Results 111 to 120 of about 14,499 (192)

Lem2p (LEM2) and Cmp7p (CHMP7) function in ESCRT-dependent nuclear envelope remodeling in fission yeast [PDF]

, 2016
ESCRT‐III proteins have been implicated in sealing the nuclear envelope in mammals, both during nuclear assembly and following mechanical disruption. This sealing process requires the ESCRT‐II/ESCRT‐ III hybrid protein CHMP7 and the AAA ATPase VPS4.
Bjorkman, P. J., Chen, O. S., Frost, A., Gu, M., Ladinsky, M. S., Sundquist, W. I.   +5 more
core  

Electron Tomography of HIV-1 Infection in Gut-Associated Lymphoid Tissue [PDF]

, 2014
Critical aspects of HIV-1 infection occur in mucosal tissues, particularly in the gut, which contains large numbers of HIV-1 target cells that are depleted early in infection.
Bjorkman, Pamela J., Deruaz, Maud, Kieffer, Collin, Kwon, Douglas S., Ladinsky, Mark S., Olson, Gregory, Tager, Andrew M., Vrbanac, Vladimir   +7 more
core   +6 more sources

Defender or accomplice? Dual roles of plant vesicle trafficking in restricting and enabling geminiviral systemic infection

New Phytologist, EarlyView.
Summary The vesicle trafficking system enables multidirectional cargo fluxes between endomembrane compartments. However, vesicle trafficking plays dual roles during pathogen infections. In plants, it mediates autophagic immune responses but can also be hijacked by pathogens to facilitate successful infections.
Pepe Cana‐Quijada, Pablo Morales‐Martínez, Tábata Rosas‐Díaz, Jessica Pérez‐Sancho, Tamara Jiménez‐Góngora, José Antonio Navarro, Rosa Lozano‐Durán, Araceli G. Castillo, Vicente Pallás, Eduardo R. Bejarano   +9 more
wiley   +1 more source

Tobamoviruses CP Proteins Hijack Light‐Induced Protein (NbLIP1) to Promote Viral Replication by Facilitating VRO Formation

Plant Biotechnology Journal, EarlyView.
ABSTRACT Tobamoviruses establish viral replication organelles (VROs) on the host endoplasmic reticulum (ER) for their replication, a process demanding substantial different types of lipids. However, how viruses efficiently transfer these lipids from other compartments like chloroplasts remains incompletely understood.
Haoyu Chen, Mingjie Wu, Xiao Guo, Hongmei Xu, Chenwei Feng, Duxuan Liu, Jing Hua, Yanhong Hua, Zhen He, Peter Moffett, Kun Zhang   +10 more
wiley   +1 more source

ESCRT Machinery Mediates Cytokinetic Abscission in the Unicellular Red Alga Cyanidioschyzon merolae

Frontiers in Cell and Developmental Biology, 2020
In many eukaryotes, cytokinesis proceeds in two successive steps: first, ingression of the cleavage furrow and second, abscission of the intercellular bridge.
Fumi Yagisawa, Fumi Yagisawa, Takayuki Fujiwara, Takayuki Fujiwara, Takayuki Fujiwara, Tokiaki Takemura, Tokiaki Takemura, Yuki Kobayashi, Nobuko Sumiya, Shin-ya Miyagishima, Shin-ya Miyagishima, Shin-ya Miyagishima, Soichi Nakamura, Yuuta Imoto, Osami Misumi, Osami Misumi, Kan Tanaka, Haruko Kuroiwa, Tsuneyoshi Kuroiwa   +18 more
doaj   +1 more source

Wrapping up the bad news: HIV assembly and release. [PDF]

, 2013
The late Nobel Laureate Sir Peter Medawar once memorably described viruses as 'bad news wrapped in protein'. Virus assembly in HIV is a remarkably well coordinated process in which the virus achieves extracellular budding using primarily intracellular ...
Lever, Andrew Ml, Meng, Bo
core   +3 more sources

ESCRT-I Protein Tsg101 Plays a Role in the Post-macropinocytic Trafficking and Infection of Endothelial Cells by Kaposi's Sarcoma-Associated Herpesvirus.

PLoS Pathogens, 2016
Kaposi's sarcoma-associated herpesvirus (KSHV) binding to the endothelial cell surface heparan sulfate is followed by sequential interactions with α3β1, αVβ3 and αVβ5 integrins and Ephrin A2 receptor tyrosine kinase (EphA2R).
Binod Kumar, Dipanjan Dutta, Jawed Iqbal, Mairaj Ahmed Ansari, Arunava Roy, Leela Chikoti, Gina Pisano, Mohanan Valiya Veettil, Bala Chandran   +8 more
doaj   +1 more source

A non-canonical ESCRT pathway, including His domain phosphotyrosine phosphatase (HD-PTP), is used for down-regulation of virally ubiquitinated MHC Class I [PDF]

, 2015
The Kaposi’s sarcoma-associated herpes virus (KSHV) K3 viral gene product effectively down-regulates cell surface MHC Class I. K3 is an E3 ubiquitin ligase that promotes K63-linked polyubiquitination of MHC Class I, providing the signal for clathrin ...
Boname, JM, Bowers, K, Bright, NA, Evans, JL, Lehner, PJ, Luzio, JP, Parkinson, MDJ, Piper, SC   +7 more
core  

Extracellular Vesicles: Biology, Intercellular Communication and Therapeutic Potential in Diabetes

Advanced Therapeutics, Volume 9, Issue 2, February 2026.
Exosome packaging in diabetes mellitus is depicted. Induced expression levels of RBP4, WNT related proteins, TGFB1, BMPs, VEGFs, STAT3, Calpain2 and altered expression levels of microRNAs in the exosomes are responsible for the inflammatory actions, defective central metabolism, myofibroblasts proliferation, dysregulated cell migration, cell ...
Swayam Prakash Srivastava, Lydia Herrmann, Eden Ozkan, Abhiram Kunamneni, Vinamra Swaroop, Geetika Nehra, Rohit Srivastava, Pratima Tripathi, Ken Inoki, Julie E. Goodwin   +9 more
wiley   +1 more source

Parallel Genome‐Wide CRISPR Screens Reveal SORL1 and ZFYVE19 as Sequential Host Determinants of Salmonella Infection

Advanced Science, Volume 13, Issue 8, 9 February 2026.
To distinguish how Salmonella invades cells vs how it survives long‐term, a parallel CRISPR screening platform is developed. This approach reveals the host proteins that the bacterium exploits at different stages of infection. The study identifies SORL1 as a novel host factor for invasion and demonstrates that blocking it with an antibody effectively ...
Sehee Yun, Seoyeon Kim, Seonggyu Kim, Minsoo Noh, Dae‐Kyum Kim, Eun‐Jin Lee, Hunsang Lee   +6 more
wiley   +1 more source