Results 241 to 250 of about 2,205,533 (300)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Effect of sodium lactate on the gel quality of cold-stored <i>Litopenaeus vannamei</i>: Perspective of 4D-DIA proteomics. [PDF]

Food Chem X
Yin Y, Ye H, Cai J, Yin C, Guo T, Xiao N, Wang Z, Wei S, Liu S.   +8 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Fimepinostat Promotes Apoptosis and Decreases Cytokine Secretion in <i>NF2</i>-Related Human Schwannoma Cells. [PDF]

Int J Mol Sci
Nagel A, Hass EW, Hayes H, Huelbes L, Oliveira S, Hardin HM, Marasigan M, Nisenbaum E, Misztal C, Telischi FF, Ivan ME, Liu XZ, Bracho OR, Dinh CT, Fernandez-Valle C.   +14 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Bisphenol F Drives Endoplasmic Reticulum Stress-Mediated Macrophage Polarization, Leading to Inflammation and Fibrosis in Mouse Kidneys. [PDF]

Toxics
Miao C, Fu Y, Zhang B, Yu W, Song M, Li Y, Cao Z.   +6 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Structural diversity of lipid A modulates neutrophil proteome and secretome responses. [PDF]

J Proteomics
Pittaluga Villarreal JR, Kim D, Yoon SH, Bhushan V, Issara-Amphorn J, Pederson J, Manes NP, Nita-Lazar A.   +7 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Genome-Wide Identification of WRKY Group II Genes and the Role of <i>HbWRKY11</i> in <i>Hordeum brevisubulatum</i> Under Saline-Alkali Stress. [PDF]

Plants (Basel)
Chen S, Yin Y, Qi G, Li Y, Jakada BH, Sun D, Liu X, Lan X.   +7 more
europepmc   +1 more source