Results 41 to 50 of about 14,499 (192)

Hydraulic fracturing in cells and tissues: fracking meets cell biology [PDF]

, 2017
The animal body is fundamentally made of water. A small fraction of this water is freely flowing in blood and lymph, but most of it is trapped in hydrogels such as the extracellular matrix (ECM), the cytoskeleton, and chromatin.
Arroyo Balaguer, Marino, Trepat Guixer, Xavier   +1 more
core   +4 more sources

CHMP2B mutants linked to frontotemporal dementia impair maturation of dendritic spines.: CHMP2B and dendritic spines [PDF]

, 2010
International audienceThe highly conserved ESCRT-III complex is responsible for deformation and cleavage of membranes during endosomal trafficking and other cellular activities.
Bajorek, Banker, Boyer, Carlton, Fabrikant, Ferrer, Fiala, Filimonenko, Hamill, Hanson, Henkemeyer, Hurley, Lata, Lee, Lee, Lipton, Matsuzaki, Morfini, Muziol, Noguchi, Passafaro, Rodriguez, Rodriguez, Rusten, Saksena, Sevrioukov, Skibinski, Slagsvold, Stuchell-Brereton, Sweeney, Urwin, Vaccari, von Schwedler, Wei, Wishart, Wollert, Wollert, Yasumatsu, Zamborlini   +38 more
core   +3 more sources

Membranumbau durch ESCRT-III-Proteine

BIOspektrum, 2022
AbstractTo maintain their function, cellular membranes require membrane remodelling, mediated by protein machineries like the ESCRT-III that deforms and breaks membranes in different cellular functions. Its mechanism of function is still unknown. However, recent findings on the ESCRT-IIIs’ structural and dynamic features, such as their ability to alter
openaire   +1 more source

Vps68 cooperates with ESCRT-III in intraluminal vesicle formation [PDF]

Journal of Cell Science, 2022
AbstractThe endosomal sorting complex required for transport (ESCRT)-III mediates budding and abscission of intraluminal vesicles (ILVs) into multivesicular endosomes. To further define the role of the ESCRT-III associated protein Mos10/Vps60 in ILV formation, we screened for new interaction partners by SILAC/MS.
Sören Alsleben, Ralf Kölling
openaire   +2 more sources

Human ESCRT-III polymers assemble on positively curved membranes and induce helical membrane tube formation

Nature Communications, 2020
ESCRT-III complexes assemble in vivo inside membrane structures with a negative Gaussian curvature, but how membrane shape influences ESCRT-III polymerization remains unclear.
Aurélie Bertin, Nicola de Franceschi, Eugenio de la Mora, Sourav Maity, Maryam Alqabandi, Nolwen Miguet, Aurélie di Cicco, Wouter H. Roos, Stéphanie Mangenot, Winfried Weissenhorn, Patricia Bassereau   +10 more
doaj   +1 more source

Cellular ESCRT components are recruited to regulate the endocytic trafficking and RNA replication compartment assembly during classical swine fever virus infection.

PLoS Pathogens, 2022
As the important molecular machinery for membrane protein sorting in eukaryotic cells, the endosomal sorting and transport complexes (ESCRT-0/I/II/III and VPS4) usually participate in various replication stages of enveloped viruses, such as endocytosis ...
Chun-Chun Liu, Ya-Yun Liu, Jiang-Fei Zhou, Xi Chen, Huan Chen, Jia-Huan Hu, Jing Chen, Jin Zhang, Rui-Cong Sun, Jian-Chao Wei, Yun Young Go, Eiji Morita, Bin Zhou   +12 more
doaj   +1 more source

ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting. [PDF]

, 2012
The sorting of signaling receptors to lysosomes is an essential regulatory process in mammalian cells. During degradation, receptors are modified with ubiquitin and sorted by endosomal sorting complex required for transport (ESCRT)-0, -I, -II, and -III ...
Chen, Buxin, Dores, Michael R, Lin, Huilan, Meerloo, Timo, Montagne, William A, Paing, May M, Soh, Unice JK, Trejo, JoAnn   +7 more
core   +3 more sources

Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation [PDF]

Nature Cell Biology, 2020
The ESCRT-III membrane fission machinery maintains the integrity of the nuclear envelope. Although primary nuclei resealing takes minutes, micronuclear envelope ruptures seem to be irreversible. Instead, micronuclear ruptures result in catastrophic membrane collapse and are associated with chromosome fragmentation and chromothripsis, complex chromosome
Marina Vietri, Sebastian W. Schultz, Aurélie Bellanger, Carl M. Jones, Louise I. Petersen, Camilla Raiborg, Ellen Skarpen, Christeen Ramane J. Pedurupillay, Ingrid Kjos, Eline Kip, Romy Timmer, Ashish Jain, Philippe Collas, Roland L. Knorr, Sushma N. Grellscheid, Halim Kusumaatmaja, Andreas Brech, Francesca Micci, Harald Stenmark, Coen Campsteijn   +19 more
openaire   +5 more sources

Functional Reconstitution of ESCRT-III Assembly and Disassembly [PDF]

Cell, 2009
Receptor downregulation in the MVB pathway is mediated by the ESCRT complexes. ESCRT-III is composed of four protein subunits that are monomeric in the cytosol and oligomerize into a protein lattice only upon membrane binding. Recent studies have shown that the ESCRT-III protein Snf7 can form a filament by undergoing homo-oligomerization.
Saksena, Suraj, Wahlman, Judit, Teis, David, Johnson, Arthur E., Emr, Scott D.   +4 more
openaire   +6 more sources

Component Interaction of ESCRT Complexes Is Essential for Endocytosis-Dependent Growth, Reproduction, DON Production and Full Virulence in Fusarium graminearum

Frontiers in Microbiology, 2019
Multivesicular bodies (MVBs) are critical intermediates in the trafficking of ubiquitinated endocytosed surface proteins to the lysosome/vacuole for destruction.
Qiurong Xie, Qiurong Xie, Ahai Chen, Ahai Chen, Yunzhi Zhang, Yunzhi Zhang, Mingyue Yuan, Mingyue Yuan, Wei Xie, Wei Xie, Chengkang Zhang, Chengkang Zhang, Wenhui Zheng, Wenhui Zheng, Zonghua Wang, Zonghua Wang, Guangpu Li, Guangpu Li, Jie Zhou, Jie Zhou   +19 more
doaj   +1 more source