Results 11 to 20 of about 14,499 (192)
Design principles of the ESCRT-III Vps24-Vps2 module [PDF]
eLife, 2021 ESCRT-III polymerization is required for all endosomal sorting complex required for transport (ESCRT)-dependent events in the cell. However, the relative contributions of the eight ESCRT-III subunits differ between each process.
Sudeep Banjade +3 more
doaj +3 more sources
Methylation of ESCRT-III components regulates the timing of cytokinetic abscission [PDF]
Nature CommunicationsAbscission is the final stage of cytokinesis, which cleaves the intercellular bridge (ICB) connecting two daughter cells. Abscission requires tight control of the recruitment and polymerization of the Endosomal Protein Complex Required for Transport-III (
Aurélie Richard +15 more
doaj +2 more sources
Modelling membrane reshaping by staged polymerization of ESCRT-III filaments. [PDF]
PLoS Computational Biology, 2022 ESCRT-III filaments are composite cytoskeletal polymers that can constrict and cut cell membranes from the inside of the membrane neck. Membrane-bound ESCRT-III filaments undergo a series of dramatic composition and geometry changes in the presence of an
Xiuyun Jiang +7 more
doaj +2 more sources
Electrostatic lateral interactions drive ESCRT-III heteropolymer assembly
eLife, 2019 Self-assembly of ESCRT-III complex is a critical step in all ESCRT-dependent events. ESCRT-III hetero-polymers adopt variable architectures, but the mechanisms of inter-subunit recognition in these hetero-polymers to create flexible architectures remain ...
Sudeep Banjade +3 more
doaj +3 more sources
VPS4B orchestrates response to nuclear envelope stress by regulating ESCRT-III dynamics in glioblastoma [PDF]
NucleusThe Nuclear envelope (NE) is frequently challenged by mechanical stimuli involving cells passing through a tight space and such stress is known as “NE stress.” Various factors that cooperate to repair the NE have been identified, including endosomal ...
Zuqian Wu +4 more
doaj +2 more sources
Vps60 initiates alternative ESCRT-III filaments. [PDF]
J Cell Biol, 2023 Endosomal sorting complex required for transport-III (ESCRT-III) participates in essential cellular functions, from cell division to endosome maturation. The remarkable increase of its subunit diversity through evolution may have enabled the acquisition of novel functions. Here, we characterize a novel ESCRT-III copolymer initiated by Vps60.
Pfitzner AK +7 more
europepmc +4 more sources
ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins [PDF]
eLife, 2015 The endosomal sorting complexes required for transport (ESCRT) machinery mediates the physical separation between daughter cells during cytokinetic abscission.
Anna Caballe +9 more
doaj +4 more sources
Developmental Cell, 2002 The endosomal sorting complex required for transport (ESCRT) system is essential for multivesicular body biogenesis, in which cargo sorting is coupled to the invagination and scission of intralumenal vesicles. The ESCRTs are also needed for budding of enveloped viruses including human immunodeficiency virus 1, and for membrane abscission in cytokinesis.
Babst, Markus +4 more
openaire +4 more sources
A complex network of interactions between mitotic kinases, phosphatases and ESCRT proteins regulates septation and membrane trafficking in S. pombe [PDF]
, 2014 Cytokinesis and cell separation are critical events in the cell cycle. We show that Endosomal Sorting Complex Required for Transport (ESCRT) genes are required for cell separation in Schizosaccharomyces pombe.
Bhutta, Musab S. +3 more
core +26 more sources
Physical mechanisms of ESCRT-III-driven cell division. [PDF]
Proc Natl Acad Sci U S A, 2022 Significance Cell division is an essential requirement for life. Division requires mechanical forces, often exerted by protein assemblies from the cell interior, that split a single cell into two. Using coarse-grained computer simulations and live cell imaging we define a distinct cell division mechanism—based on the forces ...
Harker-Kirschneck L +11 more
europepmc +5 more sources