Results 91 to 100 of about 14,499 (192)
Advanced Science, EarlyView.This study presents a DNA hydrogel‐mediated delivery system, in which ginsenoside (GS) molecules are incorporated into small extracellular vesicles (sEV) secreted by mesenchymal stem cells (MSCs) and the formed complexes are then anchored in DNA hydrogels via aptamer‐CD63 affinity as “GS/sEV@DNAgels”, to improve diabetic wound repair.
Jianming Xing +14 more
wiley +1 more source
Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase
eLife, 2017 Many important cellular membrane fission reactions are driven by ESCRT pathways, which culminate in disassembly of ESCRT-III polymers by the AAA ATPase Vps4. We report a 4.3 Å resolution cryo-EM structure of the active Vps4 hexamer with its cofactor Vta1,
Nicole Monroe +4 more
doaj +1 more source
Cryo-EM Structure of Dodecameric Vps4p and Its 2:1 Complex with Vta1p [PDF]
, 2008 The type I AAA (ATPase associated with a variety of cellular activities) ATPase Vps4 and its co-factor Vta1p/LIP5 function in membrane remodeling events that accompany cytokinesis, multivesicular body biogenesis, and retrovirus budding, apparently by ...
Gonciarz, Malgorzata D. +4 more
core +2 more sources
Advanced Intelligent Discovery, EarlyView.Exosomes are emerging as powerful biomarkers for disease diagnosis and monitoring. This review highlights the integration of surface‐enhanced Raman spectroscopy with artificial intelligence to enhance molecular fingerprinting of exosomes. Machine learning and deep learning techniques improve spectral interpretation, enabling accurate classification of ...
Munevver Akdeniz +2 more
wiley +1 more source
Stability of ESCRT III Snf7 Polymer Influenced by: Bro1 and Vps2/Vps24 [PDF]
, 2016 The endosomal sorting complexes required for transport (ESCRT) are protein complexes that remodel cellular membranes. The ESCRT III membrane machinery has been implicated in regulating membrane bound receptor proteins through the multi-vesicular body ...
Coody, Troy K, III
core +2 more sources
Advanced Intelligent Discovery, EarlyView.This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah +3 more
wiley +1 more source
ESCRT-III and HIV-1 release [PDF]
Retrovirology, 2013 Enveloped viruses such as HIV-1 recruit ESCRT complexes (endosomal sorting complexes required for transport) to escape from cells. Although five complexes constitute the endosomal ESCRT machinery, only ESCRT-III and VPS4 are recruited to all ESCRT-catalyzed processes thereby executing membrane fission.
openaire +1 more source
Nucleus, 2020 Cellular aging occurs as a cell loses its ability to maintain homeostasis. Aging cells eliminate damaged cellular compartments and other senescence factors via self-renewal.
Bailey A. Koch +3 more
doaj +1 more source
CHARACTERIZATION OF THE UBIQUITIN LIGASE, UBE4B, IN ENDOCYTIC TRAFFICKING [PDF]
, 2017 Endocytosis is a process by which cells internalize membrane proteins to remove them from the plasma membrane, allowing cells to regulate the cell surface expression of transmembrane proteins.
Sirisaengtaksin, Natalie +1 more
core +1 more source
Nature's lessons in design: nanomachines to scaffold, remodel and shape membrane compartments. [PDF]
, 2015 Compartmentalisation of cellular processes is fundamental to regulation of metabolism in Eukaryotic organisms and is primarily provided by membrane-bound organelles.
Achalkumar +198 more
core +2 more sources