Results 81 to 90 of about 21,621 (295)
Genetic and epigenetic variation in the lineage specification of regulatory T cells
eLife, 2015 Regulatory T (Treg) cells, which suppress autoimmunity and other inflammatory states, are characterized by a distinct set of genetic elements controlling their gene expression.
Aaron Arvey +5 more
doaj +1 more source
Microorganisms, 2021 DNA methylation is a common, but not universal, epigenetic modification that plays an important role in multiple cellular processes. While definitely settled for numerous plant, mammalian, and bacterial species, the genome methylation in different fungal
Monika Kubiak-Szymendera +3 more
doaj +1 more source
Higher order methylation features for clustering and prediction in epigenomic studies [PDF]
Bioinformatics (2016) 32 (17): i405-i412, 2016 Motivation: DNA methylation is an intensely studied epigenetic mark, yet its functional role is incompletely understood. Attempts to quantitatively associate average DNA methylation to gene expression yield poor correlations outside of the well-understood methylation-switch at CpG islands.
arxiv +1 more source
Advanced NanoBiomed Research, EarlyView.This study presents an innovative approach to evaluate cell‐mediated biomineralization using μ‐X‐ray fluorescence spectroscopy. By generating elemental maps, the evaluation of mineral deposition by osteoblasts can be assessed in terms of both spatial distribution and degree of maturity.
Mathieu Y. Brunet +4 more
wiley +1 more source
Global Reprogramming of Apoptosis-Related Genes during Brain Development
Cells, 2021 To enable long-term survival, mammalian adult neurons exhibit unique apoptosis competence. Questions remain as to whether and how neurons globally reprogram the expression of apoptotic genes during development.
Wei Jiang, Liang Chen, Sika Zheng
doaj +1 more source
Bayesian Genome- and Epigenome-wide Association Studies with Gene Level Dependence [PDF]
Biometrics 73(3), 1018-1028, 2017, 2016 High-throughput genetic and epigenetic data are often screened for associations with an observed phenotype. For example, one may wish to test hundreds of thousands of genetic variants, or DNA methylation sites, for an association with disease status. These genomic variables can naturally be grouped by the gene they encode, among other criteria. However,
arxiv +1 more source
Clinical Epigenetics, 2021 Coronary heart disease (CHD) is a type of cardiovascular disease (CVD) that affects the coronary arteries, which provide oxygenated blood to the heart. It is a major cause of mortality worldwide.
Yujing Xia, A. Brewer, J. Bell
semanticscholar +1 more source
Cancer Medicine, 2019 Next‐generation sequencing (NGS) technology is currently used to establish mutational profiles in many heterogeneous diseases. The aim of this study was to evaluate the mutational spectrum in Taiwanese patients with colorectal cancer (CRC) to help ...
Ya‐Sian Chang +6 more
doaj +1 more source
Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain
Cell Reports, 2016 Organoids derived from human pluripotent stem cells recapitulate the early three-dimensional organization of the human brain, but whether they establish the epigenomic and transcriptional programs essential for brain development is unknown.
Chongyuan Luo +5 more
doaj +1 more source
Maternal Mineral Nutrition Regulates Fetal Genomic Programming in Cattle: A Review
Metabolites, 2023 Maternal mineral nutrition during the critical phases of fetal development may leave lifetime impacts on the productivity of an individual. Most research within the developmental origins of the health and disease (DOHaD) field is focused on the role of ...
Muhammad Anas +6 more
doaj +1 more source