Results 21 to 30 of about 395,501 (352)

Design of a Recombinant Multivalent Epitope Vaccine Based on SARS-CoV-2 and Its Variants in Immunoinformatics Approaches

Frontiers in Immunology, 2022
The development of an effective multivalent vaccine against SARS-CoV-2 variants is an important means to improve the global public health situation caused by COVID-19. In this study, we identified the antigen epitopes of the main global epidemic SARS-CoV-
Mingkai Yu, Mingkai Yu, Yuejie Zhu, Yujiao Li, Zhiqiang Chen, Zhiqiang Chen, Zhiwei Li, Jing Wang, Zheng Li, Fengbo Zhang, Fengbo Zhang, Jianbing Ding, Jianbing Ding   +12 more
doaj   +1 more source

Design of a multi-epitope vaccine candidate against Brucella melitensis

Scientific Reports, 2022
Brucella is a typical facultative intracellular bacterium that can cause zoonotic infections. For Brucella, it is difficult to eliminate with current medical treatment.
Min Li, Yuejie Zhu, Ce Niu, Xinru Xie, Gulishati Haimiti, Wenhong Guo, Mingkai Yu, Zhiqiang Chen, Jianbing Ding, Fengbo Zhang   +9 more
doaj   +1 more source

Identification of CTL Epitopes on Efflux Pumps of the ATP-Binding Cassette and the Major Facilitator Superfamily of Mycobacterium tuberculosis

Journal of Immunology Research, 2021
Tuberculosis is the world’s most deadly infectious disease, with 10 million people falling ill and 1.5 million people dying from the disease every year. With the increasing number of drug-resistant Mycobacterium tuberculosis (MTB) strains and prevalence ...
Yan Lin, Yu Dong, Yanfeng Gao, Ranran Shi, Yubing Li, Xiuman Zhou, Wenwen Liu, Guodong Li, Yuanming Qi, Yahong Wu   +9 more
doaj   +1 more source

TITAN: T Cell Receptor Specificity Prediction with Bimodal Attention Networks [PDF]

Bioinformatics 37 (2021): i237-i244, 2021
Motivation: The activity of the adaptive immune system is governed by T-cells and their specific T-cell receptors (TCR), which selectively recognize foreign antigens. Recent advances in experimental techniques have enabled sequencing of TCRs and their antigenic targets (epitopes), allowing to research the missing link between TCR sequence and epitope ...
arxiv   +1 more source

Exploring the structural basis to develop efficient multi-epitope vaccines displaying interaction with HLA and TAP and TLR3 molecules to prevent NIPAH infection, a global threat to human health.

PLoS ONE, 2023
Nipah virus (NiV) is an emerging zoonotic virus that caused several serious outbreaks in the south asian region with high mortality rates ranging from 40 to 90% since 2001. NiV infection causes lethal encephalitis and respiratory disease with the symptom
Sukrit Srivastava, Sonia Verma, Mohit Kamthania, Ajay Kumar Saxena, Kailash C Pandey, Veena Pande, Michael Kolbe   +6 more
doaj   +2 more sources

In silico design and immunoinformatics analysis of a universal multi-epitope vaccine against monkeypox virus

PLoS ONE, 2023
Monkeypox virus (MPXV) outbreaks have been reported in various countries worldwide; however, there is no specific vaccine against MPXV. In this study, therefore, we employed computational approaches to design a multi-epitope vaccine against MPXV ...
Samira Sanami, Shahin Nazarian, Sajjad Ahmad, Elham Raeisi, Muhammad Tahir ul Qamar, Shahram Tahmasebian, Hamidreza Pazoki-Toroudi, Maryam Fazeli, Mahdi Ghatreh Samani   +8 more
doaj   +2 more sources

BeeTLe: A Framework for Linear B-Cell Epitope Prediction and Classification [PDF]

, 2023
The process of identifying and characterizing B-cell epitopes, which are the portions of antigens recognized by antibodies, is important for our understanding of the immune system, and for many applications including vaccine development, therapeutics, and diagnostics.
arxiv   +1 more source

Designing a multi-epitope vaccine to control porcine epidemic diarrhea virus infection using immunoinformatics approaches

Frontiers in Microbiology, 2023
Porcine epidemic diarrhea virus (PEDV), a continuously evolving pathogen, causes severe diarrhea in piglets with high mortality rates. However, current vaccines cannot provide complete protection against PEDV, so vaccine development is still necessary ...
Wei Hou, Heqiong Wu, Sibei Wang, Wenting Wang, Bin Wang, Bin Wang, Haidong Wang   +6 more
doaj   +1 more source

The Membrane Protein of Severe Acute Respiratory Syndrome Coronavirus Acts as a Dominant Immunogen Revealed by a Clustering Region of Novel Functionally and Structurally Defined Cytotoxic T-Lymphocyte Epitopes

Journal of Infectious Diseases, 2010
Background. Severe acute respiratory syndrome coronavirus (SARS-CoV), which emerged with highly contagious and life-threatening characteristics in 2002, remains a potential risk for future outbreaks.
Jun Liu, Yeping Sun, J. Qi, F. Chu, Hao Wu, F. Gao, Taisheng Li, Jinghua Yan, G. Gao   +8 more
semanticscholar   +1 more source

Conserved HIV-1 epitopes continuously elicit subdominant cytotoxic T-lymphocyte responses.

Journal of Infectious Diseases, 2009
BACKGROUND The epitope specificities and antiviral activities of class I HLA-restricted CD8(+) T cells, especially those induced during human immunodeficiency virus type 1 (HIV-1) primary infection, are important considerations in designing HIV-1 ...
Yi Liu, J. McNevin, M. Rolland, Hong-ring Zhao, Wenjie Deng, J. Maenza, Claire E. Stevens, Ann C. Collier, M. McElrath, James I. Mullins   +9 more
semanticscholar   +1 more source