Results 11 to 20 of about 46,724 (194)
Vaccines, 2015 Tumor vaccine design requires prediction and validation of immunogenic MHC class I epitopes expressed by target cells as well as MHC class II epitopes expressed by antigen-presenting cells essential for the induction of optimal immune responses.
Peng Peng Ip +2 more
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Frontiers in Microbiology, 2023 Porcine epidemic diarrhea virus (PEDV), a continuously evolving pathogen, causes severe diarrhea in piglets with high mortality rates. However, current vaccines cannot provide complete protection against PEDV, so vaccine development is still necessary ...
Wei Hou +6 more
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Learning from HIV-1 to predict the immunogenicity of T cell epitopes in SARS-CoV-2
iScience, 2021 Summary: We describe a physics-based learning model for predicting the immunogenicity of cytotoxic T lymphocyte (CTL) epitopes derived from diverse pathogens including SARS-CoV-2. The model was trained and optimized on the relative immunodominance of CTL
Ang Gao +11 more
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PLoS ONE, 2023 Monkeypox virus (MPXV) outbreaks have been reported in various countries worldwide; however, there is no specific vaccine against MPXV. In this study, therefore, we employed computational approaches to design a multi-epitope vaccine against MPXV ...
Samira Sanami +8 more
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Epitope-Based Vaccine Target Screening against Highly Pathogenic MERS-CoV: An In Silico Approach Applied to Emerging Infectious Diseases. [PDF]
PLoS ONE, 2015 Middle East respiratory syndrome coronavirus (MERS-CoV) with pandemic potential is a major worldwide threat to public health. However, vaccine development for this pathogen lags behind as immunity associated with protection is currently largely unknown ...
Jiandong Shi +10 more
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Immunogenicity of two FMDV nonameric peptides encapsulated in liposomes in mice and the protective efficacy in guinea pigs. [PDF]
PLoS ONE, 2013 It has been predicted that nonameric peptides I (VP1(26-34), RRQHTDVSF), II (VP1(157-165), RTLPTSFNY) and III (VP1(45-53), KEQVNVLDL) from the VP1 capsid protein of the foot-and-mouth disease virus (FMDV) are T cell epitopes. To investigate whether these
Feng-Shan Gao +5 more
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Frontiers in Immunology, 2023 IntroductionThe current monkeypox (MPX) outbreak, caused by the monkeypox virus (MPXV), has turned into a global concern, with over 59,000 infection cases and 23 deaths worldwide.ObjectivesHerein, we aimed to exploit robust immunoinformatics approach ...
Muhammad Waqas +10 more
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In silico design of a promiscuous chimeric multi-epitope vaccine against Mycobacterium tuberculosis
Computational and Structural Biotechnology Journal, 2023 Tuberculosis (TB) is a global health threat, killing approximately 1.5 million people each year. The eradication of Mycobacterium tuberculosis, the main causative agent of TB, is increasingly challenging due to the emergence of extensive drug-resistant ...
Binda T. Andongma +7 more
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Designing a conjugate vaccine targeting Klebsiella pneumoniae ST258 and ST11
HeliyonKlebsiella pneumoniae (K. pneumoniae) is a common bacterium that can cause iatrogenic infection. Recently, the rise of antibiotic resistance among K. pneumoniae strains is one key factor associated with antibiotic treatment failure.
Min Li +7 more
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Designing a Multi-Epitope Vaccine against Toxoplasma gondii: An Immunoinformatics Approach
Vaccines, 2022 Infection with the intracellular apicomplexan parasite Toxoplasma gondii causes serious clinical outcomes in both human and veterinary settings worldwide. Although approximately one-third of the world’s population is infected with T. gondii, an effective
Mutiat Hammed-Akanmu +7 more
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