Results 31 to 40 of about 395,501 (352)
Epitope-Based Vaccine Target Screening against Highly Pathogenic MERS-CoV: An In Silico Approach Applied to Emerging Infectious Diseases. [PDF]
PLoS ONE, 2015 Middle East respiratory syndrome coronavirus (MERS-CoV) with pandemic potential is a major worldwide threat to public health. However, vaccine development for this pathogen lags behind as immunity associated with protection is currently largely unknown ...
Jiandong Shi +10 more
doaj +1 more source
European Journal of Immunology, 1999 We here demonstrate that placing two distinct influenza virus nucleoprotein epitopes at the N terminus of a cytosolic protein selectively blocks their presentation to specific cytotoxic T lymphocytes. The block is a cytosolic phenomenon, which can be overcome by distancing the epitope from the protein N terminus by two or more amino acids.
Gileadi, U +3 more
openaire +4 more sources
European Journal of Medicinal Chemistry, 2020 Identification of epitopes recognized by tumour B cells could provide insights into the molecular mechanisms of B cell tumorigenesis through aberrant B cell receptor (BCR) signalling. Here, we analysed the structure of eleven peptides binders of BCRs expressed in Chronic Lymphocytic Leukemia (CLL) patients in order to identify the chemical features ...
Antonio Lupia +11 more
openaire +3 more sources
Synthetic and Systems Biotechnology, 2023 Peptostreptococcus anaerobius is an anaerobic bacterium, which has been found selectively en-riched in the fecal and mucosal microbiota of colorectal cancer (CRC) patients. Emerging evidence suggest P.
Yudan Mao +4 more
doaj
Journal of General Virology, 2007 The influenza A virus nucleoprotein (NP) and matrix protein are major targets for human virus-specific cytotoxic T-lymphocyte (CTL) responses. Most of the CTL epitopes that have been identified so far are conserved.
E. Berkhoff +4 more
semanticscholar +1 more source
Identification of cytotoxic T lymphocyte epitopes of human herpesvirus 8
Immunology, 2002 SummaryThe human herpesvirus 8 (HHV‐8) is a human γ2‐herpesvirus that is implicated in the development of Kaposi's sarcoma (KS), primary effusion lymphoma and Castelman's disease. Since the responses of cytotoxic T lymphocytes (CTL) play a key role in the control of herpesvirus infection, it is important to identify and to characterize the CTL target ...
MICHELETTI, Fabiola +9 more
openaire +4 more sources
Immunogenicity of two FMDV nonameric peptides encapsulated in liposomes in mice and the protective efficacy in guinea pigs. [PDF]
PLoS ONE, 2013 It has been predicted that nonameric peptides I (VP1(26-34), RRQHTDVSF), II (VP1(157-165), RTLPTSFNY) and III (VP1(45-53), KEQVNVLDL) from the VP1 capsid protein of the foot-and-mouth disease virus (FMDV) are T cell epitopes. To investigate whether these
Feng-Shan Gao +5 more
doaj +1 more source
Prediction of CTL epitopes using QM, SVM and ANN techniques [PDF]
, 2004 Cytotoxic T lymphocyte (CTL) epitopes are potential candidates for subunit vaccine design for various diseases. Most of the existing T cell epitope prediction methods are indirect methods that predict MHC class I binders instead of CTL epitopes.
Bhasin, Manoj, Raghava, G. P. S.
core +1 more source
Frontiers in Immunology, 2023 IntroductionThe current monkeypox (MPX) outbreak, caused by the monkeypox virus (MPXV), has turned into a global concern, with over 59,000 infection cases and 23 deaths worldwide.ObjectivesHerein, we aimed to exploit robust immunoinformatics approach ...
Muhammad Waqas +10 more
doaj +1 more source
Stability-mediated epistasis constrains the evolution of an influenza protein. [PDF]
, 2013 John Maynard Smith compared protein evolution to the game where one word is converted into another a single letter at a time, with the constraint that all intermediates are words: WORD→WORE→GORE→GONE→GENE. In this analogy, epistasis constrains evolution,
Bloom, Jesse D +2 more
core +1 more source