Results 1 to 10 of about 46,724 (194)

Molecular assessment of the HIV pol gene and use of computational vaccine design targeting Pakistani isolates [PDF]

Scientific Reports
Human immunodeficiency virus (HIV) is considered a major threat to human health. The global prevalence of individuals infected with HIV-1 continues to rise.
Akmal Zubair, Faisal Ahmad, Syeda Maryam Hussain, Zahid Manzoor, Ahmed Al-Emam, Safa Wdidi   +5 more
doaj   +2 more sources

A therapeutic multi-epitope protein vaccine targeting HPV16 E6 E7 elicits potent tumor regression and cytotoxic immune responses [PDF]

Cancer Biology & Medicine
Objective: Cervical cancer caused by persistent high-risk human papillomavirus (hrHPV) infection remains a leading cause of cancer-related mortality in women.
Lanfang Zhu, Jingtao Pu, Yufen Tao, Lei Shi, Shuyuan Liu, Xinwen Zhang, Weipeng Liu, Ming Sun, Yufeng Yao, Li Shi   +9 more
doaj   +2 more sources

Targeting SOX9: designing a novel vaccine against triple-negative breast cancer [PDF]

Scientific Reports
Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype that lacks targeted therapies. This study aimed to design a novel multi-epitope peptide vaccine targeting SOX9, a transcription factor associated with TNBC progression ...
Ghazaleh Hatamian, Amirali Ebrahimpour, Mojgan Nejabat, Farzin Hadizadeh   +3 more
doaj   +2 more sources

Phylogenetic and Immune Epitope Analysis of Hepatitis B Surface Antigen in Chronic Carriers from Tabriz, Northwest of Iran [PDF]

ImmunoAnalysis, 2022
Background: The purpose of this investigation was to specify the genotypes and subtypes of hepatitis B virus (HBV) by phylogenetic analysis and to investigate the mutations in the S gene region in chronic patients with hepatitis B surface antigen (HBsAg)-
Fatemeh Ebrahimi, Mahin Ahangar Oskoee, Hossein Bannazadeh Baghi, Javid Sadeghi, Mohammad Ahangarzadeh Rezaei, Omid Gholizadeh, Nader Mohammadzadeh, Ahmad Dashti, Vahdat Poortahmasebi   +8 more
doaj   +1 more source

Designing a multi-epitope vaccine against Peptostreptococcus anaerobius based on an immunoinformatics approach

Synthetic and Systems Biotechnology, 2023
Peptostreptococcus anaerobius is an anaerobic bacterium, which has been found selectively en-riched in the fecal and mucosal microbiota of colorectal cancer (CRC) patients. Emerging evidence suggest P.
Yudan Mao, Xianzun Xiao, Jie Zhang, Xiangyu Mou, Wenjing Zhao   +4 more
doaj   +1 more source

Design of a Recombinant Multivalent Epitope Vaccine Based on SARS-CoV-2 and Its Variants in Immunoinformatics Approaches

Frontiers in Immunology, 2022
The development of an effective multivalent vaccine against SARS-CoV-2 variants is an important means to improve the global public health situation caused by COVID-19. In this study, we identified the antigen epitopes of the main global epidemic SARS-CoV-
Mingkai Yu, Mingkai Yu, Yuejie Zhu, Yujiao Li, Zhiqiang Chen, Zhiqiang Chen, Zhiwei Li, Jing Wang, Zheng Li, Fengbo Zhang, Fengbo Zhang, Jianbing Ding, Jianbing Ding   +12 more
doaj   +1 more source

Sporozoite glycoprotein antigen (SGA) of Cryptosporidium parvum is a promising vaccine target for prevention of cryptosporidiosis In silico analysis of C. parvum SGA protein

Informatics in Medicine Unlocked, 2023
Cryptosporidiosis is a zoonotic parasitic infection causing diarrhea in humans and farm animals. The present study was done to computationally analyze the Cryptosporidium parvum sporozoite glycoprotein antigen (SGA) regarding immunogenic epitopes, as a ...
Bahareh Kordi, Amir Fotovati, Hamidreza Majidiani, Hadi Fazel, Esfandiar Azizi, Morteza Shams, Amir Abaszadeh   +6 more
doaj   +1 more source

Design of a multi-epitope vaccine candidate against Brucella melitensis

Scientific Reports, 2022
Brucella is a typical facultative intracellular bacterium that can cause zoonotic infections. For Brucella, it is difficult to eliminate with current medical treatment.
Min Li, Yuejie Zhu, Ce Niu, Xinru Xie, Gulishati Haimiti, Wenhong Guo, Mingkai Yu, Zhiqiang Chen, Jianbing Ding, Fengbo Zhang   +9 more
doaj   +1 more source

Identification of CTL Epitopes on Efflux Pumps of the ATP-Binding Cassette and the Major Facilitator Superfamily of Mycobacterium tuberculosis

Journal of Immunology Research, 2021
Tuberculosis is the world’s most deadly infectious disease, with 10 million people falling ill and 1.5 million people dying from the disease every year. With the increasing number of drug-resistant Mycobacterium tuberculosis (MTB) strains and prevalence ...
Yan Lin, Yu Dong, Yanfeng Gao, Ranran Shi, Yubing Li, Xiuman Zhou, Wenwen Liu, Guodong Li, Yuanming Qi, Yahong Wu   +9 more
doaj   +1 more source

Exploring the structural basis to develop efficient multi-epitope vaccines displaying interaction with HLA and TAP and TLR3 molecules to prevent NIPAH infection, a global threat to human health

PLoS ONE, 2023
Nipah virus (NiV) is an emerging zoonotic virus that caused several serious outbreaks in the south asian region with high mortality rates ranging from 40 to 90% since 2001. NiV infection causes lethal encephalitis and respiratory disease with the symptom
Sukrit Srivastava, Sonia Verma, Mohit Kamthania, Ajay Kumar Saxena, Kailash C. Pandey, Veena Pande, Michael Kolbe   +6 more
doaj   +2 more sources