Results 41 to 50 of about 552,242 (397)

A large peptidome dataset improves HLA class I epitope prediction across most of the human population

Nature Biotechnology, 2019
Prediction of HLA epitopes is important for the development of cancer immunotherapies and vaccines. However, current prediction algorithms have limited predictive power, in part because they were not trained on high-quality epitope datasets covering a ...
Siranush Sarkizova, Susan Klaeger, Phuong M. Le, Letitia W. Li, G. Oliveira, Hasmik Keshishian, Christina R. Hartigan, Wandi Zhang, D. Braun, K. Ligon, P. Bachireddy, I. Zervantonakis, Jennifer M. Rosenbluth, Tamara Ouspenskaia, Travis Law, S. Justesen, Jonathan D. Stevens, W. Lane, T. Eisenhaure, Guang Lan Zhang, K. Clauser, N. Hacohen, S. Carr, Catherine J. Wu, D. Keskin   +24 more
semanticscholar   +1 more source

Current challenges for unseen-epitope TCR interaction prediction and a new perspective derived from image classification

Briefings Bioinform., 2020
The prediction of epitope recognition by T-cell receptors (TCRs) has seen many advancements in recent years, with several methods now available that can predict recognition for a specific set of epitopes.
Pieter Moris, Joey De Pauw, A. Postovskaya, Sofie Gielis, Nicolas De Neuter, Wout Bittremieux, B. Ogunjimi, K. Laukens, P. Meysman   +8 more
semanticscholar   +1 more source

IgE-binding epitopes: a reappraisal [PDF]

Allergy, 2011
Here, we discuss various questions related to IgE epitopes: What are the technical possibilities and pitfalls, what is currently known, how can we put this information into hypothetical frameworks and the unavoidable question: how useful is this information for patient care or allergenicity prediction?
Aalberse, R.C., Crameri R.
openaire   +3 more sources

Epitope Addition and Ablation via Manipulation of a Dengue Virus Serotype 1 Infectious Clone

mSphere, 2017
Despite the clinical relevance, dengue virus (DENV) research has been hampered by the absence of robust reverse genetic systems to manipulate the viral serotypes for propagation and generation of mutant viruses.
Emily N. Gallichotte, Vineet D. Menachery, Boyd L. Yount, Douglas G. Widman, Kenneth H. Dinnon, Steven Hartman, Aravinda M. de Silva, Ralph S. Baric   +7 more
doaj   +1 more source

Quantitative Prediction of Linear B-Cell Epitopes [PDF]

Biomedical Statistics and Informatics. Vol. 2, No.1, 2017, pp.1-3, 2017
In scientific literature, there are many programs that predict linear B-cell epitopes from a protein sequence. Each program generates multiple B-cell epitopes that can be individually studied. This paper defines a function called that combines results from five different prediction programs concerning the linear B-cell epitopes (ie., BebiPred ...
arxiv   +1 more source

Characterization and epitope mapping of human monoclonal antibodies to PDC-E2, the immunodominant autoantigen of primary biliary cirrhosis [PDF]

, 1992
Further to define the epitopes of PDC-E2, the major autoantigen in primary biliary cirrhosis (PBC), we have developed and characterized five human monoclonal antibodies. These antibodies were derived by fusing a regional hepatic lymph node from a patient
Bassendine, Baum, Casali, Chambers, Coppel, Coppel, Cram, Flannery, Fregeau, Fregeau, Fujikura, Fusey, Fussey, Gershwin, Gershwin, Griffin, Griffin, James, Kaplan, Kunicki, Larrick, Leung, Leung, Mackay, Mackay, Mathews, McNeilage, Okamoto, Pollack, Ramsden, Reeves, Reimer, Robbins, Rokeach, Rowley, Ruther, Salemuddin, Sturgess, Sudin, Surh, Surh, Surh, Surh, Tan, Uibo, Van de Water, Van de Water, Van de Water, Van de Water, Williams   +49 more
core   +1 more source

Epitope recognition of peptide-imprinted polymers for Regenerating protein 1 (REG1) [PDF]

, 2018
Molecularly imprinted polymers (MIPs) were developed to replace natural antibodies with a cost-effective and durable synthetic material. Molecular imprinting of proteins conventionally utilizes the whole protein as the template, which is complex (as many
Crnogorac-Jurcevic, T., Crnogorac-Jurcevic, T., Jurcevic, S., Jurcevic, S., Lee, M.H., Lee, M.H., Liao, C.L., Liao, C.L., Lin, H.Y., Lin, H.Y., Thomas, J.L., Thomas, J.L.   +11 more
core   +1 more source

Fundamentals and Methods for T- and B-Cell Epitope Prediction

Journal of Immunological Research, 2017
Adaptive immunity is mediated by T- and B-cells, which are immune cells capable of developing pathogen-specific memory that confers immunological protection.
J. L. Sánchez-Trincado, Marta Gomez-Perosanz, P. Reche   +2 more
semanticscholar   +1 more source

Finding Epitopes with Computers

Chemistry & Biology, 2013
The goal of structural vaccinology is to enable the design and engineering of improved antigens. In a recent issue of Chemistry & Biology, Gourlay and colleagues provided evidence that structure-based computational methods allow prediction of B cell epitopes, a crucial step for antigen selection and optimization in vaccine development.
Rino Rappuoli, Enrico Malito
openaire   +3 more sources

Molecular construction of HIV-gp120 discontinuous epitope mimics by assembly of cyclic peptides on an orthogonal alkyne functionalized TAC-scaffold [PDF]

, 2016
Mimics of discontinuous epitopes of for example bacterial or viral proteins may have considerable potential for the development of synthetic vaccines, especially if conserved epitopes can be mimicked. However, due to the structural complexity and size of
Elwakiel, M., Kruijtzer, J.A.W., Liskamp, R.M.J., Meuleman, T.J., Quarles van Ufford, H.C., Werkhoven, P.R.   +5 more
core   +2 more sources