Results 11 to 20 of about 12,449,745 (282)

Epitope-directed processing of specific antigen by B lymphocytes. [PDF]

The Journal of cell biology, 1989
Proteolytic processing of specific antigen was studied using Epstein Barr virus transformed B-lymphoblastoid cells expressing membrane IgG against tetanus toxin. As previously reported (Watts, C., and H.W. Davidson. 1988. EMBO (Eur. Mol. Biol. Organ.) J.
Davidson, H. W., Watts, C.
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Sporozoite glycoprotein antigen (SGA) of Cryptosporidium parvum is a promising vaccine target for prevention of cryptosporidiosis In silico analysis of C. parvum SGA protein

Informatics in Medicine Unlocked, 2023
Cryptosporidiosis is a zoonotic parasitic infection causing diarrhea in humans and farm animals. The present study was done to computationally analyze the Cryptosporidium parvum sporozoite glycoprotein antigen (SGA) regarding immunogenic epitopes, as a ...
Bahareh Kordi, Amir Fotovati, Hamidreza Majidiani, Hadi Fazel, Esfandiar Azizi, Morteza Shams, Amir Abaszadeh   +6 more
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PP19128R, a Multiepitope Vaccine Designed to Prevent Latent Tuberculosis Infection, Induced Immune Responses In Silico and In Vitro Assays

Vaccines, 2023
Background: Latent tuberculosis infection (LTBI) is the primary source of active tuberculosis (ATB), but a preventive vaccine against LTBI is lacking. Methods: In this study, dominant helper T lymphocyte (HTL), cytotoxic T lymphocyte (CTL), and B-cell ...
Fan Jiang, Cong Peng, Peng Cheng, Jie Wang, Jianqi Lian, Wenping Gong   +5 more
doaj   +1 more source

Recombinant staphylokinase variants with reduced antigenicity due to elimination of B-lymphocyte epitopes [PDF]

Blood, 2000
Abstract Site directed mutagenesis (350 variants) of recombinant staphylokinase (SakSTAR), a potent fibrin-selective thrombolytic agent, was undertaken in order to reduce its antigenicity while maintaining its potency. Variants with K35A, (ie, Lys[K] in position 35 substituted with Ala[A]), E65D or E65Q, K74R or K74Q, E80A+D82A, K130T ...
Y, Laroche, S, Heymans, S, Capaert, F, De Cock, E, Demarsin, D, Collen   +5 more
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Molecular modelling of epitopes recognized by neoplastic B lymphocytes in Chronic Lymphocytic Leukemia

European Journal of Medicinal Chemistry, 2020
Identification of epitopes recognized by tumour B cells could provide insights into the molecular mechanisms of B cell tumorigenesis through aberrant B cell receptor (BCR) signalling. Here, we analysed the structure of eleven peptides binders of BCRs expressed in Chronic Lymphocytic Leukemia (CLL) patients in order to identify the chemical features ...
Antonio Lupia, Selena Mimmi, Enrico Iaccino, Domenico Maisano, Federica Moraca, Carmine Talarico, Eleonora Vecchio, Giuseppe Fiume, Francesco Ortuso, Giuseppe Scala, Ileana Quinto, Stefano Alcaro   +11 more
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Protein-engineered molecules carrying GAD65 epitopes and targeting CD35 selectively down-modulate disease-associated human B lymphocytes [PDF]

Clinical and Experimental Immunology, 2019
Summary Type 1 diabetes mellitus is an autoimmune metabolic disorder characterized by chronic hyperglycemia, the presence of autoreactive T and B cells and autoantibodies against self-antigens. A membrane-bound enzyme on the pancreatic beta-cells, glutamic acid decarboxylase 65 (GAD65), is one of the main autoantigens in type 1 diabetes.
I K Manoylov, G V Boneva, I A Doytchinova, N M Mihaylova, A I Tchorbanov   +4 more
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Novel, cross-restricted, conserved, and immunodominant Cytotoxic T Lymphocyte epitopes in slow progressors in HIV Type 1 infection [PDF]

, 1996
HIV-specific cytotoxic T lymphocytes (CTLs) play an important role in the immune response to HIV infection. Long-term nonprogressors (LTNPs) or slow progressors (SPs) in HIV infection may make qualitatively different CTL responses compared to those ...
KARL McINTYRE, RODNEY E. PHILLIPS, Phillips, Rodney, Krausa, P, Phillips, R.E., Giangrande, P, SIOBHAN CROWLEY, Edwards, A., McIntyre, K., MIKE BUNCE, Morgan, B., Edwards, A, McMichael, A.J., Crowley, S, BARBARA MORGAN, ANNE EDWARDS, Morgan, B, Bunce, M, McMichael, Andrew, PETER KRAUSA, Crowley, S., Krausa, P., Goulder, P.J.R., Goulder, PJ, McIntyre, K, PAUL GIANGRANDE, ANDREW J. McMICHAEL, Giangrande, P., PHILIP J.R. GOULDER, McMichael, AJ, Bunce, M., Phillips, RE   +31 more
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Designing a multi-epitope vaccine to control porcine epidemic diarrhea virus infection using immunoinformatics approaches

Frontiers in Microbiology, 2023
Porcine epidemic diarrhea virus (PEDV), a continuously evolving pathogen, causes severe diarrhea in piglets with high mortality rates. However, current vaccines cannot provide complete protection against PEDV, so vaccine development is still necessary ...
Wei Hou, Heqiong Wu, Sibei Wang, Wenting Wang, Bin Wang, Bin Wang, Haidong Wang   +6 more
doaj   +1 more source

Differential narrow focusing of immunodominant human immunodeficiency virus Gag-specific cytotoxic T-Lymphocyte responses in infected African and Caucasoid adults and children [PDF]

, 2000
Cytotoxic T-lymphocyte (CTL) activity plays a central role in control of viral replication and in determining outcome in cases of human immunodeficiency virus type 1 (HIV-1) infection.
Ogg, GS, Coovadia, HM, O'Callaghan, CA, Kalams, SA, Mngqundaniso, N., Altfeld, M.A., Hammond, M., He, S, He, S., O'Callaghan, C.A., Tang, Y, Burchett, S.A., Walker, B.D., Rosenberg, ES, Burchett, SA, Pelton, SI, McIntosh, K, Annamalai, K, Annamalai, K., Cao, H, Walker, BD, Bunce, M, McIntosh, K., Coovadia, H.M., Kalams, S.A., Rosenberg, E.S., Govender, U., Brander, C, Goulder, P.J.R., Brander, C., Goulder, PJ, Hammond, M, O'Callaghan, Christopher, Mngqundaniso, N, Cao, H., Altfeld, MA, Ogg, G.S., Hartman, K.E., Pelton, S.I., Govender, U, Hartman, KE, Tang, Y., Bunce, M.   +42 more
core   +1 more source

Genetically Transferred Central and Peripheral Immune Tolerance via Retroviral-Mediated Expression of Immunogenic Epitopes in Hematopoietic Progenitors or Peripheral B Lymphocytes [PDF]

Molecular Medicine, 1997
Based on the hypothesis that IgGs are potent tolerogens and that immature lymphohematopoietic antigen-presenting cells (APC), and even mature peripheral B cells, may be effective APC for tolerance induction, we designed an immunoglobulin fusion protein retroviral expression vector to test the role of B cells in a novel gene therapy strategy for the ...
E T, Zambidis, A, Kurup, D W, Scott
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