Results 1 to 10 of about 34,322 (91)

Application of the pMHC array to characterise tumour antigen specific T cell populations in leukaemia patients at disease diagnosis [PDF]

, 2015
Immunotherapy treatments for cancer are becoming increasingly successful, however to further improve our understanding of the T-cell recognition involved in effective responses and to encourage moves towards the development of personalised treatments for
Arno, Matthew, Banham, Alison H., Bonney, Stephanie A., Brooks, Suzanne E., Elliott, Tim J., Guinn, Barbara-Ann, Khan, Ghazala, Lee, Cindy, Li, Demin, Mills, Ken I., Mufti, Ghulam J., Orchard, Kim H., Publicover, Amy, Pulford, Karen, Rammensee, Hans-Georg, Sigurdardottir, Dagmar, Smits, Evelien L.J., van Tendeloo, Viggo   +17 more
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Common Antiviral Cytotoxic T-Lymphocyte Epitope for Diverse Arenaviruses [PDF]

Journal of Virology, 2001
ABSTRACT Members of the Arenaviridae family have been isolated from mammalian hosts in disparate geographic locations, leading to their grouping as Old World types (i.e., lymphocytic choriomeningitis virus [LCMV], Lassa fever virus [LFV], Mopeia virus, and Mobala virus) and New World types (i.e., Junin ...
Jean Edouard Gairin, Hanna Lewicki, Michael B. A. Oldstone, Christophe Nguyen, Dirk Homann, Sylvianne Julien   +5 more
openaire   +3 more sources

Epitope-directed processing of specific antigen by B lymphocytes. [PDF]

The Journal of cell biology, 1989
Proteolytic processing of specific antigen was studied using Epstein Barr virus transformed B-lymphoblastoid cells expressing membrane IgG against tetanus toxin. As previously reported (Watts, C., and H.W. Davidson. 1988. EMBO (Eur. Mol. Biol. Organ.) J.
Davidson, H. W., Watts, C.
openaire   +4 more sources

Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in Human Immunodeficiency Virus Type 1 infection [PDF]

, 2004
Numerous studies now support that human immunodeficiency virus type 1 (HIV-1) evolution is influenced by immune selection pressure, with population studies showing an association between specific HLA alleles and mutations within defined cytotoxic T ...
Allen, T.M., Altfeld, M., Brander, C., Cohen, D.E., Freedberg, K.A., Goulder, P.J.R., John, M., Johnston, M.N., Kalife, E.T., Le Gall, S., Lee, P.K., Lichterfeld, M., Mallal, S.A., Mothe, B.R., O'Sullivan, K.M., Rosenberg, E.S., Sette, A., Strick, D.A., Walker, B.D., Yu, X.G.   +19 more
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Molecular definition of a major cytotoxic T-lymphocyte epitope in the glycoprotein of lymphocytic choriomeningitis virus [PDF]

Journal of Virology, 1988
Analyses with segmental reassortants of lymphocytic choriomeningitis virus (LCMV) RNA have shown that cytotoxic T lymphocytes (CTL) are induced by and recognize proteins encoded by the viral short segment, which specifies two virus structural proteins, glycoprotein (GP) and nucleoprotein (NP).
Michael B. A. Oldstone, Hanna Lewicki, J. R. Gebhard, Antoinette Tishon, J. L. Whitton   +4 more
openaire   +3 more sources

Genome-wide Characterization of a Viral Cytotoxic T Lymphocyte Epitope Repertoire [PDF]

Journal of Biological Chemistry, 2003
A genome-wide search using major histocompatibility complex (MHC) class I binding and proteosome cleavage site algorithms identified 101 influenza A PR8 virus-derived peptides as potential epitopes for CD8+ T cell recognition in the H-2b mouse. Cytokine-based flow cytometry, ELISPOT, and cytotoxic T lymphocyte assays reveal that 16 are recognized by ...
Zhong, Weimin, Reche Gallardo, Pedro Antonio, Lai, Char-Chang, Reinhold, Bruce, Reinherz, Ellis L   +4 more
openaire   +5 more sources

Differential narrow focusing of immunodominant human immunodeficiency virus Gag-specific cytotoxic T-Lymphocyte responses in infected African and Caucasoid adults and children [PDF]

