Structure of cellular ESCRT-III spirals and their relationship to HIV budding [PDF]
eLife, 2014 The ESCRT machinery along with the AAA+ ATPase Vps4 drive membrane scission for trafficking into multivesicular bodies in the endocytic pathway and for the topologically related processes of viral budding and cytokinesis, but how they accomplish this ...
Anil G Cashikar +5 more
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ESCRT-III mediated cell division in Sulfolobus acidocaldarius –A reconstitution perspective [PDF]
Frontiers in Microbiology, 2014 In the framework of Synthetic Biology, it has become an intriguing question what would be the minimal representation of cell division machinery. Thus, it seems appropriate to compare how cell division is realized in different microorganisms.
Tobias eHärtel, Petra eSchwille
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A relay race of ESCRT-III paralogs drives cell division in a hyperthermophilic archaeon [PDF]
mBioCell division is a fundamental process ensuring the perpetuation of all cellular life forms. Archaea of the order Sulfolobales divide using a simpler version of the eukaryotic endosomal sorting complexes required for transport (ESCRT) machinery, composed
Junfeng Liu +6 more
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ESCRT-III is recruited by human herpesvirus 6A nuclear egress complex to promote nuclear egress of the nucleocapsid [PDF]
Journal of VirologyHerpesviruses replicate their genomes and package them into capsids within the host cell nucleus. These capsids must then translocate from the nucleus to the cytoplasm through a process designated nuclear egress. The virus-encoded nuclear egress complex (
Aila Gulijiahani +5 more
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An Inducible ESCRT-III Inhibition Tool to Control HIV-1 Budding [PDF]
Viruses, 2023 HIV-1 budding as well as many other cellular processes require the Endosomal Sorting Complex Required for Transport (ESCRT) machinery. Understanding the architecture of the native ESCRT-III complex at HIV-1 budding sites is limited due to spatial ...
Haiyan Wang +8 more
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ESCRT-III: a versatile membrane remodeling machinery and its implications in cellular processes and diseases [PDF]
Animal Cells and SystemsThe endosomal sorting complexes required for transport (ESCRT) machinery is an evolutionarily conserved cytosolic protein complex that plays a crucial role in membrane remodeling and scission events across eukaryotes.
Jisoo Park +4 more
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Accessory ESCRT‐III proteins are conserved and selective regulators of Rab11a‐exosome formation [PDF]
Journal of Extracellular Vesicles, 2023 Exosomes are secreted nanovesicles with potent signalling activity that are initially formed as intraluminal vesicles (ILVs) in late Rab7‐positive multivesicular endosomes, and also in recycling Rab11a‐positive endosomes, particularly under some forms of
Pauline P. Marie +10 more
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The Asgard archaeal ESCRT-III system forms helical filaments and remodels eukaryotic-like membranes [PDF]
The EMBO JournalThe ESCRT machinery mediates membrane remodeling in numerous processes in cells including cell division and nuclear membrane reformation. The identification of ESCRT homologs in Asgard archaea, currently considered the closest prokaryotic relative of ...
Nataly Melnikov +10 more
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mBio, 2018 Intracellular pathogens have varied strategies to breach the endolysosomal barrier so that they can deliver effectors to the host cytosol, access nutrients, replicate in the cytoplasm, and avoid degradation in the lysosome.
Ekansh Mittal +7 more
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Nuclear and degradative functions of the ESCRT-III pathway: implications for neurodegenerative disease [PDF]
NucleusThe ESCRT machinery plays a pivotal role in membrane-remodeling events across multiple cellular processes including nuclear envelope repair and reformation, nuclear pore complex surveillance, endolysosomal trafficking, and neuronal pruning.
Olivia Keeley, Alyssa N. Coyne
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