Results 21 to 30 of about 14,499 (192)

The endosomal sorting complex required for transport repairs the membrane to delay cell death

Frontiers in Oncology, 2022
The endosomal sorting complex required for transport (ESCRT) machinery plays a key role in the repair of damaged plasma membranes with puncta form and removes pores from the plasma membrane in regulated cell death, apoptosis, necroptosis, pyroptosis ...
Ye Yang, Min Wang, Ying-Ying Zhang, Shu-Zhi Zhao, Shu-Zhi Zhao, Song Gu   +5 more
doaj   +1 more source

Insights into the function of ESCRT and its role in enveloped virus infection

Frontiers in Microbiology, 2023
The endosomal sorting complex required for transport (ESCRT) is an essential molecular machinery in eukaryotic cells that facilitates the invagination of endosomal membranes, leading to the formation of multivesicular bodies (MVBs).
Chunxuan Wang, Yu Chen, Shunlin Hu, Xiufan Liu, Xiufan Liu, Xiufan Liu   +5 more
doaj   +1 more source

Bro1 binds the Vps20 subunit of ESCRT-III and promotes ESCRT-III regulation by Doa4. [PDF]

Traffic, 2022
AbstractThe budding of intralumenal vesicles (ILVs) at endosomes requires membrane scission by the ESCRT‐III complex. This step is negatively regulated in yeast by Doa4, the ubiquitin hydrolase that deubiquitinates transmembrane proteins sorted as cargoes into ILVs. Doa4 acts non‐enzymatically to inhibit ESCRT‐III membrane scission activity by directly
Buysse D, West M, Leih M, Odorizzi G.
europepmc   +3 more sources

Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission

eLife, 2022
The 12 related human ESCRT-III proteins form filaments that constrict membranes and mediate fission, including during cytokinetic abscission. The C-terminal tails of polymerized ESCRT-III subunits also bind proteins that contain Microtubule-Interacting ...
Dawn M Wenzel, Douglas R Mackay, Jack J Skalicky, Elliott L Paine, Matthew S Miller, Katharine S Ullman, Wesley I Sundquist   +6 more
doaj   +1 more source

Annexin A7 mediates lysosome repair independently of ESCRT-III. [PDF]

Front Cell Dev Biol, 2023
Lysosomes are crucial organelles essential for various cellular processes, and any damage to them can severely compromise cell viability. This study uncovers a previously unrecognized function of the calcium- and phospholipid-binding protein Annexin A7 in lysosome repair, which operates independently of the Endosomal Sorting Complex Required for ...
Ebstrup ML, Sønder SL, Fogde DL, Heitmann ASB, Dietrich TN, Dias C, Jäättelä M, Maeda K, Nylandsted J.   +8 more
europepmc   +7 more sources

ESCRT-III–dependent membrane repair blocks ferroptosis [PDF]

Biochemical and Biophysical Research Communications, 2020
Ferroptosis is a form of regulated cell death that is triggered by iron accumulation and lipid peroxidation. Although plasma membrane injuries represent an important event in cell death, the impact of membrane repair mechanisms on ferroptosis remains unidentified.
Enyong Dai, Lingjun Meng, Rui Kang, Xiaofeng Wang, Daolin Tang   +4 more
openaire   +2 more sources

ESCRT-III controls nuclear envelope reformation [PDF]

Nature, 2015
During telophase, the nuclear envelope (NE) reforms around daughter nuclei to ensure proper segregation of nuclear and cytoplasmic contents. NE reformation requires the coating of chromatin by membrane derived from the endoplasmic reticulum, and a subsequent annular fusion step to ensure that the formed envelope is sealed.
Olmos, Yolanda, Hodgson, Lorna, Mantell, Judith, Verkade, Paul, Carlton, Jeremy G   +4 more
openaire   +5 more sources

Structural basis for ESCRT-III protein autoinhibition [PDF]

Nature Structural & Molecular Biology, 2009
Endosomal sorting complexes required for transport-III (ESCRT-III) subunits cycle between two states: soluble monomers and higher-order assemblies that bind and remodel membranes during endosomal vesicle formation, midbody abscission and enveloped virus budding.
Bajorek, Monika, Schubert, Heidi L., McCullough, John, Langelier, Charles, Eckert, Debra M., Stubblefield, William-May B., Uter, Nathan T., Myszka, David G., Hill, Christopher P., Sundquist, Wesley I.   +9 more
openaire   +2 more sources

The ESCRT Machinery: Remodeling, Repairing, and Sealing Membranes

Membranes, 2022
The ESCRT machinery is an evolutionarily conserved membrane remodeling complex that is used by the cell to perform reverse membrane scission in essential processes like protein degradation, cell division, and release of enveloped retroviruses. ESCRT-III,
Yolanda Olmos
doaj   +1 more source

AKTIP interacts with ESCRT I and is needed for the recruitment of ESCRT III subunits to the midbody.

PLoS Genetics, 2021
To complete mitosis, the bridge that links the two daughter cells needs to be cleaved. This step is carried out by the endosomal sorting complex required for transport (ESCRT) machinery. AKTIP, a protein discovered to be associated with telomeres and the
Chiara Merigliano, Romina Burla, Mattia La Torre, Simona Del Giudice, Hsiangling Teo, Chong Wai Liew, Alexandre Chojnowski, Wah Ing Goh, Yolanda Olmos, Klizia Maccaroni, Maria Giubettini, Irene Chiolo, Jeremy G Carlton, Domenico Raimondo, Fiammetta Vernì, Colin L Stewart, Daniela Rhodes, Graham D Wright, Brian E Burke, Isabella Saggio   +19 more
doaj   +1 more source