen Shao, Jinsong Li, Naihe Jing, Xianfa Yang   +16 more
wiley   +1 more source

The Epigenomics of Pituitary Adenoma

Frontiers in Endocrinology, 2019
Background: The vast majority of pituitary tumors are benign and behave accordingly; however, a fraction are invasive and are more aggressive, with a very small fraction being frankly malignant.
Blake M. Hauser, Ashley Lau, Saksham Gupta, Wenya Linda Bi, Ian F. Dunn   +4 more
doaj   +1 more source

PFKM‐Driven Lactate Overproduction Promotes Atrial Fibrillation via Triggering Cardiac Fibroblasts Histone Lactylation

Advanced Science, EarlyView.
The upregulation of PFKM activates glycolysis, thereby enhancing lactate production in atrial tissue. Atrial lactate accumulation promotes global lactylation and H3K18 lactylation in atrial fibroblasts. P300‐mediated H3K18 lactylation up‐regulates TGF‐β1 transcription, leading to fibroblast activation and thereby contributing to atrial fibrosis.
Ning Fang, Ning Zhang, Xiaohui Jiang, Sen Yan, Zhiqi Wang, Qianhui Gao, Mingcheng Xu, Lin Mu, Xiaoming Li, Jiuling Chen, Song Zhang, Yu Duan, Fengxiang Yun, Luyifei Li, Yun Zhang, Yongtai Gong   +15 more
wiley   +1 more source

Molecular characterization of colorectal cancer using whole‐exome sequencing in a Taiwanese population

Cancer Medicine, 2019
Next‐generation sequencing (NGS) technology is currently used to establish mutational profiles in many heterogeneous diseases. The aim of this study was to evaluate the mutational spectrum in Taiwanese patients with colorectal cancer (CRC) to help ...
Ya‐Sian Chang, Chien‐Chin Lee, Tao‐Wei Ke, Chieh‐Min Chang, Dy‐San Chao, Hsi‐Yuan Huang, Jan‐Gowth Chang   +6 more
doaj   +1 more source

Crop improvement using life cycle datasets acquired under field conditions

Frontiers in Plant Science, 2015
Crops are exposed to various environmental stresses in the field throughout their life cycle. Modern plant science has provided remarkable insights into the molecular networks of plant stress responses in laboratory conditions, but the responses of ...
Keiichi eMochida, Keiichi eMochida, Daisuke eSaisho, Takashi eHirayama   +3 more
doaj   +1 more source

DNA methylation profiles unique to Kalahari KhoeSan individuals

Epigenetics, 2021
Genomes of KhoeSan individuals of the Kalahari Desert provide the greatest understanding of single nucleotide diversity in the human genome. Compared with individuals in industrialized environments, the KhoeSan have a unique foraging and hunting ...
Alexander Goncearenco, Brenna A. LaBarre, Hanna M. Petrykowska, Weerachai Jaratlerdsiri, M. S. Riana Bornman, Stephen D. Turner, Vanessa M. Hayes, Laura Elnitski   +7 more
doaj   +1 more source

Global Reprogramming of Apoptosis-Related Genes during Brain Development

Cells, 2021
To enable long-term survival, mammalian adult neurons exhibit unique apoptosis competence. Questions remain as to whether and how neurons globally reprogram the expression of apoptotic genes during development.
Wei Jiang, Liang Chen, Sika Zheng
doaj   +1 more source

In utero tobacco smoke exposure, DNA methylation, and asthma in Latino children. [PDF]

, 2019
BackgroundMaternal smoking during pregnancy is a risk factor for chronic disease later in life and has been associated with variability of DNA methylation at specific cytosine-phosphate-guanine (CpG) loci.
Barker, Beach, Beamer, Best, Cardenas, Chhabra, Cunningham, DiFranza, Galanter, Gibbs, Gilliland, Gilliland, Gilliland, Hanieh, Harb, Hu, Jaakkola, Jauniaux, Joubert, Joubert, Küpers, Lara, Morales, Oh, Perreira, Pickett, Rahmani, Reese, Reese, Rehan, Richiardi, Richmond, Richmond, Sharma, Shorey-Kendrick, Stick, Stocks, Tong, Upton, van der Laan, Vanderweele, VanderWeele, Waterland, Wongtrakool, Wu, Zeilinger, Zhang, Zhong   +47 more
core   +1 more source

Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer

Advanced Science, EarlyView.
Breast cancer cells undergo metabolic and transcriptomic reprogramming to support aberrant cell proliferation. Their mitochondria rely on the transfer of phosphatidylcholine from the endoplasmic reticulum to their membranes by STARD7, a candidate upregulated in breast cancer, to be functional.
Ewelina Dondajewska, Paula Allepuz‐Fuster, Chloé Maurizy, Alexandre Hego, Sandra Ormenese, Quentin Lion, Arnaud Blomme, Pierre Close, Arnaud Lavergne, Latifa Karim, Marc Thiry, Ivan Nemazanyy, Roopesh Krishnankutty, Jair Marques Jr, Alex von Kriegsheim, Nathaniel F. Henneman, Ganna Panasyuk, Kateryna Shostak, Alain Chariot   +18 more
wiley   +1 more source

Transcription factor LSF-DNMT1 complex dissociation by FQI1 leads to aberrant DNA methylation and gene expression [PDF]

, 2016
The transcription factor LSF is highly expressed in hepatocellular carcinoma (HCC) and promotes oncogenesis. Factor quinolinone inhibitor 1 (FQI1), inhibits LSF DNA-binding activity and exerts anti-proliferative activity.
Chin, Hang Gyeong, Esteve, Pierre-Olivier, Hansen, Ulla, Ponnaluri, V. K. Chaithanya, Pradhan, Sriharsa, Schaus, Scott E., Zhang, Guoqiang   +6 more
core   +1 more source