, 2000
Cytotoxic T-lymphocyte (CTL) activity plays a central role in control of viral replication and in determining outcome in cases of human immunodeficiency virus type 1 (HIV-1) infection.
Altfeld, M.A., Annamalai, K., Brander, C., Bunce, M., Burchett, S.A., Cao, H., Coovadia, H.M., Goulder, P.J.R., Govender, U., Hammond, M., Hartman, K.E., He, S., Kalams, S.A., McIntosh, K., Mngqundaniso, N., O'Callaghan, C.A., Ogg, G.S., Pelton, S.I., Rosenberg, E.S., Tang, Y., Walker, B.D.   +20 more
core   +2 more sources

Large-scale validation of methods for cytotoxic T-lymphocyte epitope prediction [PDF]

BMC Bioinformatics, 2007
Reliable predictions of Cytotoxic T lymphocyte (CTL) epitopes are essential for rational vaccine design. Most importantly, they can minimize the experimental effort needed to identify epitopes. NetCTL is a web-based tool designed for predicting human CTL epitopes in any given protein.
Larsen, Mette V, Lundegaard, Claus, Lamberth, Kasper, Buus, Søren, Lund, Ole, Nielsen, Morten   +5 more
openaire   +6 more sources

Analogue peptides for the immunotherapy of human acute myeloid leukemia [PDF]

, 2015
Accepted manuscript. The final publication is available at: http://link.springer.com/article/10.1007%2Fs00262-015-1762-9The use of peptide vaccines, enhanced by adjuvants, has shown some efficacy in clinical trials.
A Driessche Van, A Gros, A Scardino, A Serrano, A Sevko, A Snyder, A Tsuboi, AB Bakker, Aleksandrs Malinovskis, Andrew Mead, AT Cheuk, AW Purcell, B Engels, B Falini, B Maecker, B Maecker, B Uttenthal, BA Guinn, BA Guinn, Barbara-ann Guinn, C Chaise, C Maccalli, CL Slingluff Jr, D Cilloni, D Mason, DA Gross, DE Speiser, DH Chang, DJ Schwartzentruber, E Estey, E Romano, F Ghiringhelli, FS Hodi, G Khan, H Kobayashi, H Ohminami, HJ Kolb, HJ Stauss, I Bellantuono, J Bae, J Bae, J Fourcade, J Greiner, J Greiner, J Kronke, J Pinilla-Ibarz, J Pinilla-Ibarz, JH Sampson, JJ Molldrem, JL Chen, JL Chen, JN Kochenderfer, JS Ko, JW Wells, K Inoue, K Inoue, K Rezvani, K Rezvani, KM Zirlik, L Chan, L Fong, L Gao, LV Ly, M Harndahl, M Kapp, M Subklewe, MA Cheever, MG Warnock, MM Gubin, MR Parkhurst, MS Bijker, N Hardwick, Nicola R. Hardwick, O Christensen, O Hamid, P Brossart, P Bruggen van der, P Keskinen, PG Maslak, PG Maslak, R Cibotti, RA Padua, RF Schlenk, RJ May, S Frankild, S Hofmann, S Narayan, S Ochsenreither, S Pascolo, S Suekane, S Walter, SH Burg van der, SK Singh, SL Topalian, SP Adams, Susanne Hofmann, T Lovgren, U Keilholz, U Sahin, V Bhardwaj, WS Meng, Y Oka, Z Trajanoski   +102 more
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Novel, cross-restricted, conserved, and immunodominant Cytotoxic T Lymphocyte epitopes in slow progressors in HIV Type 1 infection [PDF]

, 1996
HIV-specific cytotoxic T lymphocytes (CTLs) play an important role in the immune response to HIV infection. Long-term nonprogressors (LTNPs) or slow progressors (SPs) in HIV infection may make qualitatively different CTL responses compared to those ...
ANDREW J. McMICHAEL, ANNE EDWARDS, BARBARA MORGAN, Culmann B, Johnson RP, KARL McINTYRE, McMichael AJ, MIKE BUNCE, PAUL GIANGRANDE, PETER KRAUSA, PHILIP J.R. GOULDER, RODNEY E. PHILLIPS, SIOBHAN CROWLEY   +12 more
core   +2 more sources