Results 241 to 250 of about 1,408,273 (290)

Silencing OTUB1 induces pyroptosis to inhibit the growth of liver cancer HepG2 cells via the NLRP3/caspase/GSDM signaling pathway. [PDF]

J Gastrointest Oncol
Chu WQ, Xu RL, Liu MN, Hu C, Geng XY, Liu J, Lv C, Li Y, Wang J, Wang XH.   +9 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

OCT4-driven PER1 activation promotes odontogenic differentiation in senescent SCAP spheres. [PDF]

Int J Oral Sci
Li C, Zhang Z, Yang Z, Liu T, He X, Li B, Wang W.   +6 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Protective effects of Zingiber officinale Roscoe in obstetric antiphospholipid syndrome based on systems pharmacology and molecular docking. [PDF]

Medicine (Baltimore)
Du B, Wang H, Wang Q, He N, Wang K, Li H.   +5 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Topical Application of Probiotic-Derived EGF From <i>Pediococcus pentosaceus</i> Improves UVB-Induced Photoaging in Hairless Mice. [PDF]

Ann Dermatol
Roh YJ, Lee YH, Yuh SY, Song HW, Kwon DY, An BC, Ryu Y, Chung MJ, Park KY.   +8 more
europepmc   +1 more source

Exercise Exerts Antidepressant Effects via Endoplasmic Reticulum Stress Modulation: Molecular Mechanisms and Research Progress. [PDF]

Biology (Basel)
Zhou XY, Liu YW, Zhong CH, Xu R, Guan K, Li HN, Huang JT, Xue K, Wang Y, Chen XH.   +9 more
europepmc   +1 more source

Endothelial glycocalyx perturbation in obstructive sleep apnea is associated with repetitive hypoxemia and immunothrombotic endothelial dysfunction. [PDF]

J Transl Med
Müller MB, Kammerer T, Khan H, Schmid A, Hirschberger S, Hübner M, Barth TK, Mitsigiorgi R, Stihl C, Holzer M, Jira D, Patscheider M, Weiss BG, Reichel CA, Uhl B.   +14 more
europepmc   +1 more source