Results 41 to 50 of about 607,096 (382)

Functional epitopes and neutralizing antibodies of vaccinia virus

Frontiers in Microbiology, 2023
Smallpox is an infectious disease caused by the variola virus, and it has a high mortality rate. Historically it has broken out in many countries and it was a great threat to human health.
Fenghao Peng, Naijing Hu, Yingjun Liu, Cong Xing, Longlong Luo, Xinying Li, Jing Wang, Guojiang Chen, He Xiao, Chenghua Liu, Beifen Shen, Jiannan Feng, Chunxia Qiao   +12 more
doaj   +1 more source

Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites [PDF]

, 2016
Autoantibodies to insulin are a harbinger of autoimmunity in type 1 diabetes in humans and in non-obese diabetic mice. To understand the genesis of these autoantibodies, we investigated the interactions of insulin-specific T and B lymphocytes using T ...
Acevedo-Suárez, Achenbach, Adelstein, Akashi, Batista, Bodansky, Cooke, Crotty, Dean, Emil R. Unanue, Ferris, Gagnerault, Garside, Gitlin, Glazier, Goodnow, Greeley, Gretz, Harbers, Henry, Henry, Henry-Bonami, Hoppu, Hu, Hulbert, Höglund, James W. Thomas, Kendall, Kendall, Kenefeck, Levisetti, Linterman, Mariño, Mohan, Mohan, Mohan, Nakayama, Noorchashm, Okada, Pape, Rasio, Reinhardt, Rojas, Roozendaal, Serreze, Silva, Takahashi, Ueno, Unanue, Victora, Victora, Vinuesa, Vomund, Williams, Xiaoxiao Wan, Yang, Zhang, Zhang, Zikherman, Zotos   +59 more
core   +2 more sources

IEDB-AR: immune epitope database—analysis resource in 2019

Nucleic Acids Res., 2019
The Immune Epitope Database Analysis Resource (IEDB-AR, http://tools.iedb.org/) is a companion website to the IEDB that provides computational tools focused on the prediction and analysis of B and T cell epitopes.
Sandeep Kumar Dhanda, Swapnil Mahajan, S. Paul, Zhen Yan, Haeuk Kim, M. C. Jespersen, V. Jurtz, M. Andreatta, J. Greenbaum, P. Marcatili, A. Sette, M. Nielsen, Bjoern Peters   +12 more
semanticscholar   +1 more source

Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in Human Immunodeficiency Virus Type 1 infection [PDF]

, 2004
Numerous studies now support that human immunodeficiency virus type 1 (HIV-1) evolution is influenced by immune selection pressure, with population studies showing an association between specific HLA alleles and mutations within defined cytotoxic T ...
Allen, T.M., Altfeld, M., Brander, C., Cohen, D.E., Freedberg, K.A., Goulder, P.J.R., John, M., Johnston, M.N., Kalife, E.T., Le Gall, S., Lee, P.K., Lichterfeld, M., Mallal, S.A., Mothe, B.R., O'Sullivan, K.M., Rosenberg, E.S., Sette, A., Strick, D.A., Walker, B.D., Yu, X.G.   +19 more
core   +2 more sources

Advances in the Characterization of the T-Cell Response to Human Herpesvirus-6

Frontiers in Immunology, 2018
Human herpesvirus (HHV) 6 is thought to remain clinically latent in most individuals after primary infection and to reactivate to cause disease in persons with severe immunosuppression.
Derek J. Hanson, Derek J. Hanson, Joshua A. Hill, Joshua A. Hill, David M. Koelle, David M. Koelle, David M. Koelle, David M. Koelle, David M. Koelle   +8 more
doaj   +1 more source

The amino acids differences in epitopes may promote the different allergenicity of ovomucoid derived from hen eggs and quail eggs

Food Science and Human Wellness, 2023
Quail egg ovomucoid can inhibit activation of basophils and eosinophils, while hen egg ovomucoid has been shown to be a major allergen, named Gal d 1. At present, the differences in structure and function between two ovomucoid are unclear.
Mengzhen Hao, Shuai Yang, Shiwen Han, Huilian Che   +3 more
doaj   +1 more source

In-silico design of a multi-epitope vaccine candidate against onchocerciasis and related filarial diseases

Scientific Reports, 2019
Onchocerciasis is a parasitic disease with high socio-economic burden particularly in sub-Saharan Africa. The elimination plan for this disease has faced numerous challenges. A multi-epitope prophylactic/therapeutic vaccine targeting the infective L3 and
R. A. Shey, S. Ghogomu, K. Esoh, Neba Derrick Nebangwa, C. M. Shintouo, Nkemngo Francis Nongley, B. F. Asa, Ferdinand Njume Ngale, L. Vanhamme, J. Souopgui   +9 more
semanticscholar   +1 more source

Structural Influence on the Dominance of Virus-Specific CD4 T Cell Epitopes in Zika Virus Infection

Frontiers in Immunology, 2018
Zika virus (ZIKV) has recently caused explosive outbreaks in Pacific islands, South- and Central America. Like with other flaviviruses, protective immunity is strongly dependent on potently neutralizing antibodies (Abs) directed against the viral ...
Maximilian Koblischke, Karin Stiasny, Stephan W. Aberle, Stefan Malafa, Georgios Tsouchnikas, Julia Schwaiger, Michael Kundi, Franz X. Heinz, Judith H. Aberle   +8 more
doaj   +1 more source

Thermal and Acidic Treatments of Gluten Epitopes Affect Their Recognition by HLA-DQ2 in silico

Frontiers in Nutrition, 2021
Celiac disease (CD) is a prevalent disorder with autoimmune features. Dietary exposure of wheat gluten (including gliadins and glutenins) to the small intestine activates the gluten-reactive CD4+ T cells and controls the disease development.
Jihui Gao, Haolan Du, Zekun Zhou, Zhongxin Liang, Hongrui Liang, PeiAo Zhang, Xue Wei, Shujun Liu, Linglin Fu, Yanbo Wang, Huilian Che, Wentong Xue, Fengjiao Xin, Dong Yang   +13 more
doaj   +1 more source

The Humoral Theory of Transplantation: Epitope Analysis and the Pathogenicity of HLA Antibodies. [PDF]

, 2016
Central to the humoral theory of transplantation is production of antibodies by the recipient against mismatched HLA antigens in the donor organ. Not all mismatches result in antibody production, however, and not all antibodies are pathogenic.
Farber, John, Filippone, Edward J
core   +4 more sources