Results 11 to 20 of about 395,501 (352)

Screening helper T lymphocyte epitopes based on IFN-γ/IL-10 ratio for developing a novel multi-epitope vaccine candidate using Wolbachia surface protein as an adjuvant against visceral leishmaniasis. [PDF]

Parasit Vectors
Background Visceral leishmaniasis (VL) is the most lethal form of leishmaniasis. In terms of anti-leishmanial vaccines, favorable immune responses are Th1 responses that primarily produce interferon gamma (IFN-γ) and activate macrophages for ...
Zhang J, Lv T, Tan S, Yu L, Chi Y, Chen J, Fan X, Lu X.   +7 more
europepmc   +2 more sources

<i>In silico</i> screening and identification of CTL and HTL epitopes in the secreted virulence factors of Mycobacterium tuberculosis. [PDF]

BioTechnologia (Pozn)
Background Mycobacterium tuberculosis (MTb) is a highly infectious pathogen and a global health threat due to its resilient cell wall and immune evasion strategies.
Bragais EKB, Heralde FM, Fernandez KCJ, Caoili SEC, Herrera-Ong LR.   +4 more
europepmc   +2 more sources

Epitope Prediction Assays Combined with Validation Assays Strongly Narrows down Putative Cytotoxic T Lymphocyte Epitopes [PDF]

Vaccines, 2015
Tumor vaccine design requires prediction and validation of immunogenic MHC class I epitopes expressed by target cells as well as MHC class II epitopes expressed by antigen-presenting cells essential for the induction of optimal immune responses. Epitope prediction methods are based on different algorithms and are instrumental for a first screening of ...
Ip, Peng, Nijman, Hans, Daemen, Toos
openaire   +5 more sources

A comprehensive strategy for the development of a multi-epitope vaccine targeting <i>Treponema pallidum</i>, utilizing heat shock proteins, encompassing the entire process from vaccine design to <i>in vitro</i> evaluation of immunogenicity. [PDF]

Front Microbiol
BackgroundTreponema pallidum, the causative spirochete of syphilis, is primarily transmitted through sexual contact and has emerged as a significant global health concern.
Jiang J, Xu L, Wang X, Wang M, Cao Y, Li R, Zheng K, Wu X.   +7 more
europepmc   +2 more sources

Identification of CD8 T-Lymphocyte Epitopes in OmpB ofRickettsia conorii [PDF]

Infection and Immunity, 2003
ABSTRACTThe 1.2-kb DNA fragment of theRickettsia conoriiouter membrane protein B gene (OmpB451-846) was subcloned using site-specific PCR primers and expressed as six smaller fragments: OmpB458-652, OmpB595-744, OmpB595-654, OmpB645-692, OmpB689-744, and OmpB739-848.
Zhen Li, Gustavo Valbuena, David H. Walker, Hui Min Feng, Xue Jie Yu, Juan P. Olano, C. Marcela Díaz-Montero   +6 more
openaire   +4 more sources

Pan-vaccinomics strategy for developing a universal multi-epitope vaccine against endocarditis-related pathogens. [PDF]

Front Immunol
IntroductionEndocarditis is a life-threatening infection of the heart valves, frequently caused by pathogenic bacteria. The growth of multidrug-resistant bacteria necessitates the development of innovative therapeutic techniques, such as vaccines ...
Chao P, Zhang X, Zhang L, Ma W, Wang D, Yang A, Chen X.   +6 more
europepmc   +2 more sources

Escherichia coli shares T- and B-lymphocyte epitopes with Schistosoma mansoni

The Journal of Infection in Developing Countries, 2009
In this study, we tested the cross-reaction between crude Escherichia coli antigen (ECA) and 3 crude Schistosoma mansoni antigens.The schistosomal antigens used were cercarial antigen preparation (CAP), soluble worm antigen preparation (SWAP), and soluble egg antigen (SEA).
Amany Sayed Maghraby, Hanaa M. Gaber, Mahmoud M. Bahgat   +2 more
openaire   +6 more sources

Identification of Cytotoxic T Lymphocyte Epitopes on Swine Viruses: Multi-Epitope Design for Universal T Cell Vaccine [PDF]

PLoS ONE, 2013
Classical swine fever (CSF), foot-and-mouth disease (FMD) and porcine reproductive and respiratory syndrome (PRRS) are the primary diseases affecting the pig industry globally. Vaccine induced CD8(+) T cell-mediated immune response might be long-lived and cross-serotype and thus deserve further attention.
Wen-Bin Chung, Chieh-Hua Lin, Hsin-Hung Lin, Yu-Chieh Liao   +3 more
openaire   +4 more sources

Design of multi-epitope-based therapeutic vaccine candidates from HBc and HBx proteins of hepatitis B virus using reverse vaccinology and immunoinformatics approaches. [PDF]

PLoS One
The major problem in cases of chronic hepatitis B (CHB) is the failure of the patient's immune response to eliminate the covalently closed circular DNA (cccDNA) minichromosome of hepatitis B virus (HBV).
Naully PG, Tan MI, Nugrahapraja H, Artarini AA, Aditama R, Giri-Rachman EA.   +5 more
europepmc   +2 more sources

Phylogenetic and Immune Epitope Analysis of Hepatitis B Surface Antigen in Chronic Carriers from Tabriz, Northwest of Iran [PDF]

ImmunoAnalysis, 2022
Background: The purpose of this investigation was to specify the genotypes and subtypes of hepatitis B virus (HBV) by phylogenetic analysis and to investigate the mutations in the S gene region in chronic patients with hepatitis B surface antigen (HBsAg)-
Fatemeh Ebrahimi, Mahin Ahangar Oskoee, Hossein Bannazadeh Baghi, Javid Sadeghi, Mohammad Ahangarzadeh Rezaei, Omid Gholizadeh, Nader Mohammadzadeh, Ahmad Dashti, Vahdat Poortahmasebi   +8 more
doaj   +1 more source