Results 61 to 70 of about 591,359 (390)

Better Epitope Discovery, Precision Immune Engineering, and Accelerated Vaccine Design Using Immunoinformatics Tools

Frontiers in Immunology, 2020
Computational vaccinology includes epitope mapping, antigen selection, and immunogen design using computational tools. Tools that facilitate the in silico prediction of immune response to biothreats, emerging infectious diseases, and cancers can ...
Anne Searls De Groot, L. Moise, Frances E Terry, A. Gutiérrez, P. Hindocha, Guilhem Richard, D. Hoft, T. Ross, A. Noe, Yoshimasa Takahashi, V. Kotraiah, S. Silk, C. Nielsen, A. Minassian, R. Ashfield, M. Ardito, S. Draper, W. Martin   +17 more
semanticscholar   +1 more source

Potential SARS-CoV-2 Preimmune IgM Epitopes

Frontiers in Immunology, 2020
While studying the human public IgM igome as represented by a library of 224,087 linear mimotopes, three exact matches to peptides in the proteins of SARS-CoV-2 were found: two in the open reading frame 1ab and one in the spike protein.
Velizar Shivarov, Velizar Shivarov, Peter K. Petrov, Anastas D. Pashov   +3 more
doaj   +1 more source

Prediction of T-Cell Epitope

Journal of Pharmacological Sciences, 2007
The prevailing methods to predict T-cell epitopes are reviewed. Motif matching, matrix, support vector machine (SVM), and empirical scoring function methods are mainly reviewed; and the thermodynamic integration (TI) method using all-atom molecular dynamics (MD) simulation is mentioned briefly.
Takuya Takahashi, Hiromichi Tsurui
openaire   +5 more sources

Epitope mapping for the anti-rabbit cholesteryl ester transfer protein monoclonal antibody that selectively inhibits triglyceride transfer

Journal of Lipid Research, 1999
Among the monoclonal antibodies (Mab) against rabbit plasma cholesteryl ester transfer protein (CETP), Mab 14-8F cross-reacted with human CETP and selectively inhibited triglyceride transfer but not cholesteryl ester transfer (Ko, K. W. S., T.
Kazunori Saito, Ki-ichiro Kobori, Hideyuki Hashimoto, Sachiko Ito, Mitsuhisa Manabe, Shinji Yokoyama   +5 more
doaj   +1 more source

Defining the epichromatin epitope [PDF]

Nucleus, 2017
Epichromatin is identified by immunostaining fixed and permeabilized cells with particular bivalent anti-nucleosome antibodies (mAbs PL2-6 and 1H6). During interphase, epichromatin resides adjacent to the inner nuclear membrane; during mitosis, at the outer surface of mitotic chromosomes.
Travis J. Gould, Katalin Tóth, Norbert Mücke, Jörg Langowski, Alexandra S. Hakusui, Ada L. Olins, Donald E. Olins   +6 more
openaire   +3 more sources

IEDB-AR: immune epitope database—analysis resource in 2019

Nucleic Acids Res., 2019
The Immune Epitope Database Analysis Resource (IEDB-AR, http://tools.iedb.org/) is a companion website to the IEDB that provides computational tools focused on the prediction and analysis of B and T cell epitopes.
Sandeep Kumar Dhanda, Swapnil Mahajan, S. Paul, Zhen Yan, Haeuk Kim, M. C. Jespersen, V. Jurtz, M. Andreatta, J. Greenbaum, P. Marcatili, A. Sette, M. Nielsen, Bjoern Peters   +12 more
semanticscholar   +1 more source

TCRMatch: Predicting T-Cell Receptor Specificity Based on Sequence Similarity to Previously Characterized Receptors

Frontiers in Immunology, 2021
The adaptive immune system in vertebrates has evolved to recognize non-self antigens, such as proteins expressed by infectious agents and mutated cancer cells.
William D. Chronister, Austin Crinklaw, Swapnil Mahajan, Randi Vita, Zeynep Koşaloğlu-Yalçın, Zhen Yan, Jason A. Greenbaum, Leon E. Jessen, Morten Nielsen, Morten Nielsen, Scott Christley, Lindsay G. Cowell, Alessandro Sette, Alessandro Sette, Bjoern Peters, Bjoern Peters   +15 more
doaj   +1 more source

In-silico design of a multi-epitope vaccine candidate against onchocerciasis and related filarial diseases

Scientific Reports, 2019
Onchocerciasis is a parasitic disease with high socio-economic burden particularly in sub-Saharan Africa. The elimination plan for this disease has faced numerous challenges. A multi-epitope prophylactic/therapeutic vaccine targeting the infective L3 and
R. A. Shey, S. Ghogomu, K. Esoh, Neba Derrick Nebangwa, C. M. Shintouo, Nkemngo Francis Nongley, B. F. Asa, Ferdinand Njume Ngale, L. Vanhamme, J. Souopgui   +9 more
semanticscholar   +1 more source

Impact of HLA Epitope Matching on Outcomes After Unrelated Bone Marrow Transplantation

Frontiers in Immunology, 2022
The significance of antibody-identified epitopes stimulating humoral alloimmunity is not well understood in the identification of non-permissive human leukocyte antigen (HLA) mismatching patterns in hematopoietic stem cell transplantation (HSCT).
Makoto Iwasaki, Junya Kanda, Hidenori Tanaka, Takero Shindo, Takahiko Sato, Noriko Doki, Takahiro Fukuda, Yukiyasu Ozawa, Tetsuya Eto, Naoyuki Uchida, Yuta Katayama, Keisuke Kataoka, Takahide Ara, Shuichi Ota, Makoto Onizuka, Yoshinobu Kanda, Tatsuo Ichinohe, Yoshiko Atsuta, Yoshiko Atsuta, Satoko Morishima   +19 more
doaj   +1 more source

Determination of a predictive cleavage motif for eluted major histocompatibility complex class II ligands [PDF]

, 2018
CD4+ T cells have a major role in regulating immune responses. They are activated by recognition of peptides mostly generated from exogenous antigens through the major histocompatibility complex (MHC) class II pathway.
Dhanda, Sandeep Kumar, Edwards, Lindy, Jurtz, Vanessa, Karosiene, Edita, Nielsen, Morten, Paul, Sinu, Peters, Bjoern, Sette, Alessandro   +7 more
core   +6 more sources