Results 241 to 250 of about 1,305,585 (286)

Ergosterol Attenuates Palmitate-Induced Tenocyte Apoptosis Through the Suppression of ER Stress and Myocyte-Derived IL-15/METRNL-Mediated Crosstalk. [PDF]

Mycobiology
Pyo MK, Ko JH, Abd El-Aty AM, Jeong JH, Lee KT, Jung TW.   +5 more
europepmc   +1 more source

ER stress marker manuscript

Scientific manuscript summarising the methods and results of the completed research on ER stress marker changes in Parkinson's disease brains. The manuscript will be submitted in a scientific journal or published via other means to be eventually decided by the responsible partners.
openaire   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

F41, a Novel Fungal Indole-Diterpenoid, Overcomes Gemcitabine Resistance in Pancreatic Cancer by Inducing ER Stress. [PDF]

Int J Mol Sci
Gao Z, Liu L, Xu Y, Zhao C, Zhao X, Zhao T, Che Y, Zhao W.   +7 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

ER stress in D1-MSNs mediates cocaine-induced behavioral plasticity <i>via</i> the ATF4-SPTLC1 axis. [PDF]

Front Pharmacol
Zhao Y, Li S, Jiang L, Zhao Y, Kuang W, Wei Q, Zhou Y, Han S, Wang L, Li H, Dai Y, Yang X, Xu S, Qin F, Chen R, Chen Y, Liu C, Bu Q, Chen B, Liu B, Qin M, Zhao Y, Cen X.   +22 more
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Reductive stress induces unresolved ER stress and proteotoxic cardiomyopathy. [PDF]

Redox Biol
Sunny S, Radhakrishnan RK, Devarajan A, Masjoan Juncos JX, Bansal M, Ouyang X, Zhang J, Xie M, Litovsky SH, Trinity JD, Might M, Pogwizd SM, Kontaridis MI, Rajasekaran NS.   +13 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Author Response: Concerns Regarding Control Group Design and Statistical Rigor in the Study on ER Stress-Induced Neuroinflammation via LCN2. [PDF]

Invest Ophthalmol Vis Sci
Huang W, Lu R.
europepmc   +1 more source