Results 121 to 130 of about 14,499 (192)

ESCRT machinery mediates selective microautophagy of endoplasmic reticulum in yeast

, 2019
ER-phagy, the selective autophagy of endoplasmic reticulum (ER), safeguards organelle homeostasis by eliminating misfolded proteins and regulating ER size. ER-phagy can occur by macroautophagic and microautophagic mechanisms.
Charlotta Funaya, Dimitrios Papagiannidis, Giulia Ruffini, Jasmin A Schäfer, Julia P Schessner, Katharina Schaeff, Michael Knop, Oliver Pajonk, Peter W Bircham, Sebastian Schuck, Takuma Tsuji, Toyoshi Fujimoto, Vergères G   +12 more
core   +2 more sources

CHMP1B is a target of USP8/UBPY regulated by ubiquitin during endocytosis.

PLoS Genetics, 2018
Integration and down-regulation of cell growth and differentiation signals rely on plasma membrane receptor endocytosis and sorting towards either recycling vesicles or degradative lysosomes via multivesicular bodies (MVB). In this process, the endosomal
Xènia Crespo-Yàñez, Carmen Aguilar-Gurrieri, Anne-Claire Jacomin, Agnès Journet, Magda Mortier, Emmanuel Taillebourg, Emmanuelle Soleilhac, Winfried Weissenhorn, Marie-Odile Fauvarque   +8 more
doaj   +1 more source

Disrupting Lipid Raft Microdomains to Block Polyploid Giant Cancer Cell Budding and Enhance Radiotherapy Response

Advanced Science, Volume 13, Issue 9, 13 February 2026.
Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng, Haoran Sun, Jin Cheng, Ruyi Zhao, Jianzhu Xie, Yanwei Song, Yucui Zhao, Chenwei Lin, Binjie Hu, Yanping Gong, Jun Lin, Sijia He, Yuntao Luo, Minghui Zhao, Yiwei Wang, Ming Jiao, Yuqin Yang, Jikun Li, Shujie Xia, Chuanyuan Li, Qian Huang   +20 more
wiley   +1 more source

Computational Model of Membrane Fission Catalyzed by ESCRT-III

PLoS Computational Biology, 2009
ESCRT-III proteins catalyze membrane fission during multi vesicular body biogenesis, budding of some enveloped viruses and cell division. We suggest and analyze a novel mechanism of membrane fission by the mammalian ESCRT-III subunits CHMP2 and CHMP3.
Favrikant, G, Lata, S, Riches, JD, Briggs, JAG, Weissenhorn, W, Kozlov, MM   +5 more
openaire   +6 more sources

ESCRT-III subunits Snf7-1 and Snf7-2 differentially regulate transmembrane cargos in hESC-derived human neurons

Molecular Brain, 2011
Backgrounds Endosomal sorting complex required for transport (ESCRT) is involved in several fundamental cellular processes and human diseases. Many mammalian ESCRT proteins have multiple isoforms but their precise functions remain largely unknown ...
Lee Jin-A, Liu Lei, Javier Robyn, Kreitzer Anatol C, Delaloy Celine, Gao Fen-Biao   +5 more
doaj   +1 more source

Tissue‐Specific Extracellular Vesicles Enriched From Circulation: Exploring the Liquid Biopsy Perspective

Journal of Extracellular Biology, Volume 5, Issue 2, February 2026.
ABSTRACT Extracellular vesicles (EVs) released from tissues can be found in human biofluids. EVs reflect the phenotypic state of their cell of origin, carrying informative molecular biomarkers within and between tissues, and represent a promising target for liquid biopsy.
Biancamaria Pierri, Erez Eitan, Kenneth W. Witwer, Diane B. Re, Andrea A. Baccarelli, Haotian Wu   +5 more
wiley   +1 more source

Research Progress of Exosome‐Derived microRNA in Alcohol Use Disorders: A Critical Review

Addiction Biology, Volume 31, Issue 2, February 2026.
Exosome‐derived microRNAs represent stable and mechanistically active mediators of alcohol‐induced multi‐organ injury. This review summarizes how chronic alcohol exposure reshapes exosomal miRNA cargo across the liver, immune system, and brain, highlighting key miRNAs with diagnostic value and therapeutic potential.
Bo Zhang, Ting ting Xie, Qiang Ma, Ya ping Jiang, Yu mei Wang   +4 more
wiley   +1 more source

Cryo-EM structures of the ATP-bound Vps4E233Q hexamer and its complex with Vta1 at near-atomic resolution

Nature Communications, 2017
The ESCRT-III and Vps4 complexes mediate a variety of membrane remodelling events. Here the authors describe the structure of the Vps4 hexamer complexed to its cofactor Vta1, and show that Vta1 bridges adjacent Vps4 subunits to promote formation of the ...
Shan Sun, Lin Li, Fan Yang, Xiaojing Wang, Fenghui Fan, Mengyi Yang, Chunlai Chen, Xueming Li, Hong-Wei Wang, Sen-Fang Sui   +9 more
doaj   +1 more source

Electrostatic Interactions between Elongated Monomers Drive Filamentation of Drosophila Shrub, a Metazoan ESCRT-III Protein

Cell Reports, 2016
The endosomal sorting complex required for transport (ESCRT) is a conserved protein complex that facilitates budding and fission of membranes. It executes a key step in many cellular events, including cytokinesis and multi-vesicular body formation.
Brian J. McMillan, Christine Tibbe, Hyesung Jeon, Andrew A. Drabek, Thomas Klein, Stephen C. Blacklow   +5 more
doaj   +1 more source

Frontotemporal Dementia Linked to Chromosome 3 in Saccharomyces cerevisiae [PDF]

, 2013
Frontotemporal dementia (FTD) represents a crippling new neurodegenerative disease for scientific investigation. Marked by characteristic frontal and temporal lobar cortical atrophy, FTD results in the progressive deterioration of social and behavioral ...
Sulkko, Niles
core   +2 more sources