Results 61 to 70 of about 14,499 (192)
Frontiers in Cellular and Infection Microbiology, 2021 The endosomal sorting complex required for transport (ESCRT) is formed by ESCRT-0, ESCRT-I, ESCRT-II, ESCRT-III complexes, and accessory proteins. It conducts vesicular trafficking in eukaryotes through the formation of vesicles and membrane fission and ...
Ausencio Galindo +8 more
doaj +1 more source
ESCRT-0 is not required for ectopic Notch activation and tumor suppression in Drosophila.
PLoS ONE, 2014 Multivesicular endosome (MVE) sorting depends on proteins of the Endosomal Sorting Complex Required for Transport (ESCRT) family. These are organized in four complexes (ESCRT-0, -I, -II, -III) that act in a sequential fashion to deliver ubiquitylated ...
Emiliana Tognon +4 more
doaj +1 more source
Genomic Inference of the Metabolism and Evolution of the Archaeal Phylum Aigarchaeota [PDF]
, 2018 Microbes of the phylum Aigarchaeota are widely distributed in geothermal environments, but their physiological and ecological roles are poorly understood.
Castelle, Cindy J. +14 more
core +3 more sources
ESCRT-III Dysfunction Causes Autophagosome Accumulation and Neurodegeneration [PDF]
Current Biology, 2007 Defects in the endosomal-lysosomal pathway have been implicated in a number of neurodegenerative disorders. A key step in the endocytic regulation of transmembrane proteins occurs in a subset of late-endosomal compartments known as multivesicular bodies (MVBs), whose formation is controlled by endosomal sorting complex required for transport (ESCRT ...
Lee, Jin-A. +4 more
openaire +3 more sources
ESCRT function in cytokinesis : location, dynamics and regulation by mitotic kinases [PDF]
, 2014 Mammalian cytokinesis proceeds by constriction of an actomyosin ring and furrow ingression, resulting in the formation of the midbody bridge connecting two daughter cells. At the centre of the midbody resides the Flemming body, a dense proteinaceous ring
Bhutta, Musab S. +2 more
core +1 more source
Helical Structures of ESCRT-III Are Disassembled by VPS4 [PDF]
Science, 2008 During intracellular membrane trafficking and remodeling, protein complexes known as the ESCRTs (endosomal sorting complexes required for transport) interact with membranes and are required for budding processes directed away from the cytosol, including the budding of intralumenal vesicles to form multivesicular bodies; for the budding of some ...
Suman, Lata +6 more
openaire +3 more sources
ESCRT-III and ER–PM contacts maintain lipid homeostasis [PDF]
Molecular Biology of the Cell, 2020 Saturating transposon mutagenesis screen identified the ESCRTs as synthetic genetic interactors in ER–PM contact mutant. The synthetic phenotype is caused by defects in lipid synthesis. Other ESCRT complexes, and VPS4 do not have a synthetic growth phenotype, indicating that only ESCRT-III proteins function in this lipid regulation pathway.
Jorgensen, Jeff R. +5 more
openaire +2 more sources
Changes in ESCRT-III filament geometry drive membrane remodelling and fission in silico
BMC Biology, 2019 Background ESCRT-III is a membrane remodelling filament with the unique ability to cut membranes from the inside of the membrane neck. It is essential for the final stage of cell division, the formation of vesicles, the release of viruses, and membrane ...
Lena Harker-Kirschneck +2 more
doaj +1 more source
LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells [PDF]
, 2016 Endosomal sorting complexes required for transport III (ESCRT-III) proteins have been implicated in sealing the nuclear envelope in mammals, spindle pole body dynamics in fission yeast, and surveillance of defective nuclear pore complexes in budding ...
Bjorkman, Pamela J. +10 more
core +1 more source
Membrane Constriction and Thinning by Sequential ESCRT-III Polymerization [PDF]
Biophysical Journal, 2019 AbstractThe Endosomal Sorting Complexes Required for Transport (ESCRTs) mediate diverse membrane remodeling events. These activities typically require ESCRT-III proteins to stabilize negatively-curved membranes, although recent work has indicated that certain ESCRT-IIIs also participate in positive-curvature membrane shaping reactions.
Nguyen, Henry C. +8 more
openaire +6 more sources