Results 21 to 30 of about 12,449,745 (282)

Anaplasma marginale major surface protein 2 CD4+-T-cell epitopes are evenly distributed in conserved and hypervariable regions (HVR), whereas linear B-cell epitopes are predominantly located in the HVR [PDF]

, 2004
Organisms in the genus Anaplasma express an immunodominant major surface protein 2 (MSP2), composed of a central hypervariable region (HVR) flanked by highly conserved regions.
Abbott, Jeffrey R, Brown, Wendy C, Howard, Chris J, Palmer, Guy H, Brown, Wendy C., Hope, Jayne; id_orcid, Hope, Jayne C   +6 more
core   +1 more source

Mapping T and B lymphocyte epitopes of bovine herpesvirus-1 glycoprotein B

Journal of General Virology, 1999
Glycoprotein B (gB) is a major envelope protein of bovine herpesvirus-1 (BHV-1). As a subunit vaccine, the extracellular domain of recombinant gB induces neutralizing antibody and T cell responses that engender protection against virus challenge. Here, lymphocytes from animals of different parentage were analysed for T cell proliferation to the gB ...
Yi, Gao, Chong, Wang, Gary A, Splitter
openaire   +2 more sources

Suppressive Effect of Glutamic Acid Decarboxylase 65-Specific Autoimmune B Lymphocytes on Processing of T Cell Determinants Located Within the Antibody Epitope [PDF]

The Journal of Immunology, 2002
Abstract Type 1 diabetes is a T cell-mediated disease in which B cells serve critical Ag-presenting functions. In >95% of type 1 diabetic patients the B cell response to the glutamic acid decarboxylase 65 (GAD65) autoantigen is exclusively directed at conformational epitopes residing on the surface of the native molecule.
Jaume, J. C., Parry, S. L., Madec, A.-M., Sonderstrup, G., Baekkeskov, S.   +4 more
openaire   +3 more sources

Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in Human Immunodeficiency Virus Type 1 infection [PDF]

, 2004
Numerous studies now support that human immunodeficiency virus type 1 (HIV-1) evolution is influenced by immune selection pressure, with population studies showing an association between specific HLA alleles and mutations within defined cytotoxic T ...
O'Sullivan, K.M., Mothe, B.R., Kalife, ET, Johnston, MN, Altfeld, M., Kalife, E.T., Strick, D.A., Lee, PK, Yu, X.G., Mallal, SA, Walker, B.D., Rosenberg, ES, Mothe, BR, Allen, T.M., Cohen, D.E., Altfeld, M, Sette, A., Walker, BD, Sette, A, John, M., Johnston, M.N., Rosenberg, E.S., O'Sullivan, KM, Le Gall, S, Allen, TM, Brander, C, John, M, Goulder, P.J.R., Brander, C., Goulder, PJ, Lichterfeld, M, Freedberg, K.A., Cohen, DE, Freedberg, KA, Mallal, S.A., Lee, P.K., Yu, XG, Le Gall, S., Lichterfeld, M., Strick, DA   +39 more
core   +1 more source

HLA-B*35-restricted CD8 T cell epitopes in the antigen 85 complex of Mycobacterium tuberculosis. [PDF]

, 2001
Few target epitopes have been described for human CD8 T lymphocytes in antigens of Mycobacterium tuberculosis. By use of a reverse immunogenetics approach, 23 motif-bearing peptides of the Ag85 complex were tested for binding to HLA-B*35, one of the ...
Ogg, GS, Jaye, A, Klein, MR, Lukey, PT, Hammond, AS, King, AS, McAdam, KP, Vekemans, J, Smith, SM   +8 more
core   +1 more source

In silico design of a promiscuous chimeric multi-epitope vaccine against Mycobacterium tuberculosis

Computational and Structural Biotechnology Journal, 2023
Tuberculosis (TB) is a global health threat, killing approximately 1.5 million people each year. The eradication of Mycobacterium tuberculosis, the main causative agent of TB, is increasingly challenging due to the emergence of extensive drug-resistant ...
Binda T. Andongma, Yazheng Huang, Fang Chen, Qing Tang, Min Yang, Shan-Ho Chou, Xinfeng Li, Jin He   +7 more
doaj   +1 more source

De Novo generation of escape Variant-specific CD8+ T-Cell responses following Cytotoxic T-Lymphocyte escape in chronic Human Immunodeficiency Virus Type 1 Infection [PDF]

, 2005
Human immunodeficiency virus type 1 (HIV-1) evades CD8+ T-cell responses through mutations within targeted epitopes, but little is known regarding its ability to generate de novo CD8+ T-cell responses to such mutants.
Allgaier, R.L., Cheng, M., Galit Alter, Altfeld, M., Elizabeth T. Kalife, Frahm, N., Xu G. Yu, Kalife, E.T., Marcus Altfeld, Michael Cheng, Yu, X.G., Walker, B.D., Laura L. Reyor, Mui, S., Allen, T.M., Reyor, L.L., Christian Brander, Alter, G., Mathias Lichterfeld, Eric S. Rosenberg, Rachel L. Allgaier, Todd M. Allen, Simon A. Mallal, Nancy V. Brown, John, M., Nicole Frahm, Johnston, M.N., Rosenberg, E.S., Brown, N.V., Brander, C., Bruce D. Walker, Mina John, Mary N. Johnston, Mallal, S.A., Stanley Mui, Lichterfeld, M.   +35 more
core   +1 more source

The MEV model in complex with the TLR4; dark green and orange: Adjuvant, dark blue: Helper T lymphocyte epitopes, red: B cell epitopes, blue: Cytotoxic T lymphocyte epitopes, green: TLR4 and red: Hydrogen bonds.

, 2023
The MEV model in complex with the TLR4; dark green and orange: Adjuvant, dark blue: Helper T lymphocyte epitopes, red: B cell epitopes, blue: Cytotoxic T lymphocyte epitopes, green: TLR4 and red: Hydrogen bonds.
Javad Zamani Amirzakaria (15419294), Shirin Mahmoodi (15419291), Abdolmajid Ghasemian (13531687)   +2 more
core   +1 more source

Rapid and long-term disappearance of CD4+ T lymphocyte responses specific for Anaplasma marginale major surface protein-2 (MSP2) in MSP2 vaccinates following challenge with live A. marginale [PDF]

, 2005
In humans and ruminants infected with Anaplasma, the major surface protein 2 (MSP2) is immunodominant. Numerous CD4(+) T cell epitopes in the hypervariable and conserved regions of MSP2 contribute to this immunodominance.
Abbott, Jeffrey R, Howard, Chris J, Palmer, Guy H, Kegerreis, Kimberly A, Brown, Wendy C, Hope, Jayne; id_orcid, Hope, Jayne C, Hetrick, Peter F   +7 more
core   +1 more source

An investigation into the role of autoimmunity in vitiligo [PDF]

, 2002
Vitiligo is an acquired depigmenting disorder characterised by the loss of functional melanocytes from the cutaneous epidermis. A role for autoimmunity is supported by the presence of circulating antibodies and T lymphocytes which react against ...
Waterman, Elizabeth Ann
core   +6 more sources