Results 71 to 80 of about 3,091,776 (257)

Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis

Advanced Science, EarlyView.
This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Yingdong Liu, Shanyao Liu, Haixin Liang, Jiani Yang, Yanhe Li, Jiqing Yin, Xueguang Zhang, Yan Zhang, Dandan Bai, Zihui Yan, Zhuoao Zhang, Yanping Jia, Kuisheng Liu, Yifan Sheng, Jiani Xiang, Chenxiang Xi, Baoxing Dong, Xinyi Lei, Jiayu Chen, Hong Wang, Yi Guo, Yanping Zhang, Shaorong Gao, Wenqiang Liu   +23 more
wiley   +1 more source

Rethinking pre-training: cognitive load implications for learners with varying prior knowledge

Frontiers in Psychology
This study examines how prior knowledge and pre-training relate to cognitive load during problem-solving. Grounded in cognitive load theory, it investigates whether pre-training facilitates learning by reducing cognitive load or imposes redundant ...
Anna Gorbunova, Anastasiia Kapuza, Ouhao Chen, Jamie Costley   +3 more
doaj   +1 more source

PEMBELAJARAN BERBANTUAN MULTIMEDIA BERDASARKAN COGNITIVE LOAD THEORY PADA PELAJARAN MATEMATIKA SD [PDF]

, 2016
Multimedia is media that combine two or more elements are composed of text, graphics, images, photographs, audio, video, and animation are integrated.
Rissa Prima Kurniawati, Kurniawati, Rissa Prima   +1 more
core   +1 more source

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

Advanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang, Ziting Zhou, Nannan Xue, Jiasi Deng, Yuanyuan Zhou, Xinying Lv, Yuxuan Wang, Yi Zhang, Haotian Pan, Geyan Xu, Yinkun Tao, Mengran Li, Xin Cui, Hongyue Ma, Qian Wang, Zhigang Lu   +15 more
wiley   +1 more source

Multimedia Assisted Learning Based on Cognitive Load Theory to Enhance Capabilities Solving Linear Program in Student X TKR 1 SMK 1 Doko

Jurnal Pendidikan Sains, 2014
Pembelajaran Berbantuan Multimedia Berdasarkan Teori Beban Kognitif untuk Meningkatkan Kemampuan Menyelesaikan Masalah Program Linear Siswa X TKR 1 SMKN 1 Doko Abstract: Based on cognitive load theory, learning effective when administered instrinsic ...
Fifi Damayanti
doaj   +1 more source

Hilfen beim Experimentieren - Auswirkungen unterschiedlicher Arten der Unterstützung auf den extraneous Cognitive Load

, 2019
Schmidt S, Stiller C, Wilde M. Hilfen beim Experimentieren - Auswirkungen unterschiedlicher Arten der Unterstützung auf den extraneous Cognitive Load. Erkenntnisweg Biologiedidaktik.
Wilde, Matthias ; https://orcid.org/, Stiller, Cornelia ; https://orcid.org/, Schmidt, Sofie   +2 more
core  

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

DUET‐seq: An Open‐Source Droplet Platform for High‐Fidelity Joint Chromatin and Transcriptome Profiling Reveals Temporal Regulatory Decoupling in Single Cells

Advanced Science, EarlyView.
DUET‐seq is an open‐source droplet platform that jointly profiles chromatin accessibility and gene expression from the same nucleus. Dissolvable dual‐linker hydrogel beads and a one‐step intra‐droplet RT‐PCR co‐index both modalities in under 12 h at roughly $0.04 per cell.
Dong Cheng, Zijun Meng, Lan Wei, Pingjing Yang, Fanfan Zhang, Zhiyi Luo, Ting Lai, Chunli Li, Mengyao Zhao, Mengqin Xu, Jiaqi Wang, Linjun Li, Huarong Chen, Jin Li, Ailong Huang, Youquan Bu, Liuyang Zhao   +16 more
wiley   +1 more source

Understanding System-induced Cognitive Load with Eye Tracking [PDF]

, 2019
Cognitive load is one important contributor to system usability, and minimizing unnecessary cognitive load can help users better process system information.
Schuetzler, Ryan, Clarke, Martina, Windle, John, Fruhling, Ann, Pachunka, Emily   +4 more
core  

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source